Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 62 for “"Drug sensitivity"”.
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An ensemble based approach for drug sensitivity prediction
Drug sensitivity prediction based on genomic characterization remains a significant challenge in the area of systems medicine. Multiple approaches have been proposed for mapping genomic characterization to drug sensitivity and among them ensemble based learning techniques such as random forests …
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Deciphering The Role of miR-506 in Ovarian Cancer Drug Sensitivity
… of miR-506 was associated with EOC patients’ sensitivity to platinum treatment, the overall aim of this thesis was to better characterize the role of this miRNA in regulating response to chemotherapy. Among the miR-506 predicted targets, I identified several genes involved in DNA damage repair …
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Ubiquitination of proteins involved in metabolism and immunomodulatory drug sensitivity in lymphocytes
… is required for the efficacy of immunomodulatory drugs (IMiDs) in multiple myeloma (MM), which primarily enable the recognition of neo-substrates by CRBN to elicit their anti-cancer effects. We sought to investigate a role for Fbxo7 in MM cells. We show that Fbxo7 promotes CRBN ubiquitination and …
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Chronic cadmium exposure alters ERα dependency and drug sensitivity of breast cancer cells
… the effect of chronic cadmium exposure on sensitivity to chemotherapeutic drugs was investigated. Our findings suggest that chronic cadmium exposure contributes to breast cancer progression by increasing the adaptability of cells to ERα loss and highlight a potentially new role for chronic …
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Genotypes of SNPs of Key Genes Regulate Susceptibility and Drug Sensitivity to Neovascular AMD
… though their efficacy varies across different drugs and individuals, highlighting the importance of precise drug selection in clinical outcomes. Research suggests that factors such as baseline vision, age, disease duration, lesion size, central retina thickness, neovascularization type, and …
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The effect of distinct BRCA1 splice forms on drug sensitivity in breast- and ovarian cancer cell lines
… how different BRCA1 transcripts can affect the drug sensitivity in breast- and ovarian cancer. The aim of this study was to knock out BRCA1 expression in the T47D breast cancer cell line and the CAOV3 ovarian cancer cell line and overexpress longer and shorter transcripts of BRCA1 in the cells. …
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Exploring the effect of genetic calpain disruption on cell migration, invasion, drug sensitivity, and metastasis in triple negative breast cancer
Triple-negative breast cancer is an aggressive subtype of breast cancer that is associated with high rates of metastasis, which remains incurable. Neoadjuvant chemotherapies, like paclitaxel, have been reported to promote spread to secondary sites. Calpains are a family of calcium-activated …
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Development and evaluation of machine learning algorithms for biomedical applications
Gene network inference and drug response prediction are two important problems in computational biomedicine. The former helps scientists better understand the functional elements and regulatory circuits of cells. The latter helps a physician gain full understanding of the effective treatment on …
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Changing Antimalarial Drug Sensitivities in Uganda
… pressure may select for parasites with decreased sensitivity to lumefantrine. To gain insight into current drug sensitivity patterns, <em>ex vivo</em> sensitivities were assessed and genotypes previously associated with altered drug sensitivity were characterized for 58 isolates collected in …
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Elucidation of the pathways underlying the spectrum of cancers affecting different tissues in lynch syndrome
… it aims to identify subtype-specific drugs targeting these pathways. Using somatic data from cBioPortal (https://www.cbioportal.org), samples were triaged as likely LS (LLS) or likely sporadic (LSp), with computational analyses providing molecular insights into the subtypes of …
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Personalized Medicine: Studies of Pharmacogenomics in Yeast and Cancer
… genotype and gene expression are used to predict drug sensitivity and elucidate the underlying mechanisms. The accuracy and robustness of the algorithm are both evaluated statistically and experimentally validated. The second part of the thesis takes on a much more complicated system: cancer. The …
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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
… L-NMMA and L-NAME have been shown to increase drug sensitivity. As such, L-NMMA and L-NAME co-salt formulations with Oxi8007 were prepared to increase drug sensitivity CA4 and CA1 were coupled with aromatic bioreductive triggers to increase drug response in hypoxic areas that are resistant to …
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Using machine learning to understand the link between gene essentiality, gene expression and the chemosensitivity of cancer cells
… learning in precision medicine, particularly in drug response prediction. In this thesis, an in-depth investigation is conducted on carefully curated and integrated breast cancer focused datasets from the GDSC (Genomics of Drug Sensitivity in Cancer) and Achilles (CRISPR derived) project …
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The Role of Nutrient Availability in Therapeutic Response of Leukemia
… but which extracellular nutrients impact drug sensitivity is largely unknown. In this work, we used functional genomics to identify metabolic modifiers of the response to L-asparaginase (ASNase), a therapy that depletes plasma asparagine and targets leukemic cells with insufficient …
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Determining Mechanisms of Response to Polo-Like Kinase 1 Inhibition In Non-Small Cell Lung Cancer
… evaluated two cancer cell line databases with sensitivity data for a broad range of drugs. We identified polo-like kinase 1 (Plk1) as the most promising target for further investigation based on a subset of sensitive cell lines and inhibitors that were in advanced clinical development. To …
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Genome-wide cross-cancer analysis reveals the importance of bimodal microRNA in predicting patient survival and drug response
… (PI3K) pathway, and a survey of over 200 cancer drugs found that cell lines with high miR-105 and miR-767 levels responded best to drugs targeting the same pathway. To mimic high miR-105 and miR-767-expressing tumors, the two miRNA were overexpressed in A549 lung cancer cells. High miRNA …
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Targeting CDK to Prevent and Treat Retinoblastoma and other Cancers
… To uncover what factors predict CDK inhibitor sensitivity, we generated a transcriptional signature, which reports real-time activity of CDK2 (a potent target of most CDK inhibitors). Surprisingly, we found that CDK2 activity does not predict CDK2 inhibitor sensitivity. Instead, drug …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… three metabolic phenotypes showed differential drug sensitivity. One drug, MM315, an apelin receptor antagonist that is known to play a role in angiogenesis and differentiation of neural progenitor cells, significantly prolonged the survival of orthotopically implanted patient-derived xenografts …
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