Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Drug screen"”.
-
Single-Cell Image Analysis Enables High-Throughput Phenotypic Drug Screen and Elucidates Cell-Fate Decision Principles
… to enable a one-pass multi-class phenotypic drug screen. Our combined experimental and computational approach can functionally annotate large compound libraries across diverse drug classes in a single-pass screen with high prediction accuracy confirmed via orthogonal, secondary validation …
-
Single-Cell Image Analysis Enables High-Throughput Phenotypic Drug Screen and Elucidates Cell-Fate Decision Principles
… to enable a one-pass multi-class phenotypic drug screen. Our combined experimental and computational approach can functionally annotate large compound libraries across diverse drug classes in a single-pass screen with high prediction accuracy confirmed via orthogonal, secondary validation …
-
Toward effective and ethical drug abuse prevention policies: The case against indiscriminate drug testing
… of organizational domains, a negative illicit drug screen result has become the final and paramount criterion for admission and/or continuing participation. Such a policy is vigorously promoted to the private sector by government and vendors of testing services as an inexpensive and vital tool …
-
Part I. Approaches Toward the Total Synthesis of Tyloindicine F; Part II. Palladium-Catalyzed C−H Functionalization of β-enaminones
… in the NCI60 human tumor cell line anticancer drug screen. Due to its scarcity from natural sources, a total synthesis of tyloindicine F is desirable. Two attempts at the synthesis of this natural product have been conducted and are discussed. β-enaminones are a group of push-pull olefins …
-
Characterization of perillyl alcohol as a cell migration-inhibiting compound
… Cancer Institute for use in a large-scale drug screen for anti-migration compounds. Using these assays, we measured the cytotoxicity and migration-inhibiting effect of dimethyl sulfuoxide, a drug solvent, in three cancer and one non-cancer cell lines. Next, we investigated plant-derived …
-
Paper spray mass spectrometry (PS-MS) for toxicological drug screens and biomonitoring of chemical warfare agent exposure
… in two major areas: negative ionization and drug screening. Negative ionization has always been an obstacle to electrospray-based ion sources because of its vulnerability to corona discharge, but methods are presented here to both quantify and suppress this electrical phenomenon, thus …
-
Feasibility Of An Exercise Intervention For Homeless Cocaine-Using Men
… regimen. METHODS: Twenty-five homeless men were screened and five who had used cocaine within the past year were enrolled. All participants completed an initial graded exercise “stress” test. Standardized, vigorous-intensity exercise intervention sessions were held 3 times per week for 6 weeks at …
-
Psychological Measures to Predict Serious Prison Violence
… assessments (Beta-III, MMPI-2-RF, TCU Drug Screen II). Using a logistic regression analysis, history of mental illness and the MMPI-2-RF scale of Psychoticism accurately predicted violent inmates from non-violent inmates while controlling for demographic and criminal variables. A …
-
Combinational Therapy to Mitigate α-Dicarbonyl Toxicity
… unknown. Several supplement grade compounds were screened for TRPA-1-Nrf2 induced activity in <em>Caenorhabditis elegans</em>. The drug screen revealed several candidates that decreased methylglyoxal levels using the TRPA-1-Nrf-2 pathway. Regulatory mechanisms that trigger this detoxification …
-
A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO
… signalling network abnormalities in PBMCs from drug-naïve first-onset schizophrenia patients (n=12) relative to healthy controls (n=12) which are subsequently normalized in PBMCs from the same patients (n=10) after a six week course of clinical treatment with the atypical antipsychotic …
-
Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… evade cell death. A better understanding of how drugs that perturb autophagy affect cancer cell signaling is of critical importance toimprove the cancer treatment arsenal.</p> <p>In order to gain insights in the relationship between autophagy and drug treatments, we conducted a high-throughput …
-
Utilizing Biomarkers to Assess Prevalence and Trends of Substance Use During Pregnancy in Canada
… in social services, and found that rates of polydrug use (specifically opioid use) were similar to a negative control group, with approximately half of individuals continuing to use additional opioids during pregnancy. The second study highlights a routine urine drug screen program within the …
-
Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
… of approximately 15 months. New approaches in drug discovery are needed to facilitate treatment strategies for GBM, hence drug repurposing offers the possibility of rediscovering new off target actions for FDA approved drugs. This is particularly pertinent in the absence of new drugs in …
-
In vivo identification of drug therapeutics for nemaline myopathy
… study employs the DiscoveryProbeTM FDA-approved drug library to perform a small molecule high-throughput drug screen as a strategy for developing therapies for Nemaline Myopathy (NM). Nemaline myopathy is a rare congenital neuromuscular disorder characterized by muscle weakness and the …
-
A FRET Investigation into Molecular Mechanisms of Cardiac Troponin Activation in Reconstituted Thin Filaments
… pathways and other muscle types. Rational drug design can develop therapies to treat CM at the protein level. However, a detailed knowledge of how sarcomeric proteins regulate muscle contraction is required. Muscle contraction occurs through a cyclic interaction between actin thin and …
-
Preclinical Evaluation of Immunomodulatory Effects of Aurora Kinase Inhibition In Human Papillomavirus Positive Cancers
… need, our collaborators conducted a large-scale drug screen and identified Aurora Kinase (AK) inhibitors as a unique class of reagents to induce selective apoptosis in HPV+, but not HPV- human tumor cells in vitro and in vivo in HPV+ patient derived xenografts (PDX) mouse models. We hypothesized …
-
Characterization of Notch1 and Pi3K-Pten-Akt/Mtor Pathway Interaction In Head and Neck Squamous Cell Carcinoma
… that remains at approximately 50%. An unbiased drug screen demonstrated that HNSCC cell lines bearing <em>NOTCH1</em> inactivating mutations are sensitive to PI3K and dual PI3K/mTOR inhibitors, leading us to investigate the interaction of these pathways in HNSCC. The NOTCH pathway plays key …
-
A Pharmacological Strategy Against African Sleeping Sickness
… leading to death. Currently there are 5 approved drugs used to treat it, each with toxic side effects and effective at specific disease stages. A more effective and less toxic drug candidate is highly sought after. The essential enzyme, dUTPase, is an excellent drug target in the parasite while …
-
Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… and (ii) designing an unbiased phenotypic drug screen to identify putative compounds able to rescue abnormal proteolysis in our disease model. These complementary techniques will enable the identification of novel disease-causing pathways and offer strategies for clinical intervention using …
-
Post-mortem Molecular Investigation: exploring genetic variation in CYP2D6 in deceased individuals at Salt River Mortuary
Drug use is a major burden in Cape Town, South Africa, and at times may be fatal. Individuals suspected to have demised from drug intoxication are referred for medico-legal investigation, in order for cause of death to be determined. Sometimes, it remains ambiguous as to whether the drug …
Page 1 of 2