Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Drug safety"”.
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Pharmacoepidemiology and Drug Safety: Examining Clinical Drug Trials Via Technology
This thesis provides a succinct analysis on the use of Information Technology (IT) in the fields of clinical research and pharmacoepidemiology. The primary research project explores a means of identifying a cost effective, and robust mechanism for conducting large scale clinical study using IT. The …
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Self-controlled methods for postmarketing drug safety surveillance in large-scale longitudinal data
A primary objective in postmarketing drug safety surveillance is to ascertain the relationship between time-varying drug exposures and adverse events (AEs) related to health outcomes. Surveillance can be based on longitudinal observational databases (LODs), which contain time-stamped patient-level …
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Exploring machine learning techniques using patient interactions in online health forums to classify drug safety
… collected from online message forums to predict drug safety using natural language processing and machine learning techniques. Drug safety is defined as any drug with an active safety alert from the US Food and Drug Administration (FDA). It is believed that this is the first exploration of …
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Optimising methodology for the elicitation of participant-reported data relating to drug safety in resource poor settings
… and elimination requires giving antimalarial drugs to asymptomatic or uninfected individuals. This shifts the harm-benefit balance and heightens the importance of accurately defining drug safety. Large data sets, including those pooled from multiple sources, are needed to understand uncommon …
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Development of harmonised approaches for detecting and recording participant-reported anti-malarial drug safety data: The Delphi process
… research participants is integral for evaluating drug safety. However, using different methods to question participants yields inconsistent results, compromising the interpretation, comparison and pooling of data across studies. This is particularly important given the widespread use of …
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Assessing the effectiveness and challenges of adverse drug reaction reporting systems: a systematic review
Adverse Drug Reaction (ADR) reporting is a process that includes recording adverse events that are suspected to have a relationship with the utilization of medicinal products, medical devices and cosmetics. However, persistent underreporting remains a major global concern that limits the early …
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NEW METHODS TO QUANTIFY METHIONINE OXIDATION AND PROTEIN GLYCOSYLATION AND A DE NOVO GLYCOPEPTIDE DECOY GENERATOR
… MS tools to characterize PTMs and ensure drug safety and efficacy. Methionine oxidation and glycosylation are two PTMs that can impact protein structure, stability and pharmokinetic properties. The highly spontaneous nature of methionine oxidation makes it challenging to analyze because …
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Data Mining for Signal Detection of Targeted Therapy Related Drug Toxicity in Breast Cancer Patients
… using claims data can improve post-marketing drug surveillance. The aim of this study is to compare two routinely used approaches, the proportional reporting ratio (PRR) and Gamma Poisson Shrinker (GPS) with a tree-based scan statistic (TBSS). Using data from the Texas Cancer Registry and …
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Data Mining for Signal Detection of Targeted Therapy Related Drug Toxicity in Breast Cancer Patients
… using claims data can improve post-marketing drug surveillance. The aim of this study is to compare two routinely used approaches, the proportional reporting ratio (PRR) and Gamma Poisson Shrinker (GPS) with a tree-based scan statistic (TBSS). Using data from the Texas Cancer Registry and …
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Development of a public health information infrastructure for postmarket evidence
… underutilized, and mismanaged to inform safety and comparative clinical effectiveness. Congress has tasked the Food and Drug Administration to build a public health information infrastructure for drug safety. It also has allotted $1.1 billion dollars in new spending for comparative …
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A case study of Vioxx using STAMP
… the application of a systems approach to drug safety. The recall of the prescription drug Vioxx (Rofecoxib) was used as a test case to study whether STAMP (Systems Theoretic Accident Model and Processes) could be used to outline the interactions between the different pharmaceutical system …
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Improving Treatment Outcomes For Veterans With Ptsd And Sleep Disturbance
… care, evidenced-based practice, and drug safety initiatives. </p>
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Informing Public Health Policy Design and Operations with Analytics: Methods and Applications
… pharmacovigilance, which is key to drug safety regulatory work. It presents PR1SM (Patients Really are 1st in Signal Management), an AI-based framework for identifying potential drug safety signals using post-marketing surveillance data. By structuring adverse event reports into …
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Paracetamol metabolism in postoperative patients
… this study, there was little evidence of their safety in surgical patients. When assessing drug safety in surgical patients a number of surgery and patient related factors influence results, and these must be considered. Methods: Major and intermediate surgical patients were recruited from two …
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Application of Hyper-geometric Hypothesis-based Quantication and Markov Blanket Feature Selection Methods to Generate Signals for Adverse Drug Reaction Detection
… is the science relating to all concerns about drug safety, especially ofmanaging the risk associated with medications. It serves as a complementary approach toclinical trial. Spontaneous Reporting Systems (SRS) had been constructed world-widely tofacilitate tracking the risk of post-marketing …
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Nutrient Drug Interaction Probability Scale (NDIPS): A Creation and Validation Process
Background:Drug-nutrient interactions (DNIs) are interactions between drugs and nutrients that can result in clinically relevant physiological alterations. Despite their potential impact, the importance of DNIs is heavily undervalued and overlooked. Evaluation of drug safety mainly focuses on …
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Engineering synthetic biology routes for protein analysis using microfluidic systems
… importance as subjects of physiological study,drug targets in high-throughput assays for drug discovery and drug safety screening1. Microfluidic devices can be used for manipulating and analysing proteins, greatly benefiting many of the applications mentioned. The ability to produce artificial …
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Renal Toxicity Warnings and Precautions of Drugs Marketed in the US
<p>INTRODUCTION: The use of drugs can lead to renal adverse effects prompting the need to include warnings and precautions on medication labels. Studies evaluating renal warnings and precautions need to be improved. This study assessed the characteristics of FDA renal toxicity warnings and …
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Development and validation of an in vitro human model of drug-induced vascular injury
Drug safety is a major cause of attrition in contemporary drug development. Many promising candidate drugs are terminated in the developmental process or withdrawn in the post-approval stage because of adverse drug reactions (ADRs). Among these, cardiovascular (CV) ADRs occur with a high incidence. …
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Using Cell Painting and Chemical Data for Small-molecule Bioactivity and Toxicity Prediction
… biological effects. Traditional approaches in drug discovery primarily rely on chemical structure fingerprints, which do not capture biological responses to compounds. By integrating cell morphology data, models offer a more comprehensive view, improving the prediction and accuracy for various …
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