Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 445 for “"Drug resistant"”.
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Extensively drug resistant tuberculosis in South Africa
… 115 patients, retrospectively, for adverse drug reactions (ADRs). It was found that a significant proportion of XDR-TB patients are HIV unrelated, and prognosis, regardless of HIV status, poor. Nevertheless, survival in HIV infected patients is better than previously reported, and treatment …
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TARGETING MULTI-DRUG RESISTANT PATHOGENS WITH NOVEL ANTIMICROBIAL PEPTIDES
… In the United States alone, antibiotic-resistant bacteria infect at least two million people and kill around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant Staphylococcus aureus (MRSA) according to a report published in …
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Hydrogel platform to investigate progression of drug-resistant glioblastoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
… nosocomial pathogens that can be intrinsically resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell membrane (CM) stressors like daptomycin (DAP), a front-line drug for multi-drug resistant …
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Age appropriate treatment of drug-resistant tuberculosis in South Africa
<p>Drug-resistant tuberculosis (DR-TB) is a threat to TB control globally. South Africa has the third highest epidemic of DR-TB – following only Russia and China, two much more populous countries. South Africa has stringent guidelines for treating DR-TB; however, little is known about adherence to …
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Optimising linezolid use for drug-resistant tuberculosis: pharmacokinetics, toxicity, and resistance
Background: Rifampicin-resistant tuberculosis (RR-TB) accounts for an expanding proportion of incident global TB cases and is a major barrier to global tuberculosis control. There is a need for more effective, safe, and well-tolerated drugs. Linezolid is a repurposed oxazolidinone antimicrobial …
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Novel therapeutics in the treatment of drug-resistant tuberculosis: a review
… of TB since the late 1940s, treatment duration, drug-resistance, and barriers to effective health delivery have thwarted efforts for elimination (and eventually, eradication). Here is a compendium of several novel therapies that are being considered to address this global pandemic.
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The Dynamics of Multi-Drug Resistant Organisms: Modeling Nosocomial Infection Control Measures
… the most efficient methods to combat it. Though drugs do exist to treat them, they are known to be highly resistant and have proven to be a reoccurring problem in hospitals, posing an increasing medical burden. Infection control measures have been implemented in order to reduce their impact and …
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Institutional and Patient Level Predictors of Multi-Drug Resistant Healthcare-Associated Infections
… infections (HAI) caused by multi-drug resistant organisms (MDRO) are an important patient safety concern resulting in a substantial financial and clinical burden. This dissertation aims to contribute to the evidence base on institutional and patient level factors that predict …
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… and other ESKAPE pathogens (including carbapenem-resistant Acinetobacter baumannii). Interestingly, these analogues were resistant to enzymatic degradation in the presence of recently reported D-stereoselective peptidases. <br/><br/>Secondly, brevicidine represents a promising candidate for …
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Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
… of new antimicrobials to treat these multidrug-resistant pathogens has not kept pace with the rapid emergence of resistance to current antimicrobials. Antimicrobial drug development through the traditional <em>de novo</em> process is a risky venture given the significant financial and time …
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Impact of endosomal recycling inhibitors on drug resistant and immune tolerant breast cancers
… women annually. There are a number of approved drugs on the market that have been developed or repurposed for the treatment of BC. However, a recurrent problem faced in the clinic is the emergence of drug resistance, which can be intrinsic or acquired. Prolonged periods of chemotherapeutics and …
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Time-resolved Resting-state fMRI of Brain States Associated with Drug-resistant Epilepsy
… of aberrant activity in individuals with drug-resistant epilepsy. Specifically, a dynamic functional connectivity analysis method is first used to determine the temporal dynamics of brain activity, followed by two unsupervised machine learning algorithms, k-means and hierarchical …
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Rev7 is a novel regulator of chemotherapeutic response in drug-resistant lung cancer
… is well known that intrinsic and acquired cancer drug resistance is a problem that severely limits the successful elimination of a wide range of malignancies. This point is particularly important in the context of genotoxic chemotherapies, because the DNA damaging agents used in cancer treatment …
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Biochemical, Structural, And Drug Design Studies Of Multi-Drug Resistant Hiv-1 Therapeutic Targets
… the structural mechanisms that lead to multi-drug resistance to HIV-1 protease and integrase inhibitors. </p> <p>Proper proteolytic processing of the HIV-1 Gag/Pol polyprotein is required for HIV infection and viral replication. This feature has made HIV-1 protease an attractive target for …
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INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS
… (mtMDM2) in driving OXPHOS regulation in TKI-resistant cancers through an interaction with TFAM. This phenomenon involves the mitochondrial-cytoplasm shuttling of MDM2 in a p53-independent manner, which leads to enhanced mitochondrial biogenesis via TFAM transcriptional machinery. Furthermore, …
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Exploring a Novel Anti-Gonococcal Compound for Combating Drug-Resistant <i>Neisseria gonorrhoeae</i>
… infertility if untreated. The rise in antibiotic-resistant gonorrhea underscores the urgent need for new therapeutics. To address this, suitable strains of N. gonorrhoeae for in vivo study were constructed. N. gonorrhoeae FA1090 is used in the mouse model of gonococcal infection due to its …
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Molecular differentiation of multi-drug resistant mycobacterium tuberculosis complex isolated from three provinces in Zambia
Multidrug-resistant tuberculosis (MDR-TB) is a disease caused by an acid-fast staining pathogenic bacterium, Mycobacterium tuberculosis that is resistant to at least isoniazid (INH) and rifampicin (RIF), the two most potent TB drugs. Drug-resistant tuberculosis poses a significant problem for …
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Molecular differentiation of multi-drug resistant mycobacterium tuberculosis complex isolated from three provinces in Zambia
Multidrug-resistant tuberculosis (MDR-TB) is a disease caused by an acid-fast staining pathogenic bacterium, Mycobacterium tuberculosis that is resistant to at least isoniazid (INH) and rifampicin (RIF), the two most potent TB drugs. Drug-resistant tuberculosis poses a significant problem for …
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