Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Drug resistance mutations"”.
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Analysis of cytomegalovirus UL97 drug resistance mutations in patients receiving Ganciclovir
Introduction: Cytomegalovirus (CMV) drug resistance mutations, because of the widespread use of ganciclovir, have been widely reported in international literature, particularly in the post-transplant setting. However, a genotypic assay to detect CMV drug resistance is not available in South Africa …
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Drug Resistance Mutations in Naive HIV-1 South African Patients, and Construction of Molecular Clones to Phenotype Putative Resistance Mutations
… is progressing data is required on patterns of resistance and evolution of resistance. Thirty protease (PR) and 31 reverse transcriptase (RT) amino acid sequences of HIV primary isolates from drug naNe patients from rural settings in South Africa were examined for resistance mutations. Samples …
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Language Models Predict Drug Resistance from Complex Sequence Variation
… to the development of vaccines, antiviral drugs, and antibiotics. Recently, neural language models trained on viral protein sequence evolution have shown promise in their ability to predict viral escape mutations, potentially enabling more intelligent therapeutic design [6]. Hie et al.’s …
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Interactions Between APOBEC3 and Murine Retroviruses: Mechanisms of Restriction and Drug Resistance
… synthesized during reverse transcription. These mutations can result in viral lethality via disruption of critical genes, but in some cases is insufficient to completely obstruct viral replication. This sublethal level of mutagenesis could aid in viral evolution. A cytidine deaminase-independent …
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Genetic characterization of human immunodeficiency virus from Northern South Africa
… HIV-1 genetic variants in sere-positive, drug na"fve populations from Limpopo Province where there is an estimated prevalence rate of about 19%. The molecular epidemiology of HIV-1 in two highly endemic areas in Limpopo Province of South Africa; mutations associated with drug resistance to …
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Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
… relevant problems: (i) prediction of drug resistance mutations that arise in response to four pre-clinical antibiotics, and (ii) the re-design of a monoclonal HIV antibody for improved potency and breadth of neutralization.</p>
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… most severe forms of human malaria; with multidrug resistance to modern antimalarials emerging and spreading in certain parasite populations, understanding the mechanisms for acquiring multidrug resistance will be key for predicting which genes may become important for clinical resistance in …
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Characterization of and risk factors for HIV-1 resistance mutations following first line antiretroviral failure in the southern African private sector
… years in South Africa. Many patients develop HIV drug resistance mutations when they fail first-line ART. The effect of different drug regimens and other patient related factors on drug resistant mutations selected at first line failure are not well characterised in Southern Africa with its …
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Biochemical, Structural, And Drug Design Studies Of Multi-Drug Resistant Hiv-1 Therapeutic Targets
<p>Protein point mutations acquired as a mechanism of survival against therapeutics cause structural changes that effect protein function and inhibitor binding. This work investigates the structural mechanisms that lead to multi-drug resistance to HIV-1 protease and integrase inhibitors. </p> …
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CRISPR-based functional genomics to study gene regulatory architecture and consequences of genetic variation
… variants are most often benign. However, some mutations are loss-of-function mutations, meaning that they interfere with and sometimes inhibit proper biological function. Understanding the functional consequences of these mutations is critical to understanding the genetic causes of diseases as …
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Molecular Effects of the Nampt Inhibitor FK866 on Leukemia Cells
… the dose-limiting toxicity, suggesting that this drug is a good candidate for clinical applications. We investigated the mechanism of action of FK866 in T-ALL derived cell lines as well as in primary leukemia cells. FK866-induced metabolic stress and NAMPT ablation elicited a strong arrest of …
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A Chemical-Genetic Map of Drug Resistance in Mycobacterium Tuberculosis
… can acquire an additional level of antibiotic resistance through specific chromosomal mutations. A better understanding of intrinsic and acquired drug resistance in Mtb is essential to develop faster treatments and better drug resistance diagnostics. We sought to understand the genetic basis …
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Human immunodeficiency virus type 1 diversity in patients initiating treatment in Northern South Africa
… in HIV prevalences and prevalences of HIV drug resistance within provinces and sub-regions of provinces in South Africa and to have an accurate perspective of the impact of universal test and treat (UTT) implementation, these geographical differences need to be investigated. This study …
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New approaches to antimalarial target deconvolution and measuring fitness effects of Plasmodium falciparum mutations implicated in drug resistance.
… control efforts face the persistent challenge of drug resistance and, to date, the malaria parasite has been able to develop resistance to almost every drug with which it has been challenged. One strategy to tackle the problem of drug resistance is to systematically identify new antimalarials to …