Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Drug release mechanisms"”.
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Elucidation of Drug Release Mechanisms in PLGA Microspheres
… to experimentally and theoretically elucidate mechanisms of drug release in PLGA microspheres. We showed the effect of microsphere size and presence of an antacid on the stability and release of plasmid DNA from PLGA microspheres. We demonstrated that the use of Mg(OH)2 as a stabilizing …
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The Degradation and Drug Release Mechanisms of Poly(ethylene glycol)-functionalised Poly(L-lactide) Polymers
… by hydrolysis. For certain medical device or drug delivery applications, it would be desirable to reduce this degradation time as strategies for tailoring degradation and drug release rates remain limited. This work aimed to examine a consistent series of polymers based on a large block of …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… (HPMC) were used as the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further modify drug release. The diclofenac sodium mini-matrices (4.5 mm …
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A thermal/thermo-mechanical and imaging study of component distribution and interaction in pharmaceutical film coats
… most important coating materials for controlled release formulations. To achieve the desirable drug release, the physical properties of EC films incorporated with various functional additives need to be fully understood. Therefore, the aim of this project is to characterize the physical …
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Electrodeless electro hydrodynamic printing of personalized drug dosages
There is compelling evidence that variability in drug efficacy in individuals depends on their genetic fingerprints. These observations have given rise to the concept of personalized therapy whose ultimate goal is to develop medicinal agents designed for each niche of the population and individual …
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Theoretical prediction of drug release in GI tract from spherical matrix systems
The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is …
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Study of drug delivery and cell encapsulation using biocompatible hydrogel
… are becoming an attractive means to mediate drug delivery or facilitate cell-based treatment of diseases. These particles are capable of maintaining drug stability/cell viability and providing specific drug release profiles. The selection of specific hydrogel and particle size depends on the …
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Development of solid lipid nanoparticles for sustained release of anticancer agents
… SLN has many advantageous such as controlled drug release, non-biotoxicity of the carrier, increased bioavailability of drug and lower overall cost. Techniques for the production of SLN, drug incorporation, loading capacity and drug release mechanisms are reviewed. The potential of SLN in …