Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Drug particles"”.
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Production of stable bcs class ii drug suspensions by melt emulsification and subsequent incorporation into polymer strip films
… the dissolution rate of poorly water-soluble drugs is to produce fine drug particles with increased surface area. This increase will lead to bioavailability enhancement. However, smaller drug particles are thermodynamically unstable and tend to aggregate or grow. Therefore, proper formulation …
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Manufacturing of a fast-dissolving dosage form - investigating powder handling and control of surface characteristics
… aqueous solution. To allow use of aqueous labile drugs and/or coated drug particles in the FDDF, the development of an alternative approach is sought i.e. that which allows independent dosing of drug powders and liquid components. The focus of this work is on the powder dosing aspect. A vacuum …
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Needle-free drug delivery using shock wave techniques
… use high-pressure compressed gas to accelerate drug particles 2 to 50 gpm in size to velocities of 200 to 1000 m/s. At these speeds the particles have sufficient momentum to penetrate the skin barrier and reach the viable epidermal layers. The devices offer much better control over the depth of …
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Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing. Chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations.
… under different experimental conditions. The drug produced by this method has been subject to a number of solid-phase analytical procedures designed to establish the crystal structure [X-ray powder diffraction (XRPD)], the structure and conformation [(FTIR), Fourier-transform Raman …
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Anti-solvent precipitation and subsequent film formation of hydrophobic drugs for drug delivery
It is estimated that about forty percent of the drug molecules being developed by the pharmaceutical industry are hydrophobic in nature, leading to poor water solubility and bioavailability in the gastrointestinal tract. Dissolution is a limiting factor in their in vivo performance, and increasing …
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A preliminary investigation of the sterile-filterability of BCS class II drug nanosuspensions prepared via wet stirred media milling
Drug nanoparticles can achieve targeting capabilities, enhanced dissolution rates and improved bioavailability when injected intravenously. Sterile filtration of drug nanoparticle suspensions (nanosuspensions) is critically needed for administration by intravenous delivery route. Avoiding gamma …
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Spray Techniques And Lung Cancer Chemoprevention
… current and former smokers. Directly delivering drugs to the lung could lead to a high concentration in the target organ with a lower dose compared to other means of administration. The primary advantages of aerosol delivery in treating lung diseases include improving the bioavailability of the …
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Batch and continuous production of stable dense suspensions of drug nanoparticles in a wet stirred media mill
… the bioavailability of poorly water-soluble drugs is to reduce particle size of drug crystals down to nanoscale via wet stirred media milling. An increase in total surface area per mass loading of the drug and specific surface area as well as reduced external mass transfer resistance allow a …
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The design and manufacture of immediate-release optimal solid dosage forms
… immediate-release solid dosage forms, from drug substance and excipient are: blending, wet granulating, drying, milling and screening, blending, tableting, coating, and so on. A new process, such as blending combined with solvent-less, multi-component injection-molding could greatly simplify …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
… is one of the most challenging aspects for drug commercialization and often the main reason of drug that do not reach to its full potential. Now nearly 60% new chemical entities possess solubility problems, whereas practically no drug products with less than 10 µg/ml solubility in 70’s or …
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Quality by Design Approach to Advanced Particle Engineering, Process Optimisation and Upscaling of Electrohydrodynamic Atomisation Technology
Particle engineering for drug delivery (DD) has gained enormous research interests in recent years, with continuous development of new technological platforms and improvement of existing ones. Unlike most other technologies, the electrohydrodynamic atomisation (EHDA), has been shown to have more …
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Stability and precipitation of diverse nanoparticles
… industries. The synthesis of micro-particles for hydrophobic drugs is effectively carried out via anti-solvent precipitation method. The formation of small particles in the precipitation method is strongly influenced by colloidal interactions, and therefore, dependent on the …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
Over recent years the delivery of nanosized drug particles has shown potential in improving bioavailability. Drug nanosizing is achieved by ¿top-down¿ and by ¿bottom-up¿ approaches. Owing to limitations associated with the top-down techniques, such as high energy input, electrostatic effects, broad …
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Understanding the Solid State, Solubility and Dissolution Behavior of Cefuroxime Axetil Diastereomers in Interactive Mixture Formulations
… behavior of a cephalosporin antibiotic prodrug, cefuroxime axetil (CFA). CFA is present in commercial products as a mixture of diastereomers, which commonly form eutectic mixtures. A phase diagram was constructed utilizing differential scanning calorimetry. It was observed that the …
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Experimental investigation of the effect of sonication on the precipitation of grieseofluvin by impinging jets
Almost 80% of drugs on the market are manufactured as solid dosage forms, such as tablets. Drug bioavailability increases as the particle size decreases and the surface area per unit volume of drug increases. Therefore, there is a keen interest by the pharmaceutical industry to develop techniques …
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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… of agglomeration of micronized API to API particles together within the tablet due to their high surface area and high surface free energy during compression. Increasing the particle size and decreasing the surface is generally expected to decrease the dissolution rate of the API.</p> …
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Direct Precipitation of Micron-Size Salbutamol Sulphate by Antisolvent Crystallization
Particle size is a key factor for inhalation drug powder as it determines the dosing efficiency, drug deposition in various regions, and the systemic absorption. This work aims to propose a direct approach to produce drug particles of desired size (between 1 and 5 ?m) through antisolvent …
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Processing and Characterization of Nanocomposite Fibers and Nanofibers for Structural and Biomedical Applications
… For fabrication of biocompatible nanofibers as drug delivery systems, electrospinning techniques were utilized to produce neat and drug-loaded nanofibers from biocompatible polymers of cellulose, cellulose Acetate (CA) and poly(ethylene oxide) (PEO). Loading of model anti-cancer drugs, Cisplatin …
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Development of supercritical processes for particle coating / encapsulation with polymers
… processes as novel coating approaches to coat particles from 20 nanometers to 500 microns with different polymers. Particle coating using different supercritical technologies of a modified rapid expansion of a supercritical solution (RESS) for particle coating and a supereritical antisolvent …
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An investigation into polymeric excipient-drug compatibility in solid-liquid formulations
… maintain good dispersibility of a given drug substance with known physico-chemical properties. This was achieved by quantifying the adsorption of different polymers onto a range of drug substances from different solvent environments and to establish which physico-chemical properties of …
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