Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Drug nanoparticles"”.
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Formulation and dissolution of polymer strip films for the delivery of poorly water-soluble drug nanoparticles
… have focused on incorporation of water-soluble drugs. The objective of this dissertation is to explore the robustness and versatility of the strip film platform for delivery of poorly water-soluble drug nanoparticles to ultimately develop a predictive model for drug release from such films. The …
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Batch and continuous production of stable dense suspensions of drug nanoparticles in a wet stirred media mill
… the bioavailability of poorly water-soluble drugs is to reduce particle size of drug crystals down to nanoscale via wet stirred media milling. An increase in total surface area per mass loading of the drug and specific surface area as well as reduced external mass transfer resistance allow a …
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Crystal engineering, Bio Pharmaceutics and Cell biology of active pharmaceutical ingredient (drug) nanoparticles. Formation and cell interaction of hydrocortisone and prednisolone nanoparticles.
… with the low bioavailability of hydrophobic drugs. In the first part of the current study, nanosuspensions of two of hydrophobic steroid drugs: hydrocortisone and prednisolone were produced. Nanosuspensions were prepared using a bottom-up approach: the anti-solvent precipitation method using …
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Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery
Amorphous solid dispersions of polysaccharide-drug nanoparticles were produced by a rapid precipitation process known as flash nanoprecipitation and the formulation process and properties of nanoparticles were investigated. In this thesis, several novel cellulose derivatives and a pullulan …
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A preliminary investigation of the sterile-filterability of BCS class II drug nanosuspensions prepared via wet stirred media milling
Drug nanoparticles can achieve targeting capabilities, enhanced dissolution rates and improved bioavailability when injected intravenously. Sterile filtration of drug nanoparticle suspensions (nanosuspensions) is critically needed for administration by intravenous delivery route. Avoiding gamma …
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Modified Release of Agglomerated Nano-Particles for Pulmonary Drug Delivery
… the pulmonary route presents many challenges. Nanoparticles tend to lack sufficient mass and are principally exhaled and not deposited in the lungs. However, they also tend to form aggregates or agglomerates to reduce the free energy of the system due to the large surface. Optimal deposition in …
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Drug delivery strategies to overcome ocular hypertension
… limitations, this thesis explores two innovative drug delivery strategies using anti-glaucoma drug-rich nanoparticles, called colloidal drug aggregates (CDAs). The first strategy involves a periocular hydrogel-nanoparticle composite designed for sustained, local delivery to the eye. Timolol …
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Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
… plays an important role in transforming a drug substance into the final drug product taken by a patient. It involves processes that combine an active pharmaceutical ingredient (API) and a mixture of inactive excipients into a final drug product with desired therapeutic effects and physical …
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… enhancement of poorly water-soluble drugs. While they both have several advantages-disadvantages, a scientific comparative assessment of their drug release performance and dissolution mechanisms at different drug doses is not available. With the goal of addressing this issue, the …
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Fabrication of Polymersomes using Microfluidic Devices
… presented and its application for fabricating drug nanoparticles from hydrophobic active pharmaceutical ingredients (APIs) was demonstrated.