Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Drug monitoring"”.
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Development of biosensors for biomarker detection and clinical therapeutic drug monitoring
… remains a gap in the effective diagnosis and the monitoring of diseases to achieve therapeutic success. Current laboratory analysis methods such as mass spectrometry, HPLC and MRI are complex, have high turnaround time, require expertise, are expensive and restricted to laboratory setting. In this …
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Therapeutisches Drug-Monitoring von Nevirapin : Bedeutung in der Therapie der HIV-Infektion
Nevirapin ist ein Nicht-Nukleosidaler Reverse Transkriptase Inhibitor, welcher seit 1996 in der Therapie der HIV-Infektion eingesetzt wird. Im wissenschaftlichen Labor des Schwerpunktes Hepatologie/Infektiologie der Medizinischen Klinik und Poliklinik II des Universitätsklinikums Würzburg werden im …
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The clinical role of therapeutic drug monitoring of antiretrovirals : a Cochrane systematic review
The objective of this study is to evaluate whether ARV TDM reduces mortality and morbidity of adult patients on cART.
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Schnelles und zuverlässiges therapeutisches Drug-Monitoring mit HPLC-UV und LC/LC-MS/MS aus komplexen Matrizes
Voraussetzung für das therapeutische Drug-Monitoring ist, dass die analytische Methode schnell qualitativ hochwertige Ergebnisse liefert. Ausgehend von diesen Kriterien wurden Nachweismethoden für Antimykotika und Antibiotika entwickelt und sowohl in klinischer Routine als auch in klinischer …
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Introducing clinical pharmacology to hepatitis C therapy. Lessons learned from studies on therapeutic drug monitoring and drug-drug interactions
Contains fulltext : 142579.pdf (Publisher’s version ) (Open Access)
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Therapeutic drug monitoring of anti-TNF biologics in patients with Crohn's disease at Groote Schuur Hospital, Cape Town, South Africa
… Crohn's disease (CD). The advent of Therapeutic Drug monitoring (TDM) in recent years has allowed further optimisation of their use. TDM involves the measurement of serum trough levels (TLs) and anti-drug antibodies (ADAs), with higher serum drug concentrations and the absence of ADAs associated …
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Using electronic methods of adherence monitoring and therapeutic drug monitoring (TDM) to eliminate discordance between antiretroviral adherence and virological failure
… to improve outcomes. We explored ideal adherence monitoring methodology for a large public sector ART clinic in Cape Town. Methods: We designed a randomised controlled study for ART-naïve individuals to determine whether text messaging after a missed dose would improve adherence recorded by an …
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Development of novel extraction and separation methods for the determination of anthracyclines and taxanes simultaneously from biological matrices
… to patients and that accurate measurement of drug levels during chemotherapy is proven to be more beneficial to patients, currently no chromatographic method exists for the measurement of any anthracycline and taxane drugs in a single assay. It would be useful to carry out therapeutic drug …
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Advancing and expanding siRNA and saRNA therapeutics applications through chemical modifications
… that could potentially allow for real-time drug monitoring during cancer treatment. The third goal focused on discovering nuclease-resistant and active saRNAs targeting STING, which is a potential target for the treatment of solid tumors. In this study, a library of chemically modified saRNA …
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Optimisation of analytical methods for monitoring monoclonal antibody therapy in Inflammatory Bowel Disease
… Infliximab and adalimumab. However, low drug levels and immunogenicity (development of anti-drug antibodies) are associated with treatment failure. Therapeutic drug monitoring, using drug and anti-drug antibody measurements improves treatment outcomes. This thesis aims to optimise and …
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MEDICAL CANNABIS USE AMONG CHRONIC PAIN PATIENTS AND ASSOCIATIONS WITH PRESCRIPTION OPIOID USE: A RETROSPECTIVE STUDY
… with information from the State Prescription Drug Monitoring Program and collected at time of initial certification and at six months post-certification. Results indicated that 91% of patients used their certification to buy medical cannabis at least once within the first six months. …
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Innovative analytical methods for Central Nervous System Drug analysis in biological fluids
… number of central nervous system (CNS) drugs have been approved and introduced on the market for the treatment of many psychiatric and neurological disorders, including psychosis, depression, Parkinson disease and epilepsy. Despite the great advancements obtained in the treatment of CNS …
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Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
… of a “standardized” dosing strategy. Therapeutic drug monitoring (TDM) provides a tailored treatment for individuals while avoiding adverse side effects from compounds with a narrow therapeutic window where elevated concentrations of a drug cause organ toxicity. This strategy involves accurately …
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Awareness And Utilization Of The Ohio Automated Rx Reporting System By Physician Assistants
… complaints increase, so does the potential for drug abuse/misuse. Prescription drug monitoring programs (PDMPs) are active in 49 of the 50 states to assist providers in recognizing drug abuse/misuse. There is no clear standardization of who utilizes the PDMP and how. Little is still known about …
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Development of a HPLC method for the determination of methotrexate (MTX) and MTX-polyglutamates of red blood cells: A dissertation submitted in partial fulfilment of the requirements for the Degree of Bachelor of Science with Honours at Lincoln University
… arthritis (RA). Patient response to, the drug and development of side effects are poorly understood. There is large a variation in clinical response between patients and this influences the dose requirement. Therefore, there is a need for therapeutic drug monitoring to ascertain clinical …
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Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
… und Doxorubicinol ein therapeutisches Drug Monitoring mit nachfolgender Dosis-Anpassung bei außergewöhnlich hohen oder niedrigen Plasmakonzentrationen sinnvoll sein.
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Der stereoselektive Nachweis von Levo- und Dextromethadon in Blutproben von lebenden und verstorbenen Drogenabhängigen
… von Levomethadon sowohl zum therapeutischen drug monitoring als auch zur forensischen Diagnostik.
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Characteristics That Discriminate Between Successful and Unsuccessful Drug Withdrawal Candidates Among Mentally Retarded Persons (Neuroleptic, Psychotropic, Major Tranquilizers)
… of mentally retarded persons with neurolepic drugs is questionable. Many mentally retarded persons receiving neuroleptics should not remain on these drugs because the drugs have not suppressed maladaptive behaviors and have in some cases, interfered with learning. Unfortunately, little …
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