Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 96 for “"Drug metabolism"”.
-
Effect of obesity on hepatic drug metabolism
… thesis was to determine the effect of obesity on drug metabolism and evaluate methods that could potentially predict changes in pharmacokinetics in the obese population. The impact of obesity on drug metabolism in children has not been determined and our clinical study (Chapter 2) was the first of …
-
Dynamics of protein-membrane interactions in drug metabolism and cancer
… within the membrane. Energy transduction, drug metabolism, and signaling represent some of these dynamic processes which require proteins to interact with cell membranes. One must therefore study protein-membrane interactions deeply to fully understand how organisms function. For example, …
-
Engineered microtissue platforms for modeling human pathophysiology and drug metabolism
Over 50% of all drug candidates entering clinical trials are abandoned due to insufficient efficacy or unexpected safety issues despite extensive pre-clinical testing. Liver metabolites that cause toxicity or other side effects cannot always be predicted in animals, in part because of …
-
BIOCHEMICAL BASIS OF IMPAIRED HEPATIC MICROSOMAL DRUG METABOLISM IN THE NEONATE.
BIOCHEMICAL BASIS OF IMPAIRED HEPATIC MICROSOMAL DRUG METABOLISM IN THE NEONATE.
-
Studies on drug metabolism by use of isolated rat liver cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
The influence of genetic polymorphisms and natural health products on drug metabolism
… activities of two major components involved in drug metabolism, P-glycoprotein (P-gp) and members of the cytochrome P450 oxidase (CYP) family were studied. This investigation specifically examined the influence of polymorphisms within the ABCB1 gene on P-gp efflux activity and expression. …
-
Application of capillary zone electrophoresis methods for the investigation of in vitro drug metabolism.
… of HPLC and their application to in vitro metabolism. In vitro metabolism looks at the metabolic fate of a drug, in this case by incubation with a suspension of the microsomal rat liver fraction. This method was chosen as it can generate a series of samples taken from a bulk incubation to …
-
Investigation of ocular drug metabolism and pharmacokinetics using multi-omics and in-situ microdialysis
Ocular drug disposition is governed by a complex interplay of anatomical barriers, local metabolic activity, transporter expression, and tissue-specific physiological processes. However, quantitative understanding of drug-metabolizing enzymes and transporters in ocular tissues remains limited, …
-
Myotonic dystrophy type one causes dysregulation of drug metabolism and fatty accumulation in the liver
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
-
P450 biochips : development of a protein microarray platform for investigating cytochrome P450 clinical drug metabolism
This thesis describes the development of a novel cytochrome P450 array format, the P450 Biochip that allows quantitative and truly high-throughput measurement of cytochrome P450-mediated turnover reactions in sub-nanolitre volumes.
-
Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicities
… study of inherited factors that affect the human drug response. Many pharmacogenetie studies have been published since 1995 and have focussed on the principal enzyme family involved in drug metabolism, the cytochrome P450 family, particularly cytochrome P4502C9 and 2C19. In order to investigate …
-
A microfabricated 3D tissue engineered "Liver on a Chip" : information content assays for in vitro drug metabolism studies
… in culture formats amenable to routine use in drug development. The in vivo microenvironment of hepatocytes in the liver capillary bed includes signaling mechanisms mediated by cell-cell and cell-matrix interactions, soluble factors, and mechanical forces. This thesis focuses on the design, …
-
Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… SCD are subjected to long term administration of drugs and there is a limited data on pharmacogenomics of SCD therapeutics. Vaso-occlusive crisis (VOC) are the main clinical events of SCD and are associated with recurrent and long-term use of antalgics/opioids and HU. This project aimed to …
-
Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions
… for decades, essential information about their metabolism is not available. Lack of knowledge about the metabolites formed in the body upon administration of the aforementioned medications as well as the enzymes involved in their metabolism limits key information needed to make sound medical …
-
Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms
… They are responsible for over 80% of primary metabolism of currently available drugs and are therefore central to its medical importance. Investigating the effects of these enzymes on drugs by metabolite detection and kinetic studies is a step forward to the vision of personalised medicine. …
-
Effect of cell- and species-differences in the expression of drug metabolism enzymes on chemical-induced injury to the rat and human kidney
Differences in the expression of drug metabolizing enzymes between cells of the rat and human kidney on chemical-induced nephrotoxicity were studied. Rat renal proximal tubular (rPT) and distal tubular (rDT) cells differed in their susceptibility to trichloroethylene (Tri) and thiophene-containing …
-
Mathematical modelling of drug metabolism : using <em>in silico</em> techniques to investigate the cytochrome P450 enzyme system in hepatic reductase null mice
… set up can be used to replace animal testing for drugs. As such modelling techniques need to be developed to reduce dependence on animals for validation of pharmacological efficacy. The work within this thesis shows that computational methods can be used to model biological and medical problems …
-
In vitro metabolism of tetrazole aminoquinolines and derivatives of metergoline and fusidic acid
Drug metabolism is recognised as a key component of the drug discovery and development process. It exerts an influence on the action, duration of action and toxicity of a drug in vivo. The integration of drug metabolism studies is therefore crucial to compound progression through the various stages …
Page 1 of 5