Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 124 for “"Drug interactions"”.
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Drug-drug interactions between antiretrovirals and bedaquiline
… for multiple reasons, including potential drug-interactions. Drug-resistant TB is difficult to treat and is associated with high treatment failure rates, mainly because the antimycobacterial drugs currently available are ineffective against drug-resistant TB. Bedaquiline is a new …
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Predicting drug interactions with a three level causal model
… for predicting qualitative pharmacodynamic interactions of the cardiovascular system is described. TLCM traces causal paths of drug action through up to three levels of drug action. The three levels which are molecular/receptor level, physiological level and clinical level provide both deep …
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Mathematical modelling of host-disease-drug interactions in HIV disease
… that the virus exhibits by the accumulation of drug-resistant mutations in its genome. Current therapeutic strategies aim at achieving and maintaining a low viral burden and typically involve multiple drugs. The choice of optimal combinations of these drugs is crucial, particularly in the …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously …
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FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
… and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs (buspirone, caffeine, dextromethorphan and losartan) used to probe cytochrome P450 (CYP) activities, a significant decrease in …
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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression of drug transporters can prove to be of utmost importance in drug delivery or drug design by targeting specific transporter proteins. …
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Effect of berberine on in vitro metabolism of sulfonylureas: a herb-drug interactions study
… to control their blood glucose. Potential interactions at uptake of compounds through P-gp, a 170 kDa ATP-dependent glycoprotein and drug transporter can affect their absorption. Furthermore, competitive binding at the catalytic sites of metabolic enzymes of drug and herb may mutually …
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Nonlinear mixed-effects modelling of drug-drug interactions between antiretroviral therapy and tuberculosis treatment
… treatment of HIV and TB often results in drug-drug interactions (DDIs), mediated especially by rifampicin, a key component of the TB regimen and potent enzyme and transporter inducer. These DDIs may compromise treatment safety and efficacy, potentially leading to therapeutic failure and …
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Quantitative Structure-Activity Relationship Modeling to Predict Drug-Drug Interactions Between Acetaminophen and Ingredients in Energy Drinks
The evaluation of drug-drug interactions (DDI) is a crucial step in pharmaceutical drug discovery and design. Unfortunately, if adverse effects are to occur between the co-administration of two or more drugs, they are often difficult to test for. Traditional methods rely on in vitro studies as a …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… often challenging because of the potential for drug-drug interactions. Dolutegravir-based regimens are now the preferred first-line option for the management of HIV. Therefore, many African countries have transitioned most PLWH from efavirenz- to dolutegravir-based regimens. A fixed-dose …
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Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations
… those with co-morbidities requiring additional drug treatments, and those with drug-resistant strains. This leaves many unanswered questions surrounding the management of TB, HIV, and TB/HIV in these vulnerable subpopulations. In this thesis, we utilise population pharmacokinetics and …
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Development of a TSM Biosensor for the Determination of DNA- Drug Interactions: A Novel Method to Assist Drug Development
… and kinetics of binding of chemotherapeutic drugs to DNA are generally time consuming and/or expensive. Moreoxer. a combination of approaches is required if both the mechanism and the kinetics of binding are to he determined, e.g. LJV spectroscopy can be used to determine the kinetics of …
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Introducing clinical pharmacology to hepatitis C therapy. Lessons learned from studies on therapeutic drug monitoring and drug-drug interactions
Contains fulltext : 142579.pdf (Publisher’s version ) (Open Access)
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Vitamin D Levels Affect Survival in a BCR-ABL Acute Lymphoblastic Leukemia Mouse Model but Do Not Cause Vitamin-Drug Interactions
… inducers or inhibitors if co-administered with drugs that are CYP3A4 substrates lead to marked drug-drug interactions. Because vitamin D is known to regulate intestinal CYP3A expression and gut CYP3A expression plays an important role in pre-systemic metabolism of CYP3A drugs, we determined the …
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Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions
… will ensure safe and effective use of these drugs and hence enhance the clinical outcome. The thesis starts with an introductory chapter which comprises a comprehensive literature review on gastroparesis and the available pharmacological treatment options. The chapter also emphasizes the …
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EXPANDING THE TOOLKIT: STRUCTURE, DYNAMICS, AND DRUG INTERACTIONS OF THE “PRIMING LOOP” FROM HEPATITIS B VIRUS PRE-GENOMIC RNA BY SOLUTION NMR SPECTROSCOPY
… can probe the structure, dynamics, and interactions of RNA in solution at atomic resolution, opening the door to their functional understanding. However, NMR analysis of RNA – with only four unique ribonucleotide building blocks – suffers from spectral crowding and broad linewidths, …
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Population pharmacokinetic models describing drug-drug interactions and variability in HIV infected South Africans on protease inhibitor-based antiretroviral regimens with and without tuberculosis
… reduced adherence leads to the development of drug resistance. The projects in this thesis were designed to characterize the population pharmacokinetic parameters of lopinavir and ritonavir in HIV infected South Africans, to account for the drug-drug interactions between lopinavir, ritonavir …
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