Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Drug formulations"”.
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Towards Data-driven Development of Advanced Drug Formulations Leveraging Machine Learning and Experimental Automation
The majority of new drugs fail during clinical trials, primarily due to ineffective performance, unacceptable side effects, and poor drug-like properties. Typically, many of these issues can be mitigated by developing fully optimized drug formulations. The development of these formulations usually …
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Differential spectrophotometric analysis of intravenous admixtures containing metaraminol with selected corticosteroids
… admixtures consisting of one or more drug formulations, diluted in a large volume of intravenous solution, are used extensively in current medical practice. Development of reliable methods to predict the compatibility of the admixture components is essential as a guide for their …
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Enhancing the injectability of high concentration drugs via core annular flows
High concentration drug formulations that can be delivered via subcutaneous injections offer tremendous benefits to global health, but their high viscosity prevents injectability through medical needles. Current approaches to solve this problem face several challenges ranging from cross …
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Effect of Mesoporous Silica-Loaded Anticancer Drugs on 3D vs 2D Models of Colon Cancer Cells
… the development of nanocarriers for enhanced drug delivery. Furthermore, tumour resistance to anticancer drugs warrants evaluation in a suitable 3D model mimicking in vivo tumours. This study investigated the impact of a potential chalcone-based anticancer drug, DMU121, and oxaliplatin (OXA) …
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Ingestible capsules for therapeutic injections in the gastrointestinal tract
Macromolecule drugs such as insulin have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limits their administration to parenteral routes. An oral biologic delivery system must aid in both …
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Engineering physico-chemical interactions across drug delivery, agriculture and carbon capture
… limits the efficiency of several phenomena. In drug delivery, viscous formulations are difficult to inject through medical needles as the no-slip boundary condition between the needle and the viscous drug product greatly resists fluid flow. In agriculture, the inherent water repellency of plant …
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Development of fixed dose combinations using advanced engineering technologies
Traditionally manufacturing of drug formulations has been controlled by an established regulatory framework which ensured that final product quality was safeguarded. By carrying out testing of batch-based operations and comparison with raw material and end-product characteristics this quality is …
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Controlling the Stability of Colloidal Drug Aggregates for Chemotherapeutic Delivery
… aggregation presents a significant nuisance in drug discovery programs; the self-assembly of hydrophobic compounds into colloidal particles leads to numerous artifactual results in screening assays. In biochemical enzyme inhibition assays colloids non-specifically adsorb proteins leading to …
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Minimizing Avoidable Interruptions During Medication Administration
… of weight-based dosing, lack of alternative drug formulations, or small drug volumes, three times as many adverse drug events are reported in the pediatric population due to medication administration errors. To address these interrupting phone calls, a Unit Clerk Phone Package with four tools …
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The Effect of Crystalline and Amorphous Lactose on Mechanical Properties of Roller Compaction Ribbons and Tablets
… properties that facilitate performance within formulations. Lactose is infrequently used in large concentrations for dry granulation processes because alpha-lactose monohydrate exhibits relatively poor binding properties and consolidates mainly by fragmentation due to its `brittleness'. Though …
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Bio-Inspired and Nanotechnology-Enabled Drug Delivery for Diabetes and Brain Cancer
Nanotechnology-enabled drug delivery systems, inspired by biological processes, were developed to overcome current treatment challenges facing diabetes and cancer patients. Two different systems were developed. The first system, an implantable closed-loop insulin delivery device, utilizes …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… thesis is concerned with the prediction of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… thesis is concerned with the prediction of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific …
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Synthesis and Applications of Cellulose Derivatives for Drug Delivery
… to produce new derivatives of cellulose for drug delivery applications, methods were developed to regioselectively modify C-6 halo cellulose esters to produce cationic derivatives via nucleophilic substitution. Reaction of C-6 substituted bromo and iodo cellulose with trialkylated amines and …
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Coupling qualitative and quantitative analyses of pharmaceutical materials enabled by second harmonic generation microscopy
… of crystallinity is critical throughout the drug development process. From the initial establishment of an active pharmaceutical ingredient’s (API) crystal structure to stability testing and quality control, the phase of an API affects the solubility, bioavailability, stability, and efficacy …
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Development and Evaluation of a Small Volume Liquid Impaction Surface (SVLIS) in the Next Generation Impactor (NGI)
… dissolution and absorption of orally inhaled drug formulations. Models that integrate the study of at least two of these processes would be better able to simulate conditions in vivo. This thesis describes the design and evaluation of a Small Volume Liquid Impaction Surface (SVLIS) in the Next …
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Towards an improved ocular drug delivery system
… which will improve the efficiency of ocular drug delivery systems. Initially, it was necessary to review the information available on the nature of the tear fluid and its relationship with the eye. An extensive survey of the relevant literature was made. There is a common belief in the …
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Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
… plays an important role in transforming a drug substance into the final drug product taken by a patient. It involves processes that combine an active pharmaceutical ingredient (API) and a mixture of inactive excipients into a final drug product with desired therapeutic effects and physical …
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Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo
… of this therapy are not optimised including; drug choice (Dexamethasone, Dex, or Betamethasone, Beta), and drug formulation. There is increasing animal and human data that suggest exposure to high doses of synthetic glucocorticoids may have a detrimental effect on the fetal cardiovascular …
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