Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Drug formulation"”.
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Self-assembled peptide as a long-acting drug formulation
… peptides as a prolonged-activity, self-mediated drug delivery system for subcutaneous injection of pharmaceutically active drugs. Oxyntomodulin is used as a model peptide due to previously futile attempts at finding long-acting analogues, and Oxyntomodulin’s so far unreported self-assembly …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… thesis is concerned with the prediction of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… thesis is concerned with the prediction of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific …
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Combinatorial therapy for triple negative breast cancer and the effect of nanoscale surfaces
… this aim, we have generated a combinatorial drug formulation comprising DNA damage repair agents, along with inhibitors for STAT-3 for an optimized effect. The combinatorial formulation includes nifuroxazide, a known STAT-3 inhibitor, and amonafide, an agent known to exert its effect through …
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Evaluation of predictive computational modelling in biologic formulation development
… the power of computational modelling for protein drug formulation has numerous, currently unrealized, benefits. This project aims to be the first step in the development of a high throughput predictive computational model to screen for excipients that would decrease protein aggregation in solution …
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Towards Data-driven Development of Advanced Drug Formulations Leveraging Machine Learning and Experimental Automation
The majority of new drugs fail during clinical trials, primarily due to ineffective performance, unacceptable side effects, and poor drug-like properties. Typically, many of these issues can be mitigated by developing fully optimized drug formulations. The development of these formulations usually …
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Paclitaxel nanoparticles for breast cancer therapy in pregnancy
… on fetal health. A number of new paclitaxel nanoformulations for the treatment of breast cancer are entering clinical studies or are commercially available, but whether or not these formulations cause differences in transplacental transfer and, ultimately, fetal exposure remains to be seen. Here, …
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A foe-inspired friend: Constructing a tumor tissue-mimicking biomaterial to study intratumoral drug transport
… tumor microenvironment and its implementation on drug screening of new anticancer therapies is an active challenge that sits at the interface of biomaterials and cancer biology. As recent clinical successes of human intratumoral therapies stimulate research on intratumoral delivery, a need for an …
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Controlling the Stability of Colloidal Drug Aggregates for Chemotherapeutic Delivery
… aggregation presents a significant nuisance in drug discovery programs; the self-assembly of hydrophobic compounds into colloidal particles leads to numerous artifactual results in screening assays. In biochemical enzyme inhibition assays colloids non-specifically adsorb proteins leading to …
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Applications of modifiers in supercritical fluid extraction and chromatography
… the extraction of the active components from a drug formulation. The separation of some compounds of pharmaceutical interest was also explored, where the addition of modifier, and in some cases an additive, was required to elute compounds from the chromatographic column.
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Bioresorbable Osmotic Pump for Long–term Contraception
… effective reversible option due to their high drug adherence. However, the implants currently on the market are mostly limited to non-bioresorbable matrix-diffusion systems. These Fickian diffusion-based systems raise problems like inconstant release rates that compromise their long-term …
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Applications of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) in pharmaceutical analysis
… practices for powder, pellet, tablet and liquid formulations called Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS). BARDS is an innovative technique that can economise production processes for drug formulations. BARDS is based on reproducible changes in a solvent's compressibility …
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IN VITRO LUNG EPITHELIAL CELL TRANSPORT AND ANTI-INFLAMMATORY ACTIVITY FOR LIPOSOMAL CIPROFLOXACIN
… the importance of cell membrane-associated drug/formulation on the inhibitory activities for Lipo-CPFX. Upon 24 h transport, Lipo-CPFX retained 79.0 % of the 4 µg dose on the mucosal cell surface, which was 1.9-times greater than 40.7 % for CPFX. As a result, when LPS was added at 24 h of …
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Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations
… studies concerning the stability of the drug substances betamethasone 17-valerate and fusidic acid hemihydrate in topical pharmaceutical formulations. In particular, the work concentrates on formulation factors affecting the intra-molecular isomerisation of betamethasone 17-valerate to …
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Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo
… of this therapy are not optimised including; drug choice (Dexamethasone, Dex, or Betamethasone, Beta), and drug formulation. There is increasing animal and human data that suggest exposure to high doses of synthetic glucocorticoids may have a detrimental effect on the fetal cardiovascular …
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Performance of two different types of inhalers. Influence of flow and spacer on emitted dose and aerodynamic characterisation.
… around examination of three mainstream inhaled drugs Formoterol, Budesonide and Beclomethasone for treatment of asthma and COPD. The areas investigated are these which have been raised in reports and studies, where there are concern, for drug use and assessment of their use. In reporting this …
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Injectable hydrogels for the improved delivery of treatments in spinal cord injury
… reverse paralysis, a number of biomacromolecule drug candidates in the form of proteins, enzymes and monoclonal antibodies have demonstrated restoration of function in studies with SC animal models. However, the inability to address drug formulation stability issues and overcome delivery barriers …
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Importance of hierarchical interactions in concentrated protein systems
… rRNA. Protein aggregation is a major problem in drug formulation for the pharmaceutical industry. Antibody molecules form elongated complexes due the interaction between their domains. These complexes entangle with each other causing a sharp rise in viscosity of solution. To reduce the production …
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Modification of the Next Generation Impactor and Incorporation of Bacterial Cultures as an In Vitro Pneumonia Model
… to the lungs, with the development of new drug formulations. Despite the development of new products and potential for improved therapy, inhaled antibiotics, especially for the treatment of pneumonias, are under-utilized. This is mainly due to the poor correlation between in vitro and in …
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