Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Drug eluting stents"”.
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Remote controlled drug release in drug-eluting stents
… the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
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Eine Stentimplantation außerhalb der FDA-Indikationen für DES ist unabhängig von der Wahl des Stenttyps mit einer erhöhten Stentthromboserate verbunden
For decades, implantation of stents in coronary lesions after baloon dilatation has been the gold standard therapy in stenotic coronary artery disease. With the use of bare-metal stents, the cardiologist often saw an instent restenosis, which led to the invention of drug-eluting-stents. …
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Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery
Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what drives the safety and efficacy of these devices. The goal of this thesis was …
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A system for impedance characterization of coronary stents
Stents are used to re-open and maintain flow in diseased coronary arteries in patients suffering from coronary heart disease. Drug-eluting stents are now the preferred choice of stent but their performance is still limited by delayed healing of the important endothelial cell layer that lines the …
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Novel strategies for optimising drug release from medicinal implants
… a neointima, which renarrows the artery lumen. Drug-eluting stents (DES) release drugs to inhibit SMC proliferation and have been very successful in reducing ISR rates. However, they are not suitable for every patient group and lesion type, and may induce delayed healing of the endothelium, …
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Hochfrequenzrotablation zur Behandlung von Restenosen in Koronarstents
… mostly due to the increased rate of coronary stents being implemented. Next to the tissue debulking techniques, intra-coronary brachytherapy and the usage of drug-eluting stents show a promising reduction of these iatrogen lesions recently. Methods: RA with adjunct angioplasty was used in 40 …
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Hemocompatible polymer thin films fabricated by Electrostatic Self-Assembly (ESA)
… of stent is restenosis. Current development of drug-eluting stents shows successfully reduce the occurrence of restenosis. Other than using drugs, electrostatic self assembled (ESAd) thin films may be the potential candidates to prevent restenosis. ESA is a process to fabricate thin films bases …
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Computational model of local intravascular drug delivery
Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical to examine factors that alter local biologic outcome. The central hypothesis of …
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Biorubber (PGS) : evaluation of a novel biodegradable elastomer
… U.S. for 2004. Another promising field involves drug delivery, particularly in combination devices like drug-eluting stents. The potential non-medical applications are biodegradable rubbish bags, the absorbent material used in sanitary napkins or diapers, and even fishing lure or chewing gum.
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Specific and general binding in arterial drug delivery
Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different specific binding targets yield drastically different tissue transport, …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local delivery of a hydrophobic …
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Construction of nano-assembled microcapsules embedded with gold nanoparticles for use in novel drug delivery systems
Coronary stents have changed the way in which coronary artery diseases are managed. Although bare-metal stents can be traced back to 1994, long term efficacy of these stents has been shattered by ISR (In-Stent restenosis) and late stent thrombosis. Research on finding a solution to these issues has …
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Endothelial cell plasticity as a marker of vascular disease and predictor of adverse outcomes to stress
… between EC dynamism and antiproliferative drugs, in particular rapamycin and paclitaxel – the agents released from drug-eluting stents, showing that biomechanical cues from flow dominate EC responses, potentially limiting drug efficacy in regions of disturbed flow. Aim 3, extends the …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… coronary intervention (PCI) and the placement of drug eluting stents (DES) coated with pan-cellular anti-proliferative agents. Although these approaches are effective, in-stent restenosis and thrombosis remain problematic, in part due to limited re-endothelialization. Thus, DESs coated with drugs …
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Developing polypyrrole coated coronary stents for extended release of Sirolimus
… worldwide. Amongst all the treatment options, drug-eluting stents (DES) are thought to be the most effective method of treatment for the majority of patients. Despite the early success of DES in treating coronary artery disease, concerns and uncertainties were raised. The most critical …
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Vergleichende Untersuchung zur Nutzung von Paclitaxel-beschichteten-Stents und unbeschichteten Stents zur Behandlung stenosierter Venenbypässe
… data on the clinical and angiographic success of drug-eluting stents in saphenous vein grafts. This multicenter study sought to define the follow-up clinical and angiographic results after implantation of paclitaxel-eluting stents (PES) in stenotic saphenous vein grafts in comparison to treatment …
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Evaluation eines Tacrolimus-beschichteten Stents zur Prävention der Restenosierung im diabetischen Tiermodell
… processes. Recently, a number of studies using drug-eluting stents have been performed, since the local and sustained application of antiproliferativ drugs can achieve a decrease in restenosis rates. Tacrolimus, a Rapamycin-derivative, owns, as an immunsuppressiv drug, antiinflammatoric as well …
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
… This inflammatory process occurs in arterial stents and synthetic grafts as well; however restenosis rates in stents have been significantly reduced through the use of Drug eluting stents (DES), which contain antiproliferative agents that suppress the inflammatory process after implantation …
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
… scientists are facing today is discovering new drugs to protect the heart against cellular damage caused by ischemia-reperfusion injury (I-R injury). Rapamycin is one such drug that has been shown to protect the heart against ischemia-induced cellular injury. Rapamycin(sirolimus) inhibits …
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