Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Drug distribution"”.
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Factors affecting drug distribution in granules.
… and processing variables affecting the distribution of a low dose drug in granules prepared by the massing and screening method have been investigated. Five granule formulations were used to elucidate the effect of the "relative solubilities" on the drug distribution in granules. These …
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Substance Use and Drug Distribution at the Individual Level: A Grounded Theory Approach
… occurs among individuals that distribute drugs and there is a limited amount of research that has examined both use and distribution. A grounded theory approach was used to develop a framework for analyzing relationships between use and distribution behaviors. 15 participants (five female, …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local delivery of a hydrophobic …
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Melhoria do processo de distribuição de medicamentos para pacientes internados: estudo de caso da farmácia do instituto central do HCFMUSP
… activities related to the medication process. Drug distribution has impacts on the success of therapy and on hospital costs, requiring continuous evaluation. Redesigning this process justifies the applicability of this study, which aims to assess bottlenecks and to propose improvements in the …
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EXPLORING HETEROSTRUCTURED UPCONVERSION NANOPARTICLES: FROM RATIONAL PARTICLE ENGINEERING TO BIOMEDICAL APPLICATIONS
… limited quantum efficiency but also has a poor drug distribution inside solid tumors whose interiors are poorly vascularized. To resolve the above issues, firstly, asymmetric silica-coated UCNPs were prepared with tunable silica coverage ratio and morphology. On one hand, through stepwise …
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Impact of written drug information in patient package inserts: Acceptance and impact on benefit/risk perception
… insert (PPI), a folded sheet of paper in the drug package with a text which is supposed to be comprehensible for the general public. The PPI contains information on how the drug must be taken, on the risks of taking the drug, and a limited amount of information on whatthe drug is for. Belgium …
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Formulation of oral dosage forms by three dimensional printing
… acidic media were performed using both dye and drug (antihistamine) as actives. Deposition was performed by micro pipette into concept devices. It was concluded that printing parameters could be used to control the microstructure and release behavior. The performance of a drop-on-demand inkjet …
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Translational phosphoproteomics methods to identify biomarkers and novel therapeutic targets
… analysis of phosphoproteome in response to drug candidates can help identify biomarkers for therapeutic response as well as lend direct insights into potential adaptive resistance mechanisms. However, quantification of phosphoproteome, especially the translationally relevant low abundant …
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Study of drug delivery and cell encapsulation using biocompatible hydrogel
… are becoming an attractive means to mediate drug delivery or facilitate cell-based treatment of diseases. These particles are capable of maintaining drug stability/cell viability and providing specific drug release profiles. The selection of specific hydrogel and particle size depends on the …
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The Use of Spectral Imaging to Reveal Inorganics and Organics Identity in The Biological Samples
… the inorganics/organics molecules to understand drug activity, cellular toxicity, and distribution. Using the microscopy technique, we found for the first time that spectral imaging can provide a high temporal and spatial resolution of gold (Au) and silver (Ag) nanoparticles (NPs) in fixed, …
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Diagnosing the Increase in Homicides in Montevideo
… be at the core of the growth of homicides, with drug distribution at the retail level being probably the main force driving gang formation and wars.
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Mechanical loading impacts intramuscular drug transport : impact on local drug delivery
Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue pharmacokinetics. In muscular tissues, complex architecture that is further …
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Biosynthesis of polyhydroxyalkanoates and their medical applications
… these biomaterials have also been combined with drugs and used as drug delivery systems, thereby reducing the microbial infections while maximising tissue regeneration (Gomes et al., 2004). There are several factors that make polyhydroxyalkanoates (PHAs) excellent materials for use in TE, …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
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Elucidation of Drug Release Mechanisms in PLGA Microspheres
… and theoretically elucidate mechanisms of drug release in PLGA microspheres. We showed the effect of microsphere size and presence of an antacid on the stability and release of plasmid DNA from PLGA microspheres. We demonstrated that the use of Mg(OH)2 as a stabilizing excipient affected …
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Effervescent proliposomes for aerosol delivery to paranasal sinuses
… were found to influence liposome size and drug entrapment of the hydrophobic drug Beclometasone dipropionate (BDP). Mannitol-based formulations developed with DPPC:Chol (1:1) produced liposomes of 7.54±0.15 µm with a drug entrapment efficiency of 82.15±8.29%. Addition of the mucoadhesives …
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Examining Pharmacy Students’ Perceptions Of Clinical Faculty Mentoring Characteristics Influencing Students’ Decision To Pursue A Pharmacy Residency
<p>The field of pharmacy is changing from a drug-distribution-centered model to a patient-centered integrated model whereby pharmacists are actively involved in patient care as part of an interdisciplinary team. To address the estimated pharmacy leadership crisis in the future and to prepare …
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Unlocking value in healthcare delivery channels
… effect on supplier responsibility for tracking drugs down to the user, and ever more pressure to cut costs and justify the high cost of medicine, manufacturers are actively reshaping their role in the pharmaceutical supply chain. Our objective in this thesis project was to support our Sponsor …
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Developing & applying a miniaturized active microchip device
… have been limited due to the relatively narrow drug distribution profile they achieve. Convection enhanced delivery has demonstrated that broad distribution is key, but is limited due to uncertain spatial distribution and serious side effects. Miniaturized depot devices, implanted into the …
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