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Showing 1 to 20 of 24 for “"Drug dissolution"”.
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Probabilistic models for drug dissolution
… Direct and Inverse Monte-Carlo-based models for drug dissolution. Drug dissolution from different carriers is a complex phenomenon. Limited knowledge is available on some of the underlying constituent processes, which restricts development of mechanistic models. Monte Carlo techniques permit the …
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The kinetics of drug dissolution in polymers during hot-melt extrusion
… bioavailability for the poorly-water soluble drugs and controlled release characteristics for the water-soluble drugs. In pharmaceutical Hot-melt extrusion poorly water soluble drug particulates are mixed with water soluble polymer excipient particulates and fed in the extruder, where the …
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Development and characterization of a novel drug dissolution test method using a quartz crystal microbalance
<p>Current dissolution apparatuses require several hundred milligrams of sample per trial, measure dissolution rate indirectly via concentration sampling, and cannot maintain sink conditions throughout the duration of a test. This work describes a novel dissolution testing methodology developed …
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Interações da trancinolona com ciclodextrinas em sistemas multicomponentes
… is a relevant anti-inflammatory costicosteroid drug, used mainly by injectable suspensions due its poor water solubility. The association of triamcinolone with cyclodextrins and co-solvents (triethanolamine TEA and N-methylpirrolidone NMP) was held to solubilize the drug and explain the involved …
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… enhancement of poorly water-soluble drugs. While they both have several advantages-disadvantages, a scientific comparative assessment of their drug release performance and dissolution mechanisms at different drug doses is not available. With the goal of addressing this issue, the …
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Preparation and characterization of fast dissolving pullulan films containing griseofulvin nanoparticles for bioavailability enhancement
… of griseofulvin, a model poorly water-soluble drug, via increasing drug dissolution rate through preparation of drug nanoparticle-laden, pullulan-based strip films. The work entails (i) wet-milling griseofulvin in a stirred media mill using pullulan (polymer) along with sodium dodecyl sulfate …
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ΝΕΟΙ ΠΟΤΕΝΣΙΟΜΕΤΡΙΚΟΙ ΑΝΙΧΝΕΥΤΕΣ ΜΕ ΕΦΑΡΜΟΓΕΣ ΣΤΗ ΦΑΡΜΑΚΕΥΤΙΚΗ ΑΝΑΛΥΣΗ
… AND THE STUDY OF THE ADSORPTION OF THE SANE DRUG TO ACTIVATED CHARCOAL POTENTIOMETRICALLY. 4) THE APPLICATION OF THE CIMETIDINE AND KEMITIDINE ELECTRODES TO THE ANALYSIS OF THE DRUGS IN SERUM AND URINE AFTER EXTRACTING THEDRUGS WITH COMMERCIALLY AVAILABLE SEP-PAK CARTRIDGES. 5) THE NEWLY …
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Studium tabletovin a tablet s retardující složkou obsahující hypromelosu a sodnou sůl karmelosy.
… also contained salicylic acid as a model drug at concentration of 25 % and sodium stearyl fumarate as a lubricant at concentration of 1%. Flow properties, specifically fowability, apparent volumes and densities were evaluated at the tableting materials. During tablet compression, …
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Influence of hot melt extrusion processing parameters on the properties of a pharmaceutical formulation
… evaluated using carbamazepine as a model drug. Moisture content and gas introduced during the process will be assessed and illustrate the best method to remove them. Process parameters show a significant effect on the product quality. Polymer selection and the ratio between the polymers …
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Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
… variable oral bioavailability, and high drug resistance are the three main drawbacks which hamper etoposide activity. The central hypothesis of this work is to enhance etoposide (VP-16) solubility, dissolution, and improve its antitumor activity using emerging formulations strategies such …
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Physicochemical and tableting properties of crystallised and spray-dried phenylbutazone containing polymeric additives. Effect of polymeric additives (hydroxypropyl methylcellulose and a polyoxyethylene-polyoxypropylene glycol) on the crystalline structure, physicochemical properties and tableting behaviour of crystallised and spray-dried phenylbutazone powders
The physicochemical properties of a drug affect to a large extent its subsequent biological absorption and bioavailability profile. Considerable pharmaceutical interest is therefore directed torwards the improvement of drug dissolution characteristics of drugs with low aqueous solubility. This …
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Development and Evaluation of a Small Volume Liquid Impaction Surface (SVLIS) in the Next Generation Impactor (NGI)
… of in vitro models for studying the deposition, dissolution and absorption of orally inhaled drug formulations. Models that integrate the study of at least two of these processes would be better able to simulate conditions in vivo. This thesis describes the design and evaluation of a Small Volume …
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Developing a single dressing containing both antifungal and antibacterial drugs for treating mixed infections in diabetic foot ulcers
… of broad-spectrum antibiotic and antifungal drugs to target mixed infections in DFUs. The therapeutic calcium alginate (CA) based dressings were prepared as films and wafers by solvent casting and freeze-drying technique respectively, with ciprofloxacin (CIP) and fluconazole (FLU) as model …
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Development of novel formulations for mucosal delivery of protein based drugs
… serum albumin (BSA) and insulin (INS) as model drugs for further development. The optimised xerogels were loaded with enzyme inhibitor (EI) and permeation enhancer (PE) to enhance permeability of the buccal mucosa and backed with impervious ethylcellulose (EC) laminate to ensure unidirectional …
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Activation of Release by Hydration in Pharmaceutical Tablets Studied by Terahertz Pulsed Imaging
… step for tablet disintegration and subsequent drug dissolution. Even for tablets that do not disintegrate (e.g. sustained release tablets), hydration of the oral solid dosage form still plays a critical role in activating the drug release. In this thesis, terahertz pulsed imaging (TPI) was used …
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Modification of natural hydrophilic polymers for use in pharmaceutical formulations
… when poorly compressible and/or highly non-polar drugs need to be formulated. The influence of the lubricant magnesium stearate (MgSt) on the powder and tablet properties of chitin-Mg silicate co-precipitate was examined and compared with lubricated Avicel® 200 and Avicel-Mg silicate …
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DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS
… (CR) matrix system for poorly water-soluble drug in order to enhance its solubility and dissolution rate while maintaining the stability of the supersaturated state during and after dissolution. Two types of polymeric carriers, namely hydroxypropyl methylcellulose acetate succinate (HPMCAS) …
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Precipitation of micro/nanoparticles in enhanced high energy dissipation mixing systems
… active ingredients. Rapid development of a drug candidate is dependent on the ability to produce a desired drug substance with consistent properties, These properties include stability and purity, which are directly affected by the crystallization process and which affect, in turn, …
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Nuclear Magnetic Resonance for the Characterisation of Hot-Melt Extruded Pharmaceutical Amorphous Solid Dispersions
… suffer from poor solubility. The formulation of drug/polymer amorphous solid dispersions (ASDs) is one of the most successful strategies for improving the oral bioavailability of poorly soluble APIs. Hot-melt extrusion (HME) is one method for preparing ASDs that is growing in importance in the …
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