Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 235 for “"Drug delivery systems"”.
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Silver Nanoparticles As Drug Delivery Systems
… site. Here, we test a SNP based osteogenic drug delivery system, both in vitro and in vivo, that will provide clinicians and health care providers control of the activation stem cell differentiation leading to the formation of bone. We will evaluate the in vitro osteogenic differentiation of …
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Biodegradable polyanhydrides as drug delivery systems
… are useful biodegradable vehicles for controlled drug delivery. In aqueous media the breaking of the anhydride bonds resulting in gradually polymer fragments collapse and release drugs in a controlled manner. In this study, two new biodegradable polyanhydrides copolymers were synthesised using a …
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Liposome drug delivery systems for anticancer agents
… convertible liposomal system for anticancer drug delivery. A novel PEG-lipid, PEG<sub>2ooo</sub>-Hz-DHG, with an acid-labile hydrazone linker between the PEG<sub>2ooo</sub> head group and the lipidic DHG moiety was synthesized. PEG<sub>2000</sub>-Hz-DHG was relatively stable at normal …
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Polyurethane nanocomposites as potential drug delivery systems
… remarkable potential in the field of controlled drug delivery. There are a range of factors proposed to perturb the release mechanisms in polymer NCs, but little focus has been directed towards the understanding of interactions between the drug and NC which can also affect the drug release …
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Oscillating Aqueous Gels as Drug Delivery Systems
… gels formed by surfactant/cosurfactant/oil/water systems have been studied as potential novel controlled release drug delivery systems. They possess a unique oscillating property that was evaluated as a means of controlling drug release dependent upon intentional structural modifications of the …
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Investigating Controlled Release Pulmonary Drug Delivery Systems
The therapeutic effect of pulmonary drug delivery systems is limited by its rapid clearance from the lungs by robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved …
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Elucidating bioadhesive processes in nasal drug delivery systems
… nose, resulting in an increased opportunity for drug absorption and thus greater bioavailability.
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Colloidal microgels as (trans)dermal drug delivery systems
In this study microgels have been used as novel drug carriers (i.e. a novel controlled drug delivery system) for either dermal or transdermal delivery. The experiments conducted in this project were, firstly, to investigate the uptake and release of model compounds with different physico-chemical …
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SILOXANE-CONTAINING PHOSPHOLIPIDS AS POTENTIAL DRUG DELIVERY SYSTEMS
Drug delivery systems (DDS) have become an important focus research over the past three decades with the emergence of new therapies based on biomolecules such as peptides, DNA, enzymes etc., with the aim of improving or optimising the potency of these biomolecules. Liposomes are colloidal vesicles …
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Non-viral drug delivery systems for immune modulation
… polymer particles have diverse applications in drug delivery. The main objective of this thesis was to apply these delivery systems to modulating the immune system. We optimized particle formulations for the delivery of three novel immune modulating compounds, small inhibiting RNA, …
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Development of Multifunctional Drug Delivery Systems for Locoregional Therapy
Locoregional treatment is the specific delivery of therapeutics to their desired sites of action with minimized systemic adverse effects. In this approach, drug is administered through topical instillation, inhalation, intra-lesional or intra-arterial injection. Decades of experience in …
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Linker-based Lecithin Microemulsions as Transdermal Drug Delivery Systems
The interest in microemulsions as transdermal delivery systems have been motivated by their large surface area for mass transfer, their high solubilization capacity of hydrophobic actives, and their ability to improve skin penetration. Lecithins (mixtures of phospholipids similar to those find in …
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Water-in Water (W/W) Emulsion Drug Delivery Systems
… stability and evaluating their potential as drug delivery systems.The viscosity of the dispersed phase and continuous phase was increased with xanthan and gellan gums, respectively, to enhance the apparent stability of the emulsions. Different methods of emulsification such as an overhead …
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EXPLOITING NANOSCALE MATERIALS PROPERTIES FOR CONTROLLED DRUG DELIVERY SYSTEMS
… objective of this work was to develop a novel drug delivery system exploiting special opportunities afforded by synthesis of nanoscale materials to be applied inside the colon. It must be robust enough to cope with the adverse conditions in the gastrointestinal tract (GI) and be able to reach …
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Zirconium-based metal-organic frameworks as drug delivery systems
… a variety of designs for targeted therapeutic delivery. This thesis aims to understand and develop the Zr-based MOFs as a drug delivery system. Firstly, a Zr-based MOF, NU-1000, was examined for its ability to encapsulate and deliver a large hydrophobic drug, fulvestrant, in breast cancer …
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Development of Liposome Drug Delivery Systems for Anti-Glioma Therapy
… in generating paclitaxel-loaded liposome delivery in vitro, by employing various phospholipid compositions. Liposomes prepared using ethanol-based proliposome method successfully generated multilamellar vesicles. Three different lipid phases: SPC:Chol, HSPC:Chol or DPPC:Chol in 1:1 mole …
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Development and formulation of wax-based transdermal drug delivery systems
… formulations are promising platforms for the delivery of drugs. A unit dose topical or transdermal drug delivery system that optimises the solubility of drugs within the vehicle provides a novel dosage form for efficacious delivery that also offers a simple manufacture technique is desirable. …
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Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems
… dispersion (ASD) is a popular method to increase drug solubility and consequently poor drug bioavailability. Cellulose ω-carboxyesters were designed and synthesized specifically for ASD preparations in Edgar lab that can meet the ASD expectations such as high Tg, recrystallization prevention and …
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Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
… specific aim 1, loading hydrophobic paclitaxel drug or hydrophobic ion pairing complex(HIP) of doxorubicin molecules, and characterizing them for shape, size and polydispersity indices, (ii) conjugation of a ligand( PSMA antibody) on the surfaces of nanomicelles to ensure selectivity and …
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