Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Drug analysis"”.
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Mass spectrometry and drug analysis an introduction.
Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1981.
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A study of column switching liquid chromatography in drug analysis.
Drug analysis methods and the sample pretreatment of biological fluids are reviewed. A survey of column switching liquid chromatography techniques revealed the range of column dimensions, the frequency of prior sample pretreatment steps and small injection volumes used and the varied longevity of …
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Innovative analytical methods for Central Nervous System Drug analysis in biological fluids
… number of central nervous system (CNS) drugs have been approved and introduced on the market for the treatment of many psychiatric and neurological disorders, including psychosis, depression, Parkinson disease and epilepsy. Despite the great advancements obtained in the treatment of CNS …
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Studies of UHPLC-MS performance and application to rapid sensitive and robust drug analysis
… chromatography-mass spectrometry (LC-MS) for the analysis of basic drugs. UHPLC-MS technologies are investigated to facilitate fast, sensitive and robust analysis of drugs in biological matrices, particularly those related to doping in human sport. Mobile phase solvent, pH and temperature …
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The development of appropriate methods for drug analysis at the Forensic Chemistry Laboratory, Cape Town
… these samples test positive for the presence of drugs and other toxic substances. Because of resource constraints, pathologists submit samples at their discretion and not on a routine basis. In this study, forensic and chemical aspects were combined and used as the motivation for the development …
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Reproducibility of Retention Indices Examining Column Type
Requests for drug analysis accounted for nearly half of all requests (DNA, toxicology, latent prints, etc.) submitted to forensic laboratories in the United States (Storm et al., 2010). A study by RTI International found that laboratories are only capable of processing about 80% of their controlled …
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Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry
… or complementary matrix to blood and urine for drug analysis. Hair analysis offers a wider detection window after drug exposure than blood or urine testing and can provide a long-term history of an individual’s drug use. There are several practical applications of hair analysis for drugs …
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The determination and validation of population pharmacokinetic parameters of phenytoin in adult epileptic patients in the Western Cape using nonlinear mixed-effects modelling
… for the management of their epilepsy and no drugs known to interfere with phenytoin pharmacokinetics were taken concurrently. Clinical pharmacokinetic dosing services were initiated at 9 clinics from which patients were selected for this study. The service entailed a patient interview, a …
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The determination of drug stability by HPLC assay of degradation products.
This work evaluates the advantages in drug stability testing of following the decomposition by analysis of decomposition products. Conventional methods of drug stability testing are criticised and the limitations are shown to be largely a result of analysing for un-decomposed drug. Using simulated …
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Applications of nanopore sensing and DNA nanotechnology for the analysis of nucleic acids
… is a versatile technology for biomolecule analysis based on resistive pulse sensing. It includes biological nanopores, primarily used for long-read direct sequencing, and solid-state nanopores, which have been applied to biosensing molecules such as proteins, RNA, and DNA. While solid-state …
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Development of capillary electrophoretic-based techniques to analyze doxorubicin in tissues, cells and subcellular fractions.
Doxorubicin (DOX) is a widely used anti-cancer drug. It is hypothesized that the efficacy and toxicity of DOX is related to its distribution and metabolism. Capillary electrophoresis (CE) including its variants such as micellar electrokinetic chromatography (MEKC) is becoming a popular method in …