Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Drug activation"”.
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Nitroaromatic pro-drug activation and resistance in the African trypanosome
… These compounds are believed to act as pro-drugs that require intracellular enzymatic activation for antimicrobial activity. Here, the role of the bacterial-like nitroreductase TbNTR as a nitrodrug activating enzyme is examined through overexpression and knock-out studies in T. brucei. …
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Fundamental aspects of imaging matrix assisted laser desorption ionisation mass spectrometry.
… indirect imaging approach for the analysis of drugs in skin is described. Studies have been carried out in order to gauge how the use of a solvent in the blotting process aids the indirect imaging technique. Further experiments have been performed to assess the level of analyte migration …
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T-cell-directed bioorthogonal catalysis for localised prodrug activation in cancer therapy
… but strategies that enable selective activation of therapeutics at the tumour site remain scarce. As a result, there is a continued need for strategies that improve therapeutic efficacy, while minimising systemic toxicities. This thesis investigates the use of bioorthogonal catalysis …
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Designed Bond Cleavage Reactions for Next-Generation Therapeutics
Creating ways for tissue-specific drug activation remains a significant challenge in modern medicine. Traditional approaches to drug delivery often lack precision, leading to unwanted side effects and reduced therapeutic efficacy. This PhD thesis explores two innovative approaches to overcome these …
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Reductive metabolism of aliphatic tertiary amine n-oxides.
… amine N-oxides as antiarrhythmic agent prodrugs. Lignocaine was selected as a candidate for prodrug development, because the N-oxide is a non-active, polar derivative of lignocaine and the drug of choice for ventricular arrhythmia, a symptom associated with ischaemic episodes leading to …
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Drug Delivery Strategies Using Light Sensitive Molecules
… chemotherapy. In chemotherapy, an anti-tumoral drug is used to treat the tumor either by killing or stalling the growth of the tumor cells. In certain types of cancer, for e.g. metastatic breast cancer, the first line of therapy is often chemotherapy. But the inability of current clinically …
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Development of a gene therapy approach for the treatment of human mammary carcinoma using tissue specific retroviral vectors
… gene product activity and, possibly, specific drug activation. Use of cell type or tissue specific promoters would allow specificity of gene expression to be achieved. It is therefore important to identify and characterise tissue/tumour specific promoter/enhancer elements in and combination …