Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Drug absorption"”.
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… pharmacokinetic variability. As newly emerging drug candidates trend toward low solubility and/or permeability, biopharmaceutical properties that prolong gastrointestinal residence time, and thereby microbial contact, identifying and manipulating the microbial processes influencing drug …
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Investigating the modulation of oral drug absorption using in vitro models
Dipeptides can be absorbed into cells via the dipeptide transporter (which also transported tripeptides and dipeptide derivatives). The optimum conditions for measuring the inhibition of Gly-Pro uptake in Caco-2 cells were identified. A number of structure-activity relationships were identified. …
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The development of a computation / mathematical model to predict drug absorption across the skin
… of new therapeutic formulations in transdermal drug delivery and also for the assessment of the potential risks of environmental chemicals and agents used in cosmetics industry. There have been a large number of studies investigating skin permeability, both experimentally- and …
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Human Cytochrome P450 3A4 Over-Expressing IEC-18 and MDCK Cell Lines as an In-Vitro Model to Assess Gut Permeability and the Enzyme Metabolism
<p>Purpose. The fate of an orally administered drug is dependent on many parameters before it can reach the systemic circulation, including drug absorption and first-pass metabolism in the gut and the liver. Mammalian cells lines such as MDCK and Caco-2 are commonly employed to assess drug …
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The development of a novel in vitro model suitable for the prediction of bioavailability
In vitro studies of drug absorption processes are undertaken to assess drug candidate or formulation suitability, mechanism investigation, and ultimately for the development of predictive models. This study included each of these approaches, with the aim of developing novel in vitro methods for …
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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression of drug transporters can prove to be of utmost importance in drug delivery or drug design by targeting specific transporter proteins. …
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Elucidating bioadhesive processes in nasal drug delivery systems
… nose, resulting in an increased opportunity for drug absorption and thus greater bioavailability.
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Investigation of the absorption pathways of some poorly absorbed drugs using human intestinal (CAC0-2) cell monolayers
Absorption across the gastro-intestinal epithelium is via two pathways; the transcellular and paracellular pathway. Caco-2 cells, when cultured on polycarbonate filters, formed a confluent monolayer with many properties of differentiated intestinal epithelial cells, As a model of human …
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Engineered Liver and Intestine Platforms for Modeling Physiology and Disease
… axis, which plays a critical role in nutrient/drug absorption and metabolism. Given the diversity of roles the liver plays, there is a need for robust in vitro models capable of recapitulating changes in liver function due to cues from other organs, such as the intestine, or global physical …
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Development and Evaluation of a Small Volume Liquid Impaction Surface (SVLIS) in the Next Generation Impactor (NGI)
… for studying the deposition, dissolution and absorption of orally inhaled drug formulations. Models that integrate the study of at least two of these processes would be better able to simulate conditions in vivo. This thesis describes the design and evaluation of a Small Volume Liquid …
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Predicting aqueous solubility of pharmaceutical agents by solid dispersion prepared by solvent evaporation method
… agents is a crucial process that determines drug absorption and ultimately its bioavailability. Many of the new therapeutically beneficial compounds discovered are lipophilic requiring various solubility enhancement strategies to improve their solubility. Among these strategies, solubility …
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Development of Topical Ophthalmic In Situ Gel-Forming Estradiol Delivery System Intended for the Prevention of Age-Related Cataracts
… safety and to estimate ocular and systemic drug bioavailability of the formulation in rabbits. </p><p> An in situ gel-forming estradiol solution eye drop containing gellan gum polymer was developed as it offers a unique advantage of solution for easy handling which then undergoes a sol-gel …
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Novel carriers for oral delivery of hemophiliac factor IX
… and deliver them to the small intestine for absorption. We have successfully developed pH-responsive hydrogel networks based on poly(methacrylic acid)-grafted-poly(ethylene glycol) [P(MAA-g-EG)] as delivery vehicles for hFIX. We have focused on optimizing the drug loading and release, as well …
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IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
Drug metabolism plays an important role in drug absorption and drug elimination. Therefore, it is crucial to understand the mechanism and kinetics of drug metabolism by various drug-metabolizing enzymes (DMEs). Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of more than 60% of …
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SELECTION OF TARGETING MOIETIES DRIVING NANOPARTICLE PENETRATION THROUGH SQUAMOUS PLURISTRATIFIED EPITHELIA
Drug delivery through stratified squamous epithelia is crucial for treating various local and systemic conditions. Nevertheless, the administration through these kinds of epithelia, like the skin, the esophageal membrane, and the corneal membrane, poses significant challenges due to their complex …
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IN VITRO IN VIVO METHODS AND PHARMACOKINETIC MODELS FOR SUBCUTANEOUSLY ADMINISTERED PEPTIDE DRUG PRODUCTS
Over the last several years, injectable drugs have been a growing area for the treatment of various therapeutic conditions and they are projected to comprise an even larger proportion among the drugs that will be available in the years to come. The injectable drugs are administered by various …
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Exploring the utility of the pig model for predicting bioavailability in humans
… recognised that there is a need to reduce costly drug development delays and facilitate earlier access to market for new medicines. Within drug development, there is considerable debate on which preclinical animal model is most appropriate for assessing oral bioavailability in humans. In order to …
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Development of the Sustained Release Analgesic Formulations for Rodents and a Novel In Vitro Model for Parenteral Formulations with the Character of a Level A IVIVC
… States Pharmacopeia (USP) apparatus for in vitro drug release testing was designed mainly for oral and transdermal products. In contrast, there are no standard regulatory methods for parenteral sustained release products at present. As regards to quality control as well as formulation development …