Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Drug Trials"”.
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Pharmacoepidemiology and Drug Safety: Examining Clinical Drug Trials Via Technology
… of how IT is currently utilised in clinical trials and pharmacoepidemiology, I began working with my thesis supervisor on the protocol for the main research project. The Treatment In Morning versus Evening (TIME) study will provide additional evidence to whether morning or evening dosing of …
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Diversified use of Non-invasive Biomarkers in Study Protocol and Screen failure in Non-Alcoholic Steatohepatitis (NASH)
… in the design of study protocols for NASH drug trials and will also examine if screening approaches established using non-invasive biomarkers can reduce screen failure.
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An improved synthesis of the HDAC inhibitor trichostatin A
… since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known naturally-occurring inhibitors of histone deacetylase. Unfortunately for researchers, the …
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An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials
Traditional clinical trials have been inefficient in their methods of dose finding and dose allocation. In this paper a four-parameter logistic equation is used to model the outcome of Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the …
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Risk stratification by analysis of electrocardiographic morphology following acute coronary syndromes
… following an ACS. Data obtained from clinical drug trials indicates that our technique, called MV-DF (morphologic variability diagnostic frequencies), can significantly improve prognostication for ACS patients. Patients with MV-DF values in the highest quartile show a more than five-fold …
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The Work of Living with HIV: A Study of Binational Groups
… Of particular interest was the use of clinical drug trials by a majority of participants from both groups as either a supplemental or essential source of HIV health care. The findings of this study have implications for nurse clinicians, researchers, and educators working in community and …
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Effects of PCBs and PBDEs on response inhibition and dopaminergic signaling
… were trained on either task, they received drug challenges with the D1/D2 receptor antagonist flupenthixol (FLU), amphetamine (AMPH), and then FLU/AMPH together. It was hypothesized that PCB or PBDE exposure would result in impulsive performance on both tasks, while during the drug trials …
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Dirty Little Secrets: Prostitution and the United States Public Health Service's Sexually Transmitted Disease Inoculation Study in Guatemala
… parallel ethical questions related to foreign drug trials, globalization, and the precarious balance between the advancement of medical knowledge and the protection of individual rights. Moreover, the study's reliance on prostitutes draws our attention to the gendered nature of medical …
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Effects of α1-receptor blockade on the hemodynamic responses to exercise in young normotensives and hypertensives
… with prazosin for both groups. Regardless of drug treatment, MAP was stable for NTN while it declined after 10 min of exercise in HTN. Rectal temperatures rose above baseline after 10 min. since Q was similar between groups with placebo but not with α1- blockade, and FBF, MAP, and HR were …
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Understanding the effects of sex chromosomes and sex hormones on sex differences
… regulations that require clinical studies and drug trials to account for sex as a biological variable. This new wave of interest in sex differences is focused on three aspects: First, what factors show quantitative sex differences at the molecular and cellular levels, and how are they …
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Pattern Analysis of Response to Acute Fluoxetine Treatment in the Prediction of Relapse in Children and Adolescents
… among children and adolescents. Antidepressant drug trials aimed at addressing the problem frequently encounter problems in establishing drug efficacy due to the prevalence of placebo effects that are especially prominent in this population, and likewise, placebo responding clouds clinical …
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Variations in pollen and fungal spore air spora: an analysis of 30 years of monitoring for the clinical assessment of patients in the Western Cape
… When patients are recruited for clinical drug trials, their place of residence or work should be within the realm of the aerobiome that is being monitored. Current pollen monitoring programmes should be consulted for immunisation regimes to grass and tree pollen. These findings will be …
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Tumour chemo sensitivity assays: an investigation into the susceptibility of cells to chemotherapeutics
To evaluate and identify new candidate cancer drug targets, there is an ongoing need for a reliable, sensitive and quantitative assay that enables the analysis of larger numbers of compounds in preclinical research. This thesis has developed, and optimized a sensitive enzyme-release assay for …
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Population-based genotype-phenotype correlation to stratify incident cases of motor neurone disease in Scotland from 2015-2017
… has established a platform for recruitment into drug trials. The epidemiological data show a changing landscape of MND in Scotland with a marked increase in incidence over 25 years. This is likely attributable to ascertainment in the context of improved neurological services in Scotland. Early …
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Evaluation of Anthelmintic Properties and Toxicity of Pure Compounds Isolated from Dalea Spp (Plantae, Fabaceae)
… primary treatment; however, resistance to these drugs is emerging. Due to this resistance, finding new anthelmintic compounds active against hookworm is a priority. Previously, a pure compound isolated from <em>Dalea ornata </em>was identified as having strong anthelmintic activity when used …