Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Drug Transport"”.
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Quantifying passive drug transport across lipid membranes
… health challenges. The inexorable emergence of drug resistant pathogens, combined with a steep decline in antibacterial drug discovery, has led to a major crisis. One of the most common drug resistance mechanisms involves bacteria adapting to reduce intracellular drug accumulation. To understand …
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Modulation of drug transport by citrus fruit juices
Fruit juice-drug interactions involving drug transporters have been variously studied with citrus fruit juices. The collective data led us to hypothesize that the modulating activity of citrus fruit juices on cellular transport and metabolic pathways is dependent on the dominant flavonoid pattern …
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Using Mechanical Interventions To Enhance Drug Transport To Bone Tumors
… bone deformations that increase convective transport via interstitial fluid flow. We hypothesize that mechanical loading can increase the molecular transport of chemotherapeutic drugs to bone tumors. To test this hypothesis, a preclinical model of breast cancer metastasis to bone was used to …
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Mechanical loading impacts intramuscular drug transport : impact on local drug delivery
Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue pharmacokinetics. In muscular tissues, complex architecture that is further …
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Energetics and Structural Aspects of Cation-Coupled Drug Transport by NorM Multidrug Transporters
NorM multidrug transport proteins belong to the multiple antibiotics and toxins extrusion (MATE) family of secondary active transporters. Members of this family are present across all species including bacteria, plants and humans. In bacteria, their over-expression can lead to antibiotic …
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A foe-inspired friend: Constructing a tumor tissue-mimicking biomaterial to study intratumoral drug transport
… tumor microenvironment and its implementation on drug screening of new anticancer therapies is an active challenge that sits at the interface of biomaterials and cancer biology. As recent clinical successes of human intratumoral therapies stimulate research on intratumoral delivery, a need for an …
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Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport
Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to the low skin permeability, transdermal drug delivery is currently limited to …
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Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs
Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for studying skeletal muscle biomechanics typically use: mounting techniques that …
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Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
… candidates: levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with Pluronic® triblock copolymers (polyethylene glycol-polypropylene glycol-polyethylene glycol) should allow increased …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
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Bacteria-Enabled Autonomous Drug Delivery Systems: Development, Characterization of Intratumoral Transport and Modeling
… the efficacy of the therapeutics but also on the transport of the drug to all tumor cells in sufficient concentrations. Intratumoral drug transport is limited by characteristics of the tumor microenvironment such as elevated interstitial pressure and sparse, irregular vascularization. Moreover, …
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The synthesis of amphiphilic diblock copolymers: An investigation into the formation of micelles as a function of hydrophobic block length
… copolymers show great potential for anti-cancer drug transport due to their ability to aggregate into protective core-shell micelles. Using RAFT polymerization, copolymers containing poly(acrylic acid) and poly(methyl acrylate) blocks were made with high monomer conversion and narrow …
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Computational model of local intravascular drug delivery
Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical to examine factors that alter local biologic outcome. The central hypothesis of …
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Polymerní terapeutika pro imunoonkoterapii
… of water-soluble polymer conjugates of the model drug ZM241385. This drug was first derivatized and then connected to a polymer carrier in order to prepare a system suitable for targeted drug transport to tumor tissues. Improved pharmacokinetic parameters of the prepared polymeric systems carrying …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… that microvascular washout impedes myocardial drug transport, early angiogenic response further exacerbates drug washout and is likely responsible for late vessel regression, modulating drug PK properties to mitigate drug clearance through washout can enhance late tissue response. These results …
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A fully implantable intracochlear drug delivery device : development and characterization
… is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of sensorineural hearing loss. This versatile device is envisioned to deliver multiple therapies and control the sequence and rate of drug dosing. Such a system could …
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On the mechanisms of substrate translocation by the ABC transporter MsbA
Multidrug resistance (MDR) has been a significant problem for decades and limits the use of available chemotherapeutic drugs in treatments of bacterial infections and cancers. One of the key reasons for the development of MDR is the expression of polyspecific drug efflux pumps in cells. MsbA is an …
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Pharmacological aspects of the inhibition of mammalian respiratory complex I
… aspect of the pharmacology of complex I is drug-induced mitochondrial dysfunction, particularly its role in liver toxicity. Complex I inhibition causes an energy deficit and can lead to adverse changes in the status of the mitochondrial [NADH]/[NAD+] pool and increased reactive oxygen …
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