Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 90 for “"Drug Response"”.
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Role of Actin and its regulating proteins in drug response
Antimicrotubule drugs are used in the treatment of childhood neuroblastoma and acute lymphoblastic leukaemia (ALL). Resistance to these agents can be a major clinical problem and mechanisms mediating resistance are not fully understood. Previous studies have reported an association between the …
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Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse
… mechanisms underlying the progression and drug resistance of high-risk HB. Our recent work on HB mouse and organoid models, patient-derived xenografts (PDX) and primary patient samples revealed a significant upregulation of ribonucleotide reductase (RNR) subunit M2 (RRM2) in high-risk HB. …
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Influence of the 3D microenvironment on glioblastoma migration and drug response
… been incremental. Improvements in therapeutic response have been dismal, and GBM continues to be the deadliest tumor of the central nervous system, with patient average survival rate of 12 months. Synergistic relationships that the tumor cells establish with the brain microenvironment have been …
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MicroRNAs as biomarkers of injury and drug response in renal transplantation
… regulators, and biomarkers of disease and drug response. High- throughput approaches such as small RNA-Sequencing (sRNA-seq) have recently been widely used to identify dysregulated microRNAs in renal injury and disease. However, the interpretation of these changes is often hampered by the …
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Discovery of microenvironment drivers of cell states, plasticity and drug response
… in viral infections like COVID-19, the responses of infected and uninfected cells can impact clinical course. The recent emergence of single-cell genomic technologies like single-cell RNA sequencing (scRNA-seq) now enable us to characterize systematically and comprehensively the roles of …
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Genetic and non-genetic determinants of drug response in type 2 diabetes
… of the cases. Despite the availability of severaldrugs, considerable interindividual variation in response to medicationsresults in unnecessary treatment failure. In addition to non-genetic factors, geneticfactors are thought to contribute to such variability. </p><p class="MsoNormal" …
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The Genetics of IBD: From Susceptibility to Drug Response and Patient Outcome
… either do not respond to a given therapy or lose response to a previously effective treatment and thus require therapeutic escalation. In the first research chapter of my thesis, I describe the results of the Personalised Anti-TNF Therapy in Crohn’s disease study. Immunogenicity to anti-TNF …
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The role of the tumour microenvironment components in cancer cell behaviour and drug response
… and improved ways of thinking about anti-cancer drug design and development are needed now and in future. Recent reports demonstrate the key role played by the tumour microenvironment (TME) in tumour progression and the development of drug resistance. This study investigated the interactions …
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Evaluating Impact of Endothelial Cells on Drug Response of Lung Cancer Spheroids Using Microfluidic Chip
Drug resistance continues to be a major limitation in the clinical management of non-small cell lung cancer (NSCLC). While most of the existing research has focused on genetic mutations of tumor cells, increasing attention is being paid to the surrounding tumor microenvironment (TME) as a key …
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Time-frequency variations in cerebellar intention tremor and prediction of drug response limb loading resulted results
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1995.
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THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES
… proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung …
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MiR-10a Regulation of Drug Response and Cancer Stem Cell Populations in Non-Small Cell Lung Carcinomas
… that convert extracellular cues to intracellular responses upon activation. Overall, this signaling pathway is under tight regulation and even slight perturbations can lead to aberrant pathway activation. In NSCLC cell lines, we found that manipulation of miR-10a results in significant changes to …
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Maternal separation in the rat : long-term effects of early life events on emotionality, drug response and neurobiology
… disorders, for example, anxiety, depression and drug abuse. Furthermore, disruptions in stress hormone and neurotransmitter levels as well as structural changes in the brain have been connected to early adversities. Animal models have been developed to experimentally investigate early …
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Genome-wide cross-cancer analysis reveals the importance of bimodal microRNA in predicting patient survival and drug response
… (PI3K) pathway, and a survey of over 200 cancer drugs found that cell lines with high miR-105 and miR-767 levels responded best to drugs targeting the same pathway. To mimic high miR-105 and miR-767-expressing tumors, the two miRNA were overexpressed in A549 lung cancer cells. High miRNA …
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Development of the chick chorioallantoic membrane (CAM) model to assess tumour growth and drug response in osteosarcoma and bladder cancer
… assay's efficacy in assessing tumour growth and drug responses, with the NuOSS scaffold emerging as particularly effective for establishing tumours. Despite its sensitivity to environmental variability and the labour-intensive nature of the technique, the CAM assay offers significant advantages. …
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Using machine learning to understand the link between gene essentiality, gene expression and the chemosensitivity of cancer cells
… learning in precision medicine, particularly in drug response prediction. In this thesis, an in-depth investigation is conducted on carefully curated and integrated breast cancer focused datasets from the GDSC (Genomics of Drug Sensitivity in Cancer) and Achilles (CRISPR derived) project …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
… analytic methods for predicting therapeutic response to drug in Korea asthmatics and tried to develop a clinical model to predict the drug response to asthma drug. BACKGROUND: Long acting β2-agonists (LABA) is the most powerful bronchodilator and inhaled corticosteroid (ICS) was the most …
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Application of foundation models for molecular representation in cancer drug discovery and precision oncology
Drug discovery is a resource-intensive and time-consuming process, often requiring decades of effort and substantial financial investment, with a high risk of failure. Despite advances in high-throughput screening technologies, the size of chemical space presents a significant challenge: it is not …
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