Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 127 for “"Drug Loading"”.
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Solubility enhancement of poorly water soluble drugs using liposome technology
… could control the encapsulation of lipophilic drugs and investigate the influence of the physical properties of poorly water-soluble drugs on bilayer loading. Initial work investigated on the solubilisation of ibuprofen, a model insoluble drug. Drug loading was assessed using HPLC and UV …
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Trigger-responsive nanomedicines through controlled chemistry
… Ph.D. thesis is to develop trigger-responsive prodrug platform to address the nanoparticle (NP) formulation issue in cancer therapeutics. By designing a trigger-responsive camptothecin (CPT) prodrug structure, it was demonstrated for the first time that a small molecule prodrug could be …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local delivery of a hydrophobic …
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Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery
Amorphous solid dispersions of polysaccharide-drug nanoparticles were produced by a rapid precipitation process known as flash nanoprecipitation and the formulation process and properties of nanoparticles were investigated. In this thesis, several novel cellulose derivatives and a pullulan …
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Formulation and dissolution of polymer strip films for the delivery of poorly water-soluble drug nanoparticles
… have focused on incorporation of water-soluble drugs. The objective of this dissertation is to explore the robustness and versatility of the strip film platform for delivery of poorly water-soluble drug nanoparticles to ultimately develop a predictive model for drug release from such films. The …
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Formulation of novel buccal mucosal drug delivery systems for nicotine replacement therapy (NRT)
… the buccal mucosa route. Composite blank (BK), drug loaded (DL) HPMC-SA films (optimized with 2% w/v plasticizer) and wafers (optimized by freeze drying; annealing) were formulated. Further, nicotine stabilisation using MAS (magnesium aluminium silicate) in optimised composite HPMC-SA films and …
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Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
… the effect of macromolecule molecular weight on drug loading and entrapment efficiency. In order to ensure sustained and prolonged release, nanoparticles were suspended in thermosensitive gel which acted as a secondary barrier. The second approach was combining the benefit of two technologies …
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Design, Synthesis and Characterization of Porous Silica Nanoparticles and Application in Intracellular Drug Delivery
Nanoparticle mediated drug delivery approaches provide potential opportunities for targeting and killing of intracellular bacteria. Among them, the porous silica nanoparticles deserve special attention due to their multifunctional properties such as high drug loading, controlled drug release and …
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Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System
… on Mesoporous Silica Nanoparticles (MSN) for drug/drug combination therapies. The objective of my dissertation was to optimize surface functionality, particle shape and methods of colloidal stabilization of mesoporous silica by PEG for delivery of drug/drug combinations. This was achieved by …
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DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS
… (CR) matrix system for poorly water-soluble drug in order to enhance its solubility and dissolution rate while maintaining the stability of the supersaturated state during and after dissolution. Two types of polymeric carriers, namely hydroxypropyl methylcellulose acetate succinate (HPMCAS) …
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Effect of ethyl oleate and oleic anhydride on metronidazole release from poly(ortho esters) films
… esters) films with adjuvants demonstrated slower drug release for all concentrations of ethyl oleate studied and for 0.375% and 0.75% w/w of oleic anhydride. The effects of drug loading (5, 7.5 and 10% w/w) and film thickness (150 to 400 !J.m) were also studied in the presence of 0.75 %w/w of …
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Design and Development of Biocompatible MOFS and Silica-Based Nanocarriers with Controlled Pharmacokinetics for Drug Delivery Applications
… and silica-based materials as nanocarriers for drug delivery applications, owing to their exceptionally high surface area and highly structured porous network. The overall goal of this research was to optimize the pharmacokinetic behavior of several highly porous biocompatible drug carriers that …
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Synergistically active curcumin resveratrol solid lipid nanoparticles for treatment of melanoma
… solid lipid nanoparticles were introduced as a drug carrier to enhance the skin penetration of the aforementioned polyphenols and exploit their anti-cancer activity. Small, negatively charged curcumin and resveratrol loaded SLNs (Cur-Res SLNs) with a mean diameter of 180.17 ± 7.69 nm were …
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Development of Multifunctional Drug Delivery Systems for Locoregional Therapy
… systemic adverse effects. In this approach, drug is administered through topical instillation, inhalation, intra-lesional or intra-arterial injection. Decades of experience in locoregional treatment have delivered meaningful benefits to patients with localized diseases (e.g., osteoarthritis, …
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The effect of precipitation techniques on bioadhesive microparticle characteristics
… hydrochloride (MH) were investigated as model drugs using the optimised processes. The resultant VH:HPMC (1:1) microparticles achieved a maximum drug loading of only 8.7%, and precipitation of MH:HPMC microparticles in IPA achieved a similar loading. However, MH:HPMC microparticles with a drug …
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Engineered Polydopamine Nanocarriers for Biomedical Applications
… in the field of nanomedicine and the design of drug nanocarriers, several critical challenges persist. These include limited cargo delivery due to uncontrolled drug release, off-target toxicity, premature aggregation, and rapid clearance of nano-formulations. Among the nanomaterials explored, …
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Mechanistic study of nanoemulsion absorption and its application for permeation enhancement
… the oil can incorporate poorly water soluble drugs to form a liquid dosage form. The enhancement of bioavailability with a use of nanoemulsion has often been reported empirically and speculated to be a result of the enhanced dissolution due to a larger surface area, however, the mechanism of …
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Polymer drug dispersions: understanding structure and dynamics
… pharmaceutical development of APIs. Amorphous drugs are attractive due to increased dissolution; however can unpredictably revert to the thermodynamically stable crystalline form. Accurate prediction of molecular level physical stability would be advantageous. Research surrounding stability …
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Study of porous magnetic nanocomposites for bio-catalysis and drug delivery
… materials. The targeted stimuli triggered drug release restrict the toxic drugs to the tumour site, thereby reducing the effects of “free drug” on healthy tissues. One of the most versatile and safe materials used in medicine are iron oxide nanoparticles. This project describes the …
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Aerosolizable Drug-Loaded SPIONs for Treatment and Diagnosis of Pulmonary Tuberculosis
… infectious diseases, with the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains presenting significant challenges to current therapeutic strategies. Existing treatment regimens are prolonged, systemically toxic, and poorly targeted, often resulting in poor …
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