Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Drug Exposure"”.
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Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure
… was to identify the effects of chemotherapeutic drug exposure on the mechanical properties and cytoskeletal composition of drug sensitive and drug resistant malignant melanoma cells. To achieve this, a combination of Multiple particle tracking microrheology (MPTM), quantitative RT-PCR and Western …
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Advancing tuberculosis treatment through pharmacometric modeling of drug exposure and biomarkers
… utilized pharmacometric modelling and data from drug-susceptible pulmonary tuberculosis patients as well as in vitro data to characterise the pharmacokinetics (PK) and pharmacodynamics (PD) of first-line anti-tuberculosis drugs and tuberculosis biomarkers. A key focus in these analyses was to …
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Post-mortem toxicological analysis of hair in violent fatalities: an investigation into long-term drug exposure
… an association between violent mortalities and drug use. Furthermore, long-term drug use has been shown to alter behaviour that may lead to violence. Hence, this study aimed to investigate the effect of long-term drug use on violence-related mortalities. Due to the drug retention properties of …
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The nature, extent, and range of evidence of the premature constriction or closure of the ductus arteriosus in utero unrelated to known non-steroidal-anti-inflammatory drug exposure: a scoping review
… the fetal lungs. Non-steroidal anti-inflammatory drug (NSAID) use in late pregnancy can cause premature constriction or closure of the ductus arteriosus (PCDA), though cases also occur without NSAID exposure. Understanding non-NSAID-related PCDA (NNPCDA) is important for prenatal care. Objective: …
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Identification and characterization of gene and microRNA networks associated with cancer survival and drug abuse
… of the transcriptome in diseases like cancer and drug abuse can offer insights into preventive and therapeutical remedies, as well as targets for future basic and applied research. The identification of reliable transcriptome biomarkers requires the simultaneous consideration of regulatory and …
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Using Advanced In Vitro Models to Investigate the Adverse Effects of Methotrexate on the Developing Epigenome
Drug exposure during pregnancy has the potential to impact three generations in one: the mother (F0), the embryo (F1), and the future grandchildren in the form of developing gametes (F2). Recently, the effect of pharmaceutical drugs on the epigenome has come to light with more novel drugs being …
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Genetic Polymorphisms and the Treatment Outcome in Standard-Risk Pediatric Acute Lymphoblastic Leukemia
… Survival (OS) rate < 5%. Modern-day, multi-drug chemotherapy is associated with an overall survival rate over 80%. Standard-risk ALL comprises the majority of ALL with an overall survival approaching 90%. Despite this success, children who relapse from this disease accounts for the majority …
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Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs
… the first 2 months of treatment. The effect of drug exposure on patient outcomes was investigated. To determine the adequacy of ofloxacin drug exposure, the probability of attaining the required area-under-the-curve to minimum inhibitory concentration ratio (AUC/MIC) of ofloxacin was determined …
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Repeated amphetamine exposure and the enduring consequences on behavioral and neural plasticity
… unique amongst the category of psychoactive drugs, as they are both prescribed for therapeutic purposes at an alarmingly increasing rate and abused illicitly on account of their potential pleasurable effects (World Drug Report, 2012). In adult subjects, chronic AMPH use is associated with …
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She Ain No Crack Ho', She's Her Baby's Mama: Counternarratives of Drug Addiction, Parent -Child Interactions, and Academic Achievement From African American Mothers
… is to enhance awareness about prenatal drug use, drug addiction, parent-child interactions, and academic achievement from the African American mothers' perspectives. Black feminist thought, critical race feminism, and resilience were used as theoretical frameworks for this study. Five …
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In vitro metabolism studies to inform physiologically-based pharmacokinetic modelling of mefloquine, ritonavir and proguanil
Clinically observed variability in drug exposure has various negative implications, ranging from an increased possibility of adverse drug reactions to treatment failure. A key contributor to this variability is the contribution of drug metabolism, substantially mediated by the cytochrome P450 (CYP) …
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Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment
… currently recommended weight-adjusted doses for drug-susceptible and -resistant tuberculosis. Concentration-time data from the RAFA study were used to characterise the pharmacokinetics of the four drugs of the fixed dose combination (FDC) therapy including desacetyl-rifampicin, and …
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Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry
… or complementary matrix to blood and urine for drug analysis. Hair analysis offers a wider detection window after drug exposure than blood or urine testing and can provide a long-term history of an individual’s drug use. There are several practical applications of hair analysis for drugs …
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DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… the reinforcing effects of many commonly abused drugs. The ventral tegmental area (VTA), a central hub of this circuitry, is well known for its robust dopaminergic projections to forebrain regions and their crucial roles in modulating reward, aversion, motivation and cognition. However, VTA GABA …
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Full-Gestational Exposure to Nicotine and Ethanol Results in Long-Term Dysregulation in the Ventral Tegmental Area
<p>Nicotine is considered a gateway drug for other drugs of abuse. The majority of smokers that begin smoking in adolescence, continue into adulthood. Multiple factors have been linked with smoking initiation, including maternal smoking. Drug exposure during pregnancy has long been suspected to …
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Sex differences in PFC-related behavior after amphetamine exposure and across adolescent development
… and risk taking. Experimentation with drug use during this period can have especially harmful consequences, however, as adolescent-onset substance use is more likely to lead to dependence. Brain regions within the mesocorticolimbic circuit are involved in the control of reward behavior …
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An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram
… protein expression, and not on the effects that drugs have on fetal brain protein complement. Klose and co-workers (1977) did an early study using two-dimensional gel electrophoresis to determine the effects of various teratogens on whole embryos. No protein changes were found and that line of …
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Computational model of local intravascular drug delivery
Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical to examine factors that alter local biologic outcome. The central hypothesis of …
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