Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Drug Drug Interaction"”.
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Evaluation of drug-drug interaction in the EHR data
Drug–drug interactions (DDIs) caused by co-prescriptions can alter the effectiveness of treatment or occurrence of adverse drug events (ADEs). Also, it in itself could be life-threatening to patients. An electronic alert for DDI is one of the most successful components of electronic medical record …
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CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction
… metabolite of sarpogrelate) on CYP isoforms or drug–drug interactions. Using a cocktail assay, the effects of sarpogrelate and M-1 on nine CYP isoforms were measured by specific marker reactions in human liver microsomes. Nine healthy male subjects genotyped for CYP2D6*1/*1 or *1/*2 were …
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A Bayesian Approach to Dose-Response Assessment and Drug-Drug Interaction Analysis: Application to In Vitro Studies
… reduction in toxicity and minimizing or delaying drug resistance. Dose-response assessment and drug-drug interaction analysis play an important part in the drug discovery process, however analysis are often poorly done. This dissertation is an effort to notably improve dose-response assessment and …
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PharMeBINet: a general-Purpose approach for the integration of heterogeneous biomedical data Sources and its application to drug-drug interaction prediction
… quality are used for multiple tasks, like drug repurposing, or the prediction of drug-target interactions, drug-drug interactions, or side effects for polypharmacy.<br /><br /> This thesis analyzes and compares existing KGs regarding their adherence to defined essential features for KGs. A …
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
… Induction of CYPs contributes to adverse drug-drug interactions. Non-toxic, PXR-specific antagonists will be valuable in attenuating the adverse drug-drug interaction which is the cause of many treatment failures in clinic. However, few hPXR antagonists were reported particularly the …
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Medication concepts, records, and lists in electronic medical record systems
… as duplication checking, allergy checking, and drug-drug interaction alerts. Clever modeling of medication records makes it easy to provide a history of any medication the patient is on and to generate the patient's medication list for any arbitrary point in time. Medication lists that …
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Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations
… those with co-morbidities requiring additional drug treatments, and those with drug-resistant strains. This leaves many unanswered questions surrounding the management of TB, HIV, and TB/HIV in these vulnerable subpopulations. In this thesis, we utilise population pharmacokinetics and …
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Multimodal AI for Hospital Readmission Prediction Among Older Adults
… based on association rule mining, a rule-based drug-drug interaction (DDI) detection method identifies potential DDIs, offering additional insights into medication safety. And third, to better process unstructured clinical text, an enhanced ClinicalBERT model, trained on MIMIC-IV discharge …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… often challenging because of the potential for drug-drug interactions. Dolutegravir-based regimens are now the preferred first-line option for the management of HIV. Therefore, many African countries have transitioned most PLWH from efavirenz- to dolutegravir-based regimens. A fixed-dose …
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NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein
… protein. These studies also determined if the drug diclofenac, a non-steroidal antiinflammatory (NSAID) that is commonly administered in conjunction with opioids during peripheral inflammatory pain (PIP), altered or modulated P-gp functional expression providing evidence of a drug-drug …
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Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions
… will ensure safe and effective use of these drugs and hence enhance the clinical outcome. The thesis starts with an introductory chapter which comprises a comprehensive literature review on gastroparesis and the available pharmacological treatment options. The chapter also emphasizes the …
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Bayesian Semi-Mechanistic Dose-Finding Designs For Phase I Oncology Trials
… and efficient in evaluating an experimental drug. In oncology, despite the great advances in novel dose-finding designs, the high failure rates of clinical cancer drug development from phase I to III trials call for further improvements on novel designs, in addition to the need to promote and …
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Pharmacokinetics of neostigmine and pyridostigmine in man.
… selective ion-pair extraction of the unchanged drugs and their metabolites into dichloromethane and dichloromethane-acetone mixture respectively. Quantitation is possible down to 3 ng/ml for parent drugs and 50 ng/ml for the metabolites. The present work also described a modified procedure to …
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PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy
… (Mtb) is the causative agent of TB. The interaction between Mtb and the immune system leads to development of diverse environmental niches and physiology within the lung of the TB patients. Mtb is thought to adapt and thrive in such an environment by transforming to different phenotypic …
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Population pharmacokinetic modelling to address the gaps in knowledge of commonly used HIV and TB drugs in children
… and antiretroviral therapies(ART) may lead to drug-drug interactions potentially needing to be addressed with the adjustment of doses. This thesis assessed the pharmacokinetics of abacavir and ethambutol and evaluated the influence of covariates such as age and concomitant medication on the PK …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… and mortality worldwide. Lifestyle changes and drugs (e.g. statins) are mainly advised by practitioners to manage cholesterol; however, safer alternatives such as natural products might be considered for mild to moderate hypercholesterolemia or in combination with statins in more severe …
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In vitro metabolism studies to inform physiologically-based pharmacokinetic modelling of mefloquine, ritonavir and proguanil
Clinically observed variability in drug exposure has various negative implications, ranging from an increased possibility of adverse drug reactions to treatment failure. A key contributor to this variability is the contribution of drug metabolism, substantially mediated by the cytochrome P450 (CYP) …
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Causal Inference Methods for Estimation of Survival and General Health Status Measures of Alzheimer’s Disease Patients
… most prevalent classes of Alzheimer’s disease drugs, Donepezil and Memantine, and their combined use on Survival and General Health Status Measures of Alzheimer's disease patients for the first five years after initial diagnosis. We carried out a thorough causal inference study using doubly …
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Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates
… of their inhibitors. Multiple clinically used drugs and dietary chemicals have been reported to inhibit these transporters and potentially increase the exposure of concomitantly administered BCRP and/or PGP substrates, which might be desirable (to increase efficacy of the substrate drug) as …
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Cerebral blood flow in the non-human primate : an in vivo model and drug interventions
… psychiatric disorders. Several cerebrovasoactive drugs have found application in the clinical setting of cerebrovascular diseases such as migraine and dementia. Due to the similarities between humans and non-human primates with respect to their brains, both structurally and behaviourally, numerous …
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