Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Drug Diffusion"”.
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Design of novel drug delivery system and optimal dosage regimens
Three representative drug delivery systems were analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion …
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Multiphysics computational modeling of implantable actuable devices for local epicardial therapy delivery
… have the potential to improve the efficiency of drug delivery by enabling the capability of giving multiple dose of therapies with only one implantation surgery and reducing the foreign body responses through mechanical oscillation. In this thesis, we used different computational models …
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Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers
… of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage of avoiding first-pass …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) …
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QSAR modeling of chemical penetration enhancers using novel replacement algorithms
… limited because of the resistance of the skin to drug diffusion. Only potent drugs, with molecular weight less than 500 Da, are suitable to cross the skin barrier. Chemical Penetration Enhancers (CPEs) are used to promote the absorption of solutes across the dermal layers. In this investigation, a …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local delivery of a hydrophobic …
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Analysis of anti-cancer drug penetration through multicell layers in vitro. The development and evaluation of an in vitro model for assessing the impact of convective fluid flow on drug penetration through avascular cancer tissues.
… (IFP) in tumours is recognized as a barrier to drug delivery resulting in reduced efficacy. High IFP impedes the normal process of convective fluid flow (CFF) from blood vessels into the interstitium. The aim of this study was to develop an in vitro model that could be used to measure CFF and to …
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Characterization of biological hydrogel barriers
… easily, the treatment of such infections by drugs had been found to be quite inefficient due to the structure of the biofilm itself and formidable mucus barrier. Mucus is a hydrogel which protects the gastrointestinal, genitor-urinal and respiratory tracts from pathogens and external …
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Cavitation monitoring and spatial mapping for pulsed high-intensity focused ultrasound enhanced drug delivery
… the tissue at the focus. Ultrasound-enhanced drug delivery is an active and promising area of research. Enhanced drug diffusion and vascular permeability following HIFU is largely attributed to mechanical tissue disruption caused by ultrasound-induced bubble activity- cavitation. Although …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… products. For orally administered small-molecule drugs, in vitro testing has been extensively studied to establish a quantitative relationship between the dissolution data and plasma drug concentration-time profiles (in vitro-in vivo correlation (IVIVC)). However, the applicability of IVIVC models …
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Developing methods of selective, location-specific drug delivery in the gastrointestinal tract
Oral drug delivery remains the most commonly used method of drug administration, due to greater patient adherence to the treatment. However, drug efficacy when delivered orally remains suboptimal due to the presence of formidable barriers to drug diffusion in the gastrointestinal (GI) tract and …
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… by applying changes in processing temperature, drug/lipid ratio and composition of the formulation processed by HME and subsequent compression into tablets were investigated. The characterization using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) exhibited Df-Na …
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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets
… release profile for a sparingly soluble drug and it was difficult to formulate a highly water soluble drug by using CA as the retarding agent. Some studies concluded that CA is very sensitive to the solubility of the drug and it is not suitable for retarding the release for highly water …
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Controlled Release of Insulin and Modified Insulin from a Novel Injectable Biodegradable Gel
… injection. <br />A biodegradable injectable drug delivery gel was prepared by dissolving a <br />biodegradable polymer, polylactic-co-glycolic acid (PLGA), in biocompatible <br />plasticizer(s), triethyl citrate (TEC) and/or acetyl triethyl citrate (ATEC). Insulin was <br />then loaded into …
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Chemical and physical methods of enhancing the percutaneous absorption of antimicrobial agents
… epidennis was investigated using Franz-type diffusion cells. Saturated solutions of CHX were used as donor and the variable studied was vehicle pH. Permeation rate was increased with increasing vehicle pH. The pH effect was not related to the level of ionisation of the drug. The effect of …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… added in different proportions to further modify drug release. The diclofenac sodium mini-matrices (4.5 mm in diameter) were produced by the wet granulation method. The release profiles from several encapsulated minimatrices in phosphate buffer solution (pH 7.0) showed that xanthan, karaya and …
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Study of drug delivery and cell encapsulation using biocompatible hydrogel
… are becoming an attractive means to mediate drug delivery or facilitate cell-based treatment of diseases. These particles are capable of maintaining drug stability/cell viability and providing specific drug release profiles. The selection of specific hydrogel and particle size depends on the …
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Mucoadhesive buccal tablets for the delivery of nicotine and Delta9-tetrahydrocannabinol.
… anomalous transport mechanism dependent on both drug diffusion and polymer relaxation. Investigation of these controlled release layers indicated that both hydrogen bonding and polymer entanglement with the mucus layer was responsible for adhesion of the formulations to animal buccal mucosa. …
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Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
… to decrease normal tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host of nanoparticles (from micelles and dendrimers to liposomes and lipidic nanoparticles) have been developed and tested for passive accumulation into …
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Multifaceted computational modelling in pharmaceutical research and development
Drug development is a multi-step process and takes around 12 to 15 years for a new drug to get approved. In the current scenario, to accelerate the drug development process and to reduce the time frame, most pharmaceutical companies have in-house developed workflows comprised of a hybrid use of …