Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"Drug Carriers"”.
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RGD based peptide amphiphiles as drug carriers for cancer targeting
… approaches for active targeting of anticancer drugs to cancer cells. Over expression of integrin receptors is a physiological manifestation in several cancers and is associated with cancer progression and metastasis, which makes it an attractive target for cancer chemotherapy. The peptide …
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Multifunctional Chemical Cross-linkers for Drug Carriers and Molecular Probes
… established modality for biomedical imaging and drug delivery. Broadly, bioconjugation is the use of a chemical cross-linker to covalently attach non-natural reporters, chemical handles, drug cargo, or targeting ligands to biologics to augment their innate properties and functions. Many …
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NANO-PARTICULATE DRUG CARRIERS FOR EFFECTIVE TARGETING AND DRUG DELIVERY TO BLADDER TUMORS
… limited efficacy due to lack of specificity of drugs/drug carriers for the tumors and the short residence time of the instilled agent in the bladder due to urine voiding. To address these challenges, albumin-based carriers in two forms i.e., native albumin chains (~16nm) and albumin …
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Production and activation of shear-responsive drug carriers for treating obstructed blood vessels: a coupled CFD-DEM approach
L'abstract è presente nell'allegato / the abstract is in the attachment
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Design, Synthesis, and Characterization of Triazaadamantane Based Monomers and Dendrimers
… macromolecules may find broad application as drug carriers and for the encapsulation and release of other substances, similar to the Trojan horse strategy. Their ability to act as proton sponges makes them particularly interesting with regards to their potential as artificial gene delivery …
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Preparation of nanovehicles for targeted drug delivery
… research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective and enhanced absorption. This work …
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Synthesis of Polysaccharide-based Biomaterials for Drug Delivery
… Conjugating a polysaccharide to a protein drug via a covalent bond may improve its medical properties including solubility, stability, immunogenicity, circulation time, and targeting ability. Regioselectivity of conjugation is still challenging. We developed a strategy for regioselective …
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Towards designing de novo (1--->4)-linked polysaccharides
… from biodegradable materials to pharmaceutical drug carriers. Small functional groups, such as hydroxyl, amine, N-acetylamide and methoxy are commonly employed for creating de novo saccharides with enhanced functionality. The physiochemical properties of carbohydrates are governed by their …
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Investigating G-protein coupled receptors as novel biomarkers for diagnosis, prognosis, and targeted therapy in ovarian cancer
… as a diagnostic tool. In a second step targeted drug carriers could be selected depending on GPCR expression profiles leading to personalised treatment. In summary, this work highlights the theranostic potential of GPCRs, which could lead to a translational framework, combining diagnostics and …
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Probabilistic models for drug dissolution
… Direct and Inverse Monte-Carlo-based models for drug dissolution. Drug dissolution from different carriers is a complex phenomenon. Limited knowledge is available on some of the underlying constituent processes, which restricts development of mechanistic models. Monte Carlo techniques permit the …
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The characterisation of a fenoprofen prodrug
The term "prodrug" refers to a pharmacologically inactive compound that is converted to an active drug by a metabolic biotransformation. A nonenzymatic process, such as hydrolysis, can activate a prodrug via several routes. Prodrugs are mostly used to improve a drug's physical and chemical …
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Assembly, characterization and evaluation of a 3rd generation nanoparticle based drug carrier for metastatic breast cancer treatment
… of the patients. Low aqueous solubility, multi-drug resistance, degradation of drug, limited intra-tumor diffusion and etc. are other limitations of conventional chemotherapies and endocrine therapies. Nanoparticle based drug carriers were extensively studied for therapeutic drug delivery. Many …
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Synthesis and Properties of ordered Mesoporous SiO2-CaO Bioactive glasses
… the bioactivities between these two glasses. As drug carriers, antibiotic gentamicin was incorporated into the ordered mesoporous bioactive glasses. The drug release profiles were monitored and the effects of drug loading on bioactivities were studied. In order to optimize the drug release …
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Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy
… (pDNA, siRNA) and chemotherapeutic (doxorubicin) drugs. We proved that these microbubbles can selectively deliver their genetic or chemotherapeutic drugs to melanoma cells upon ultrasound exposure. We also showed that the activity of currently available drug carriers (pDNA or siRNA lipoplexes and …
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Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies
'Smart' targeted drug carriers have long been sought after in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited to surgery, radiation therapy, traditional chemotherapy, and EGF receptor …
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DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… systems are often limited by their inadequate drug loading and release properties. This study reports the integration of oil into PLGA to form the prototype of a hybrid drug carrier PONC. Our primary goal is to confer the key strength of lipid-based drug carriers, i.e. efficient encapsulation …
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Ionic Copolymer-Magnetite Complexes for Magnetic Resonance Imaging and Drug Delivery
… of magnetite-ionic copolymer complexes as nanocarriers for drug delivery and magnetic resonance imaging. The polymers included phosphonate and carboxylate-containing graft and block copolymers. Oleic-acid coated magnetite nanoparticles (8-nm and 16-nm diameters) were investigated. Cisplatin and …
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Modeling the reaction mechanism of membrane penetration by striated amphiphitic gold nanoparticles
The desire to desire targeted drug delivery devices capable of releasing therapeutic payloads within the cytosol of cells has led to research on nanoparticles as suitable drug carriers. Recently, it was shown that gold nanoparticles coated in striped, alternating layers of hydrophobic and …
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Unsteady blood flow in the stenosed artery subjected to magnetic field and injected nanoparticles
… the augmentation of heat transfer due to drug carriers such as nanoparticles (Fe3O4, TiO2, Cu) was modelled. In the first problem, the non-dimensional equation was solved by combining both perturbation and power series methods. However, for the second problem, only the perturbation method …
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Development of a physiologically accurate 3D blood-brain barrier hydrogel model
… degradation, and potentially curing diseases, drug delivery experiments have been performed on the brain. However, since the drug carriers tested often may be perceived as toxins to the brain due to their large size or composition, researchers have leaned towards making in vitro 3D hydrogel …
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