Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Drug Abuse and Addiction"”.
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Effects of physical exercise and exercise-induced adult hippocampal neurogenesis on conditioned place preference for cocaine in mice
Treatments for drug abuse and addiction remain largely ineffective. Recent studies in both the human and rodent literature suggest that exercise-based interventions for drug addiction have positive outcomes. Exercise has many effects in the brain. The mechanism by which exercise achieves positive …
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5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants
Drug abuse and addiction are considered to be a result, at least in part, of the rewarding effects produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the …
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Behavioural and cellular basis of the vulnerability to develop compulsive heroin seeking habits
Addiction is a chronic relapsing disorder for which there is no effective treatment. This may reflect our lack of understanding of the psychological and neural mechanisms that support the transition, in vulnerable individuals, from recreational drug use to compulsive drug seeking habits. Over the …
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DESIGN, SYNTHESES, AND BIOLOGICAL EVALUATION OF 14-N-SUBSTITUTED NALTREXONE DERIVATIVES AS OPIOID RECEPTOR LIGANDS
… of the poppy flower, has been used for medicinal and euphoric purposes since ancient times. Morphine, the main active ingredient of opium, and other clinically useful opioid analgesics all mediate their effects through activating the mu opioid receptor. Studies involving the mu opioid receptor …
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Substance use in adolescents and young adults: Interactions of drugs of abuse and the role of parents and peers in early onset of substance use
… substances is a major contributor to disability and mortality worldwide. The use of tobacco, alcohol, and illegal drugs in adolescence and young adulthood are well-known risk factors for subsequent substance-related harms. A better understanding of adolescent and young adult substance use …
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Use and misuse of sedative drugs and related substances - Findings in the general population and in individuals with opioid dependence
… are efficient in the treatment of anxiety and sleeping disorders, but are associated with a risk of misuse and dependence, as well as an increased risk of accidents, injuries and overdoses, both in the general population and especially in individuals with other substance misuse. The present …