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Showing 1 to 1 of 1 for “"Drpitor1a"”.
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… suppress NSCLC and PAH phenotypes in vitro, and Drpitor1a, previously shown to reduce NSCLC hyperproliferation in vitro and ex vivo, can prevent PAH progression in vivo. Methods & Results: Only Drpitor1a was found to inhibit DRP1's GTPase activity in inorganic phosphate assays. While Compound 6 …