Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Drosophila genetics"”.
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Investigation of miRNAs Expression in a Citron-Kinase Mutant Model of Microcephaly
… microcephaly-like phenotype. Evidence from drosophila genetics has further established a genetic link between Cit-K and a protein Argonaut 1 (AGO1), which is required for proper functioning of the miRNA machinery (2). Experiments characterizing the role of miRNAs in the developing cortex …
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Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
… of the Semaphorin receptor Plexin. Combining Drosophila genetics with in vitro biochemical assays, my work revealed that Mical regulates actin organization both in vivo and in vitro and is a novel actin disassembly factor. These results provide a new basis for understanding how extracellular …
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Traumatic Brain Injury As An Environmental Risk Factor For Neurodegeneration: Elucidating Causal Mechanisms With Drosophila
… lab developed a new model of closed-head TBI in Drosophila, termed dTBI. The device used to inflict dTBI employs a piezoelectric actuator to briefly and rapidly compress the fly head against the metal plates of a Heisenberg fly collar. The piezoelectric is supplied with an amplified voltage pulse …
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Genetic and molecular analysis of <em>drop out</em>, the single homolog of the vertebrate MAST kinases in <em>Drosophila melanogaster</em>
… is a specialised form of cytokinesis in Drosophila melanogaster. Cellularisation occurs after the first 13 syncytial cell cycles of the embryo and involves targeted insertion of membrane to form the blastoderm, which represents a polarised epithelium made out of about 6000 cells. The …
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Transcriptional control of somatosensory neuron diversification in Drosophila
… the multidendritic (md) sensory neurons of the Drosophila melanogaster peripheral nervous system to identify genetic and molecular programs that coordinate dendrite and axonal morphogenesis in individual sensory neurons. The homeodomain transcription factor Cut is expressed in neurons with …
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Interaction between DVAP, the orthologue of human VAPB, and Drosophila Sac1
… B (hVAPB) gene cause ALS8. Interestingly, the Drosophila VAPB (DVAP) is required at the Drosophila larval neuromuscular junction (NMJ), to control bouton morphology. In Pennetta’s lab Drosophila Sac1, a phosphoinositide-4- phosphate (PI4P) phosphatase, was identified during a genome-wide yeast …
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Characterisation of Mitochondrial Dynamics and Mitochondrial DNA Inheritance in Drosophila melanogaster
… of diseases. During spermatogenesis in <i>Drosophila melanogaster</i>, the organisation of mitochondrial networks is altered during each stage of development. This thesis is focused on a novel mitochondrial structure, termed the mitoball, which occurs in the premeiotic spermatocytes in the …
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Safeguarding the mitochondrial genome: identifying components of the mtDNA repair machinery
… mechanisms across diverse species, including Drosophila melanogaster, humans, and corals, aiming to uncover the molecular processes underlying mitochondrial genome maintenance. The project initially utilised a candidate-driven approach, focusing on REC and its interacting partners. REC, the …