Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Drosophila embryogenesis"”.
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Characterising functions of long non-coding RNAs in Drosophila embryogenesis
… the impact of lncRNAs loss of function during embryogenesis of Drosophila melanogaster. I chose this model organism for its well documented developmental stages and the plethora of established tools available to facilitate genetic studies. Twenty-two lncRNA candidates were chosen based on their …
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Feedback Regulation of Wnt Signaling by Naked Cuticle (Nkd) During Drosophila Embryogenesis
… defects, cancer, osteoporosis, and diabetes. In Drosophila, the naked cuticle (nkd) gene antagonizes the Wnt/beta -catenin signaling in every segment of the embryo. Nkd is a modular, evolutionarily conserved protein that uses an EF-hand motif and adjacent sequences to target the cytoplasmic Wnt …
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Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
Late in Drosophila embryogenesis the cells giving rise to most of the larval tissues switch from a mitotic cycle to the endo cycle. The endo cycle consists of only S phase and a gap phase, leading to polyteny. It is preceded by the first detectable G1 period in Drosophila embryogenesis and …
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Structural Studies of Hmg-D-Dna Interactions
… chromosomal protein abundant in early Drosophila embryogenesis. It is a member of the HMG1/2 family of proteins, all of which share the HMG domain, a small DNA-binding structural motif. HMG1/2 proteins interact directly with nucleosomes, modulate chromatin structure, and modulate the …
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piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis
… transgenerational genome integrity. In Drosophila melanogaster ovaries, piRNA-Piwi complexes localise to the nucleus and scan nascent transcripts for transposon expression by using complementary antisense piRNAs as guides. Following target engagement, the gonad-specific protein Panoramix …
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Regulation of Progression through Unperturbed Mitosis and in the Presence of Environmental Stress
… a first part, I have addressed the function of Drosophila Separase, a protease which has been implicated in several regulatory processes in budding yeast. Although an essential role of this protease for sister chromatid separation has been demonstrated in a wide range of eukaryotes, its …
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Interphase chromosome movement during the midblastula transition in Drosophila melanogaster
… changes of interphase chromatin, at a time in Drosophila embryogenesis when many nuclear processes were just beginning to be established. I reasoned that cycle 14 was the ideal time in which to observe chromatin changes as a result of functional processes. During this embryonic stage cellular …
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Investigating the cell surface code for compartment boundary formation in Drosophila embryos
… such as cell division and cell rearrangement. At Drosophila compartment boundaries, supracellular actomyosin cables mechanically prevent the mixing of cells of different identity between compartments. We know some of the signalling pathways and transcription factors that control actomyosin …
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Exploring the transcriptomic landscape of the Drosophila melanogaster embryonic salivary gland.
… a simple model of tubulogenesis found in the Drosophila melanogaster embryonic salivary gland. Once specified, two mirror-symmetric placodes internalise from a flat epithelium in a coordinated manner, form two narrow-lumen epithelial tubes on the inside and eventually fuse to form a Y-shaped …
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Odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos
… of Opa expression during different stages of embryogenesis, and (3) specific molecular mechanisms by which Opa might interact with other proteins to directly regulate target gene expression.</p>