Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Drosophila embryo"”.
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Organization principles of the early Drosophila embryo
… principles observed from the developing embryos of the fruit fly Drosophila melanogaster: the Histone Locus Body size control and cortical migration of nuclei. The Histone Locus Body (HLB) is an evolutionarily conserved nuclear body that regulates the transcription and processing of …
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Imaging Drosophila embryo gastrulation to identify stress fields and biomechanical feedback
… phase of Ventral Furrow Formation (VFF) in the Drosophila melanogaster embryo. Detailed imaging of the underside of the embryo allows us to analyze how morphological aspects of cell clusters change over time. We have used confocal microscopy to take high-resolution time-lapsed images of living …
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Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development
… their regulation is not well understood. The Drosophila Synaptotagmin-like protein, Bitesize (Btsz), organizes actin at epithelial cell apical junctions in a manner that depends on its interaction with the actin-binding protein, Moesin. Here, I show that Btsz functions in actin reorganization …
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A statistical model relating transcription factor concentrations to positional information in the early Drosophila embryo
… the data set. This is the precellular Virtual Embryo from the Berkeley Drosophila Transcription Network project. It comprises expression measurements of almost 100 genes in more than 6,000 individual nuclei at six time points. Different modelling approaches are evaluated in the context of this …
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Genome-wide prediction of developmental enhancers and analysis of evolutionary plasticity in Drosophila
The early Drosophila embryo is a model for the study of transcriptional control of development. A pre-requisite for the development of the Drosophila embryo is a precise and coordinated control of gene expression, both spatially and temporally. This process of complex transcription regulation is …
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Centrosome-organized plasma membrane infoldings linked to growth of a cortical actin domain
… changing PM topography coupled? At the syncytial Drosophila embryo cortex, centrosome-induced actin caps grow into dome-like compartments for mitoses. We found the nascent cap to be a collection of PM folds and tubules formed over the astral centrosomal MT array. The localized infoldings require …
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Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
During embryonic development, epithelial tissues grow and undergo dramatic changes to adopt complex shapes. Coordinated cell behaviors, including oriented cell divisions are crucial to the proper development of epithelia. How forces are transmitted across the developing embryo and how these forces …
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On Different Uses of Abstraction in Models of Developmental Systems
… approach to studying gap gene patterning in the Drosophila embryo. This work highlights that some of the core ideas in Marr’s approach are, often implicitly, present in the literature regarding patterning systems however without the appropriate intellectual infrastructure to support them they …
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The Intracellular Domain of the Frazzled/Dcc Receptor is a Transcription Factor Required for Commissural Axon Guidance
During embryonic development, conserved families of attractive and repulsive cues steer axons by signaling through receptors that are expressed on axonal growth cones. In the canonical model of axon guidance receptor signaling, ligand binding induces the formation of protein complexes on receptor …
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The Role of the ORB2 RNA-binding Protein in Post-transcriptional Regulation
… mechanisms are employed during the early Drosophila embryo and it has been established as a system well suited for the study of these mechanisms. In Drosophila, ORB2 is an RBP expressed in the early embryo. It has been shown to regulate translation of bound mRNAs, but relatively little is …
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Frazzled And Abelson Interact To Regulate The Actin Cytoskeleton In Drosophila
… of the posterior commissures in a developing Drosophila embryo. The cytoplasmic tyrosine kinase, Abelson Kinase (Abl) enhances the loss of commissures observed in fra mutant. Abl physically interacts with Frazzled to help guide commissural axons across the midline. Furthermore, the loss of …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… network. Using the genetically manipulable Drosophila embryo and high resolution single cell analysis, I examined the function of commissureless, netrin, roundabout, and frazzled during neural development. Analysis of the individual axon pathways of RP3, V, and RP2 in wildtype and …
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Cell Topology Change by the Physical Engagement of Neighboring Cytoskeletal Networks
… metaphase furrowing mechanism of the syncytial Drosophila embryo. Prior to furrowing, an actin cap, consisting of Sponge (Spg, a Rac GEF), SCAR/WAVE, and Arp2/3, forms on top of each nucleus. Each cap is encircled by actomyosin borders, enriched with Rho signaling effectors (Rok, myosin, Dia, …
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The Molecular Basis of Tissue Elasticity and Force Balance During Drosophila Gastrulation
… working in biological tissue such as an early Drosophila embryo, there is no existing way to directly measure morphogenetic forces, and the relative contributions of forces in various cellular domains remain unknown. To begin, I studied gastrulation in a genetic background where basal membranes …
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Engineering Optogenetic Control of Endocytic Recycling: Controlling Rab11 Function in Drosophila melanogaster using Engineered Light-Responsive Nanobodies
… the development and survival of many organisms. Drosophila mutants for the Rab11 gene are not viable, where lethality manifests during embryonic development. This early lethality has imposed significant limitations on elucidating the immediate effects of Rab11 inhibition. Thus, the goal was to …
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Probabilistic Model-Based Approach to Evolutionary Analysis of Non-Coding Sequences
… in the regulation of body patterning in the Drosophila embryo, reporting statistical evidence in favor of key evolutionary hypotheses related to regulatory elements and constraints on indels. We also propose a new simulation scheme for generating biologically realistic benchmarks for the …
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HEM-protein regulates cell migration and asymmetric cell division during development of the ventral nerve cord in Drosophila melanogaster
… in the ventral nerve cord (VNC) of the Drosophila embryo to investigate the regulation of neuronal migration and asymmetric cell division during development of the nervous system. I have discovered a migration defect of RP2 neurons in HEM-protein (Hem) mutants: RP2 neurons cross the …
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Computational discovery of Cis-regulatory elements in multiple drosophila species
… patterns of gene expression in D. melanogaster embryogenesis to identify sets of developmentally co-expressed genes. We developed a computational method that identifies DNA binding sites for transcription factors from families of co-regulated genes that are expressed during Drosophila embryo …
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An analysis of the role of microtubules during tubulogenesis in Drosophila
… used the formation of the salivary glands in the Drosophila embryo, which are formed by coordinated apical constriction and invagination of a polarised epithelial placode, as a model to understand these changes. The role of microtubules (MTs) during morphogenetic processes such as this are not …
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