Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Drosophila development"”.
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FKBP14 in Notch Signalling and Drosophila Development
… activity of the complex are unclear. A screen in Drosophila identified FKBP14, an FK506-binding proteins (FKBP), as a genetic modifier of Presenilin (Psn), with FKBP14 mutants exhibiting defects typical of loss of Notch signalling. FKBPs are highly conserved and involved in a wide array of …
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Functional Analysis of Mars (CG17064) in Drosophila Development
… dieser Arbeit konnten wir zeigen das Mars, ein Drosophila Protein mit Sequenzähnlichkeit zu dem Vertebraten HURP (= hepatoma upregulated protein), für die Aufrechterhaltung und Integrität der mitotischen Spindeln benötigt wird. Über 90 Prozent der Embryonen, welche von weiblichen Mars Mutanten …
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The regulation of DNA replication during Drosophila development
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Functional characterization of the gene schlappohr (CG7739) during Drosophila development
… schlappohr (shlp) während der Entwicklung von Drosophila melanogaster (Drosophila) untersucht. shlp kodiert ein evolutionär hoch konserviertes Protein mit bisher unbekannter Funktion. Shlp wurde ursprünglich in einem Hefe-2-Hybrid Screen mit dem hochkonservierten N-Terminus von Bazooka (Baz), …
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Investigating processing body condensation, material properties and function during early Drosophila development
… storage, translation, and degradation. During Drosophila oogenesis, several maternal mRNAs are stored and translationally repressed inside P bodies before they are translated and degraded in the early embryo. How P bodies differentially regulate maternal RNAs is not fully understood. Using a …
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Determining the differential roles of the dock family of GEFs in drosophila development
… B, C, and D), complicate genetic analysis. Drosophila melanogaster is an excellent genetic model organism to understand Dock protein function as its genome encodes one ortholog per subfamily: Myoblast city (Mbc; Dock- A) and Sponge (Spg; Dock-B). The target GTPase of the Dock-A subfamily is …
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Delineation of the molecular mechanisms underlying DNA replication initiation and changes in gene copy number during Drosophila development
… of differential DNA replication programs in Drosophila has provided important insight into the molecular control of replication initiation and fork progression during development. We investigated the mechanisms by which binding of the origin recognition complex (ORC) and replication fork …
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Appearance Based Stage Recognition of Drosophila Embryos
Stages in Drosophila development denote the time after fertilization at which certain specific events occur in the developmental cycle. Stage information of a host embryo, as well as spatial information of a gene expression region is indispensable input for the discovery of the pattern of gene-gene …
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Drosophila as a model for the Anopheles Malpighian tubule
… processes which are essential for insect development and survival. As the Malpighian tubules contain many ion channels and transporters, they could be an effective tissue for targeting with novel pesticides to control populations of Diptera. Many of the insecticide compounds used to …
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Genetic analysis of Polycomb group interactions in imaginal discs of Drosophila Melanogaster and transposon tagging of the Asx Gene
… for the maintenance of determination during Drosophila development. Previous studies have examined interactions between homozygous members of the Polycomb (Pc) Group. These studies suggest interactions occur between the members of the Pc Group but cannot provide definitive conclusions as to …
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The Metabolic Transitions Regulated by the Estrogen-related Receptor (ERR) in Drosophila melanogaster
… the metabolic transition induced by hypoxia and development. First, we investigate how dERR influences hypoxic adaptation in Drosophila melanogaster. We find that dERR is required for a competent hypoxic response alone, or together with hypoxia inducible factor (HIF), which is the main …
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Mechanisms of myosin regulation and function during tissue folding
Throughout organismal development, precise three-dimensional organization of tissues is required for proper tissue function. These three-dimensional forms are generated by coordinated cell shape changes that induce global tissue shape changes, such as the transformation of an epithelial sheet into …
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piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis
… transgenerational genome integrity. In Drosophila melanogaster ovaries, piRNA-Piwi complexes localise to the nucleus and scan nascent transcripts for transposon expression by using complementary antisense piRNAs as guides. Following target engagement, the gonad-specific protein Panoramix …
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Genome-wide prediction of developmental enhancers and analysis of evolutionary plasticity in Drosophila
The early Drosophila embryo is a model for the study of transcriptional control of development. A pre-requisite for the development of the Drosophila embryo is a precise and coordinated control of gene expression, both spatially and temporally. This process of complex transcription regulation is …
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Investigating the evolution and functionality of closely related Wnt ligands in Drosophila melanogaster
… plays a pivotal role in orchestrating diverse developmental processes across metazoans. There are thirteen subfamilies of Wnt ligands, seven of which are represented in the model organism Drosophila melanogaster. Similar expression of some Drosophila Wnt genes has been observed in several …
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Modeling human Usher syndrome during Drosophila melanogaster development
… are not well understood. Here, I identified Drosophila melanogaster genes related to human Usher syndrome and characterized some of them (Cad99C, DSANS and crinkled) during Drosophila development, in the processes of microvilli morphogenesis in the follicular and wing imaginal disc epithelia. …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
… targets for brain regeneration therapies. Drosophila melanogaster is an excellent model for understanding NSC quiescence. The NSCs in Drosophila transit between quiescence and proliferation. The transcriptional profiles of quiescent and active NSCs have been determined, which reveal genes …
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AN INVESTIGATION OF THE MECHANISMS OF GROUCHO MEDIATED TRANSCRIPTIONAL REPRESSION
Groucho (Gro) is the Drosophila member of an evolutionarily conserved family of proteins that act as co-repressors for a wide range of transcription factors and includes four orthologs in humans, known as Transducin-like enhancer of split proteins (TLE1-4). This family of co-repressors play crucial …
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Characterization of Gf a Drosophila trimeric G protein alpha subunit
In the morphogenesis of tissue development, how coordination of patterning and growth achieve the correct organ size and shape is a principal question in biology. Efficient orchestrating mechanisms are required to achieve this and cells have developed sophisticated systems for reception and …
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Function and inhibition of the mitochondrial O-GlcNAc transferase isoform
… approach, based on the permeabilisation of Drosophila embryos, enabled the penetration of goblins into the organisms with consequent reduction of global O-GlcNAc levels. This method allowed the use of these novel bisubstrate inhibitors in vivo for the first time, with potential applications …
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