Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Drosophila Proteins"”.
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Characterisation of the dead ringer gene of Drosophila melanogaster
… specificity led to a screen that identified Drosophila proteins able to bind a consensus homeo domain site. One clone isolated in this screen produced no homeo domain and was selected for further characterisation as a protein with an unknown DNA binding domain and the potential to interact …
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Centrosomin Self-Assembly and Centrosomal Protein Recruitment
… matrix and from there other centrosomal proteins 'load' onto the centrosome, including gamma-tubulin. Centrosomes are non-functional without the addition of Cnn since it is responsible for recruitment of other centrosomal proteins. There are two conserved motifs in Cnn protein, currently …
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Communal Cell Death and P53 Mediated Transcriptional Control in Drosophila Melanogaster
The file named "LinkNichole.pdf" is the primary dissertation file. Supplemental QuickTime video files are also available ("movieS1-LinkNichole.mov", "movieS2-LinkNichole.mov", "movieS3-LinkNichole.mov").
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Bcl-2 Function in Drosophila
… pro- and anti-apoptotic Bcl-2 family members. Drosophila encodes two Bcl-2 family members, Debcl (pro-apoptotic) and Buffy (anti-apoptotic). To understand the role of Debcl in Drosophila apoptosis, we produced an authentic null allele at the Debcl locus. Although gross development and lifespans …
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Genetics of Stress-Induced Responses in Drosophila
… upon interaction with adaptor molecules. The Drosophila adaptor protein Dark, a homolog of nematode Ced-4 and mammalian Apaf-1, regulates the apical caspase Dronc, through interactions involving respective caspase recruitment domains (CARD). Dronc is the only caspase in the fly genome with a …
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Klonierung und funktionelle Analyse des Aktinreorganisators p150-Spir
… Genetische Studien an der Fruchtfliege Drosophila melanogaster konnten eine Rolle des Drosophila-JNK-Homologs DJNK(basket) in der Regulation von Zellbewegungen und Zellmorphologieänderungen während der Drosophila-Embryogenese zeigen. Inhibierung der Funktion von DJNK auf allen Stufen der …
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Feedback Regulation of Wnt Signaling by Naked Cuticle (Nkd) During Drosophila Embryogenesis
… defects, cancer, osteoporosis, and diabetes. In Drosophila, the naked cuticle (nkd) gene antagonizes the Wnt/beta -catenin signaling in every segment of the embryo. Nkd is a modular, evolutionarily conserved protein that uses an EF-hand motif and adjacent sequences to target the cytoplasmic Wnt …
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Histone Demethylase LSD1 Restricts the Size of the Germline Stem Cell Niche in Drosophila Ovaries
… to ensure proper tissue homeostasis. I use the Drosophila female germline as an excellent model system to study niche development and function. Five to seven somatic cap cells form the ovarian stem cell niche and produce dpp, a BMP homolog necessary for the maintenance of germline stem cells …
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The Role of the Scaffolding Protein INAD in Localization of Signaling Complexes to the Rhabdomeres of Drosophil Photoreceptors
Organization of proteins into macromolecular complexes is one way cells maximize the speed, specificity, and efficiency of signal transduction. In fruit fly photoreceptors InaD, a scaffolding protein containing 5 PDZ domains, organizes proteins involved in the visual signaling pathway into …
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Dynamic Scaffolding in a G-Protein Signaling Cascade
The file named "mishraprashant.pdf" is the primary dissertation file. Supplemental movie files ("Mishra_Movie_S1.mpg", "Mishra_Movie_S2.mpg") are also available.
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
… of adipose tissues. To address this question, Drosophila and mammalian models were used to analyze its potential role. Components of the Hh pathway were expressed in the Drosophila fat body. Activating Hh signaling specifically in fat body inhibited fly fat formation. Conversely, blocking Hh …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… sought to better understand a family of unusual proteins called the MICALs (which includes one Drosophila Mical and three vertebrate MICALs), which associate with the Semaphorin cell-surface receptor Plexin and are important for Semaphorins to exert their effects. Nothing was known, however, …
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Apoptosis Determinants in Drosophila Melanogaster
The file named "chewsu.pdf" is the primary dissertation file. All other files ("*.mov") are supplemental files and may be viewed individually.
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… sought to better understand a family of unusual proteins called the MICALs (which includes one Drosophila Mical and three vertebrate MICALs), which associate with the Semaphorin cell-surface receptor Plexin and are important for Semaphorins to exert their effects. Nothing was known, however, …
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Genetic Analysis of Fic-Mediated BiP AMPylation in Photoreceptors
… cells from the accumulation of misfolded proteins in the ER. Depending on ER stress levels, the ER-resident Fic protein catalyzes AMPylation or deAMPylation of BiP, the major ER chaperone. This work elucidates a critical role of the reversible AMPylation of BiP in maintaining the …
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A Novel Role for Odorant Binding Proteins in Deactivation of Drosophila Olfactory Neurons
In insects, odorant binding proteins are a large and diverse group of low molecular weight proteins secreted into the fluid bathing olfactory and gustatory dendrites. The best-characterized OBP, known as LUSH, is required in Drosophila melanogaster for the detection of physiological levels of the …
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Regulatory Mechanism of the RNAi Pathway
… into small interfering RNA (siRNA). In Drosophila, Dicer2 and R2D2 coordinately recruit duplex siRNA to the effector RNA-induced silencing complex (RISC), wherein single-stranded siRNA guides the endoribonuclease Argonaute (Ago) to catalyze sequence-specific cleavage of complementary …
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Rbfox1 Regulates mRNA Translation to Promote Germ Cell Differentiation
… cyst development remain poorly understood. In Drosophila, germline stem cells (GSCs) undergo an asymmetric division, giving rise to a stem cell and a cystoblast that then divides four times to produce a 16-cell germline cyst. This 16-cell cyst will then continue differentiation until it forms a …
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Uncovering Reversible AMPylation of BiP Mediated by dFic During ER Homeostasis
… function of AMPylation in eukaryotes, we used Drosophila melanogaster as our genetic model organism and created mutant flies lacking functional Drosophila Fic (dFic). We found that the flies without enzymatic function of dFic exhibit blind phenotype due to impaired synaptic transmission. dFic …
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The Roles of Codon Usage in Translational and Transcriptional Regulation on Gene Expression
… This process is conserved from Neurospora to Drosophila. In addition, I demonstrate that the premature termination of translation is mediated by the canonical release factor eRF1, which recognizes ribosomes stalled at nonoptimal codons. Together, I propose a model that explains the impact of …
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