Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Dravet syndrome"”.
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Diverse Mechanisms Impair Thalamic Circuit Function in a Dravet Syndrome Mouse Model
Dravet syndrome (DS) is an infantile epileptic encephalopathy that is caused by loss-of-function mutations in the SCN1A gene, which encodes the voltage-gated sodium channel, NaV1.1. Haploinsufficiency of NaV1.1 in DS patients leads to imbalanced excitability across brain circuits, resulting in a …
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INTERNEURON TRANSPLANTS AS A TREATMENT FOR SEIZURES AND SOCIAL DEFICITS IN A MOUSE MODEL OF DRAVET SYNDROME
… by selective interneuron dysfunction, such as Dravet syndrome. Dravet syndrome (DS) is a treatment-resistant pediatric epilepsy caused by loss of function variants in SCN1A, which codes for the voltage-gated sodium channel subunit Nav1.1. DS is also characterized by high rates of autism …
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Characterizing the Developmental and Reproductive Toxicities of Cannabidiol and Δ9-Tetrahydrocannabinol
… treatment of drug-resistant epilepsy, such as Dravet Syndrome (DS) which is diagnosed in children as young as two months. While CBD has shown anecdotal and recently clinical trial efficacy in reducing seizure frequency in DS patients, little is known about the potential adverse side-effects on …