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Showing 1 to 20 of 43 for “"Dppc"”.
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Sorption de tensioactifs cationiques (R-Pyr+Br-) par des vésicules de DPPC et conséquences sur leur transition thermotropique
… des vésicules de lipalmitoylphosphatidylcholine (DPPC) en fonction de la température et nous avons mesuré l'effet de cette sorption sur les paramètres (température, volume et coopérativité) de la transition de ces vésicules. Les tensioactifs utilisés sont thermotropique les bromures l'undécyle, de …
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Development and in vivo Analysis of Inhaled Clofazimine for the Treatment of Pulmonary Tuberculosis
… – lactate) with dipalmitoylphosphatidylcholine (DPPC) were prepared in 80 : 20 ratios of CFZ or CFZ-salt to DPPC using aqueous spray drying of suspensions. The resulting powder formulations were characterized for, batch yield, drug content, hydrodynamic and aerodynamic particle size distribution, …
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Synthetic Micellar Complexes of Apolipoprotein a-I With Lipids as Substrates for Human Lecithin Cholesterol Acyltransferase
… (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg phosphatidylcholine (egg-PC). The formation of complexes was examined at increasing cholesterol contents with DPPC, and at 20 mole % cholesterol contents for DMPC, DPPC, and egg-PC.
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Measurement of forces between and within bilayers of neutral phospholipids
… of frozen dipalmitoylphosphatidylcholine ( DPPC ), melted DPPC, egg phosphatidylethanolamine or equimolar mixtures of DPPC and cholesterol ( DPPC/CHOL ), Concurrently the structural changes that resulted from this water removal were measured using X-ray diffraction. The work was divided into …
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The use of enzymes, isomerisable lipid analogues and small molecules to modulate the structure and dynamics of lipid bilayer
… dipalmitoyl-sn-glycerol-3-phosphocholine-d62 (d62-DPPC) samples containing cholesterol and the serotonin receptor agonist drugs quipazine and LY-165,135 was analysed using proton and deuterium NMR spectroscopy and differential scanning calorimetry (DSC). The effect of quipazine and LY-165,135 on …
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Effect of Structure and Composition of Reconstituted High Density Lipoproteins on Phosphatidylcholine Transfer by Human Plasma Phospholipid Transfer Protein
… containing radiolabelled dipalmitoyl-PC ($\sp $C-DPPC) were used as donors and varied rHDL, consisting of apolipoprotein, phospholipid and cholesterol, were used as acceptors. PLTP, purified about 3,400-fold, was used in the experiments. Activity was measured by the percent $\sp $C-DPPC …
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Determination of the Site of Ultrasonic Absorption in Suspensions of Large Unilamellar Vesicles
… (w/w) mixture of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG)) in the vicinity of their phase transition temperature (t$\sb{\rm m}$), using a double crystal acoustic interferometer. LUV suspensions absorb ultrasound highly near t$\sb{\rm m}$, and $\alpha\lambda$ …
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Validation of the charge equilibration lipid force field for simulations of phospholipid membranes with an application to the study of the free energetics of methyl guanidinium permeation across a DPPC bilayer
… fields by extending to simulations of a model DPPC-water monolayer. Several physical and electrostatic properties have been calculated for comparison with previously re-ported experimental and computational studies including component density profiles, deuterium order parameters, surface …
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Thermodynamic Evidence That Ganglioside-Mediated Insertion Of Botulinum A Into The Cholinergic Nerve Ending May Precede Endocytosis And Acidification: A Langmuir Film Study
… mica supported dipalmitoylphosphatidylcholine (DPPC) lipid bilayers. As an alternate technique, DPPC/GT1b or total ganglioside extract (80:20) monolayers of a Langmuir Blodgett (LB) Trough were adapted to be artificial membrane models for toxin insertion studies. We conclude that LB monolayer …
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Interaction of Human Apolipoprotein a-I With Dipalmitoyl Phosphatidylcholine
Dipalmitoylphosphatidylcholine (DPPC) bilayer lipid will react with human apolipoprotein A-I (apo A-I) to form lipid-protein micellar complexes. The reactivity of the lipid bilayer is dependent upon the physical state of the vesicle. Large vesicles with essentially planar bilayers do not form …
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High-pressure NMR studies of model membranes and Kramers turnover on solution
… relaxation times of phospholipid model membranes DPPC in multilamellar dispersions and in unilamellar vesicles have been investigated by using $\sp{31}$P NMR, $\sp2$H NMR, as well as one and two dimensional $\sp1$H NMR techniques in both the liquid crystalline and various gel phases. The results …
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Development of Liposome Drug Delivery Systems for Anti-Glioma Therapy
… different lipid phases: SPC:Chol, HSPC:Chol or DPPC:Chol in 1:1 mole ratio were used in each liposomal formulation to compare their size, size distribution, zeta potential, pH and morphology. The size of the liposomes was then reduced into nanometre size range. DPPC-liposomes entrapped 70-85% of …
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Epicutaneous Delivery of Allergens Using Dual Stimuli-Responsive Liposomes-Loaded Dissolving Microneedles
… liposomes, using thermo-responsive (DPPC/DOPE/STG) and dual heat- and sPLA-responsive (DPPG/DPPC/STG), had average diameters of 154.6 ± 1.1 nm and 164.8 ± 2.0 nm, respectively. Encapsulation efficiency in DPPC/DOPE/STG was lower at 20% with mixed allergens (e.g., crude peanut …
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Interakce modifikovaných polymerů s liposomy
… doručování léčiv. Přestože příprava liposomů z DPPC čelila problémům kvůli kvalitě chemikálií, metoda ethanolového přikapávání vedla k tvorbě stabilních liposomů. Tyto liposomy prokázaly dobrou velikost a stabilitu, a jejich interakce s palmitoyl hyaluronátem sodným naznačila potenciál pro …
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Structural and functional studies of the C-terminal domain of human apolipoprotein A-I: Limited proteolysis and deletion mutagenesis
… with apoA-I and dipalmitoyl phosphatidylcholine (DPPC) or palmitoyloleoyl PC (POPC) by chymotrypsin, trypsin, elastase, or subtilisin generated a major fragment of $\sim$22 kDa. Under milder conditions proteolysis of lipid-free apoA-I produced a fragment of similar size. The fragments shared the …
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Surface Functionalisation of Metal-Organic Frameworks for Biomedical Applications
… and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)—to enhance its internalisation in cancer cells. The coated MOFs underwent a full physicochemical characterisation using powder X-ray diffraction, various microscopy techniques, dynamic light scattering, and zeta potential, among others. These …
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Structure and Dynamics of Biomembranes containing Cholesterol and other Biologically-Important Sterols : a computational perspective
… of a model dipalmitoyl phosphatidylcholine (DPPC) membrane were examined using Molecular Dynamics (MD) simulations and Neutron Scattering (NS) calculations. As a necessary step towards realistic sterol:biomembrane simulations, molecular mechanics force field parameters for cholesterol, …
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Lipid studies in breath-hold diving mammals and obese, pre-diabetic mice.
… and dipalmitoylphosphatidylcholine (DPPC) levels compared to deeper divers (Weddell seals, Leptonychotes weddellii). Additionally, in comparing ringed seal (Pusa hispida) skeletal muscle to liver tissue, liver tissue showed significantly higher levels of C16:0 sphingomyelin, …
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Identification and imaging different lipid species within phase-separated model membranes by integration of TOF-SIMS and principal component analysis
… 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), according to variations in the relative intensities of their fragment ions. PCA of TOF-SIMS spectra acquired slightly above the static limit enabled imaging the distributions of these …
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Understanding correlations between secondary relaxations and thermal behaviour of biologically relevant molecules
… 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) with acyl chain lengths of 12, 14, 16 and 18, respectively has been examined at temperatures below the chain melting transition temperature (Tm). The results show that increasing the acyl …
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