Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Dppa4"”.
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The roles of DPPA2, DPPA4 and SMARCA5 in mouse zygotic genome activation, epigenetic reprogramming and development
… identified the small DNA binding proteins DPPA2, DPPA4 and the chromatin remodeler SMARCA5 as potential inducers of major ZGA. Here I focus on validating these three factors and I assess their roles in vivo, using conditional knock-out mouse models and a targeted protein depletion system, together …
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Investigating the role of DPPA2 and DPPA4 in the Epigenetic Control of Lineage Programs in Human Embryonic Stem Cells
… a role for the transcription factors DPPA2 and DPPA4 in maintaining poised chromatin in human pluripotent stem cells (hPSCs). I found that DPPA2/4 bind to the majority of CpG islands, poised promoters and a large subset of poised enhancers. CRISPR-Cas9 mediated knockout of DPPA2/4 in primed …
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Studies on approaches for sequencing cytosine modifications and the identification of their protein readers
… the epigenetic priming factors Dppa2 and Dppa4 as combination-specific interactors of 5-hydroxymethylcytosine, though the mechanism of these proteins’ interaction with 5-hydroxymethylcytosine requires further work to be conclusively determined.
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… the expression of CSC-related genes, DPPA4, ESRRB and TCL1A, and β-catenin target genes, BCL2L2 and COX2 were significantly suppressed with Pao and Rau treatment. The tumorigenicity was also inhibited by Pao and Rau in subcutaneous pancreatic cancer xenograft mouse models. Pao and Rau …