Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Doxorubicin-induced cardiotoxicity"”.
-
The effect of Aspalathin on Doxorubicin-induced Cardiotoxicity
Doxorubicin is a highly effective first-line chemotherapeutic agent used in the treatment of a broad range of solid and hematological tumors. Though effective, the use of Doxorubicin in cancer therapy has been hindered by its cardio toxic side effects. As yet, no single chemical synthesized drug or …
-
Dysregulation of connexin-43 (cx43) in doxorubicin-induced cardiotoxicity
The chemotherapeutic drug doxorubicin (DOX) is widely used in the treatment of cancer; however patients experience dose-dependent cardiotoxicity that can manifest acute, early- and late-onset chronic and is associated with a decreased contractility and dilated cardiomyopathy. Similar effects have …
-
Ethanolamine as a cardioprotective agent in doxorubicin-induced cardiotoxicity
Introduction: Doxorubicin is an anthracycline chemotherapeutic drug prescribed to approximately 50% of paediatric cancer patients as it effectively treats a wide range of tumours. However, like most anticancer drugs, it is associated with debilitating side effects, including cardiotoxicity. …
-
Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… effects of pifithrin-α and melatonin against doxorubicin-induced cardiotoxicity. Doxorubicin was injected at a dose of 22.5 mg/kg (i.p.) in mice to induce cardiotoxic effects. Meanwhile, doxorubicin caused a significant increase of cardiac cell apoptosis following injection (14.2 ± 1.1% for …
-
Doxorubicin-Induced Cardiotoxicity Is Mediated By Neutrophils Through Release of Neutrophil Elastase
<p>Doxorubicin (Dox) is one of the most effective chemotherapy agents that is used for the treatment of childhood cancer. Unfortunately Dox treatment can cause damage to the heart. Indeed, childhood cancer survivors are at a higher risk of developing a cardiovascular disease at an earlier age. The …
-
The protective effect of α-lipoic acid in doxorubicin induced cardiotoxicity in rats.
… dose of the widely used chemotherapy agent doxorubicin. α-Lipoic acid significantly enhanced the survival of rats exposed to a lethal dose of doxorubicin (p<0.001). Morbidity was proportionally higher in rats treated with doxorubicin alone in contrast to rats treated with both doxorubicin …