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Showing 1 to 20 of 291 for “"Doxorubicin"”.
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The effect of Aspalathin on Doxorubicin-induced Cardiotoxicity
Doxorubicin is a highly effective first-line chemotherapeutic agent used in the treatment of a broad range of solid and hematological tumors. Though effective, the use of Doxorubicin in cancer therapy has been hindered by its cardio toxic side effects. As yet, no single chemical synthesized drug or …
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Regulatory Mechanisms of Mitotic Catastrophe Induced by Doxorubicin
PURPOSE: Doxorubicin may act through DNA intercalation/binding, inhibition of topoisomerase II, free radical generation, or damage to cell membranes and induce apoptosis, senescence or mitotic catastrophe. Because low dose of doxorubicin induce senescence or mitotic cell death, we attempted to …
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Doxorubicin Inhibits Cardiomyocyte Autophagic Flux by Suppressing Lysosomal Acidification
The clinical use of doxorubicin is limited by cardiotoxicity. Dysregulation of autophagy in the myocardium has been implicated in a variety of cardiovascular diseases. However, the role of autophagy in doxorubicin cardiomyopathy remains poorly defined. Most models of acute doxorubicin …
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Dysregulation of connexin-43 (cx43) in doxorubicin-induced cardiotoxicity
The chemotherapeutic drug doxorubicin (DOX) is widely used in the treatment of cancer; however patients experience dose-dependent cardiotoxicity that can manifest acute, early- and late-onset chronic and is associated with a decreased contractility and dilated cardiomyopathy. Similar effects have …
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Ethanolamine as a cardioprotective agent in doxorubicin-induced cardiotoxicity
Introduction: Doxorubicin is an anthracycline chemotherapeutic drug prescribed to approximately 50% of paediatric cancer patients as it effectively treats a wide range of tumours. However, like most anticancer drugs, it is associated with debilitating side effects, including cardiotoxicity. …
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Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
… study, we demonstrated that the anthracycline doxorubicin selectively eliminates MDSC in the spleen, blood and tumor beds. Furthermore, five days after doxorubicin treatment residual MDSC exhibited impaired suppressive function, which correlated with reduced reactive oxygen species (ROS) …
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The effect of doxorubicin on the U2OS cell cycle
… of U20S cells with the chemotherapeutic drug Doxorubicin results in either apoptosis or cellular senescence. The pathway the cell takes is dependent upon the dosage of Doxorubicin administered to the cells. When a 10 [mu]M dose is administered Topoisomerase II is inhibited resulting in double …
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Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
… channel opener, would protect against chronic doxorubicin cardiomyopathy both in vivo and in vitro.Male ICR mice were randomized to 1 of 4 treatments: saline, sildenafil (0.7 mg/kg IP), doxorubicin (5 mg/kg IP), and sildenafil (0.7 mg/kg IP)+doxorubicin. Apoptosis was determined using the …
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Characterization and Reversal of Doxorubicin-Mediated Changes In Sensory Neurons
… lasting years after exposure to chemotherapy. Doxorubicin (DOX), a common chemotherapeutic agent, has been associated with memory impairments in humans and induces memory deficits in rodent models. DOX also impairs serotonin (5-HT)-induced long-term synaptic facilitation (LTF) in …
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Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… effects of pifithrin-α and melatonin against doxorubicin-induced cardiotoxicity. Doxorubicin was injected at a dose of 22.5 mg/kg (i.p.) in mice to induce cardiotoxic effects. Meanwhile, doxorubicin caused a significant increase of cardiac cell apoptosis following injection (14.2 ± 1.1% for …
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Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
… liposome formulation loaded with doxorubicin (Dox-TSL) has already shown substantial anti-tumor efficacy and is currently in clinical trials.</p><p> Previous pre-clinical work to understand the mechanism of efficacy has illustrated increases in overall drug concentration in the …
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mRNS expresszióbeli változások vizsgálata in vitro AN-152 és doxorubicin kezelés hatására
… és egy klasszikus kemoterápiás szernek, a doxorubicinnek a hatásának vizsgálta egy uvealis melanoma sejtvonal őssejt marker összetételére.
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Doxorubicin-Induced Cardiotoxicity Is Mediated By Neutrophils Through Release of Neutrophil Elastase
<p>Doxorubicin (Dox) is one of the most effective chemotherapy agents that is used for the treatment of childhood cancer. Unfortunately Dox treatment can cause damage to the heart. Indeed, childhood cancer survivors are at a higher risk of developing a cardiovascular disease at an earlier age. The …
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The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
Trans-arterial chemoembolization (TACE) with doxorubicin is commonly used to treat hepatocellular carcinoma (HCC), but has limited efficacy due to a high level of resistance. The factors that determine the sensitivity to TACE-doxorubicin are unknown. FOXO3 is a multifunctional transcription factor …
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Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
… und ausgewählte Nebenwirkungen des Zytostatikums Doxorubicin zu untersuchen. Dazu wurden die Plasmakonzentrationen von Doxorubicin und Doxorubicinol von 94 Krebspatienten durch HPLC analysiert. Die pharmakokinetischen Parameter wurden mit Hilfe von nicht-kompartimenteller und 2-kompartimenteller …
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Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer
… N-terminal (NH2- CWxEAAYQrFL-CONH2) linked to aldoxorubicin (Aldox), a modified version of a common chemotherapy drug doxorubicin (Dox). The cytotoxicity of the PDC and free Dox (positive control) were assessed against MDA-MB-231, MDA-MB-468, and MCF-10A cells using MTT assay. The PDC showed …
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Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… will be diagnosed with breast cancer. Currently, doxorubicin is one of the most effective chemotherapies for breast cancer. Unfortunately, up to 60% of survivors report long-term chemotherapy-induced cognitive dysfunction (CICD) characterized by deficits in working memory, processing speed, and …
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Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity
Although the antibiotic, doxorubicin (DOX), is a widely-used and successful first-line treatment for cancers, it can induce cardiotoxicity which is associated with increased production of myocardial reactive oxygen species (ROS). Recent work has suggested that ROS generated specifically from Nox2 …
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Exploration of a doxorubicin-polymer conjugate in lipid-polymer hybrid nanoparticle drug delivery
… of incorporating the drug-polymer conjugate doxorubicin-poly (lactic-co-glycolic) acid (Dox-PLGA) into a lipid-polymer hybrid nanoparticle (LPN). The primary difference in using a drug-polymer conjugate for NP drug delivery is the drug’s release kinetics. Dox-PLGA LPNs showed a more sustained …
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