Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 102 for “"Downstream effects"”.
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Surface triangulation and the downstream effects on surface flattening
… despite the reliance on the triangulation by the downstream application, there is very little work which has been focused on the inherent affects of the underlying triangulation on the performance or result of the application. Therefore, the impact of the triangulation on the downstream …
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Towards the downstream effects of insufficient content moderation on the internet
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Antibodies to Heterogenous Nuclear Ribonucleoprotein A1 Penetrate Neurons Leading to Multiple Downstream Effects Resulting in Neurodegeneration
… understanding of trafficking, deleterious effects, and in vivo effects of anti-hnRNP A1 antibodies and their implications in the disease Multiple Sclerosis.</p>
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Variability in the North Atlantic Deep Western Boundary Current : upstream causes and downstream effects as observed at Line W
The variability in the DWBC, its connection to the forcing in the northern North Atlantic and interaction with the Gulf Stream were explored from a combination of remote sensing and in-situ measurements in the western North Atlantic. Using satellite altimetry and Sea Surface Temperature (SST) we …
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Variability in the North Atlantic Deep Western Boundary Current : upstream causes and downstream effects as observed at Line W
The variability in the DWBC, its connection to the forcing in the northern North Atlantic and interaction with the Gulf Stream were explored from a combination of remote sensing and in-situ measurements in the western North Atlantic. Using satellite altimetry and Sea Surface Temperature (SST) we …
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An investigation of acute exercise and FGF21.
… increase in FGF21 nor the potential downstream effects of this increase are known. Similarly, little is known about the effect of biological sex or other types of exercise on circulating levels of FGF21. This dissertation will investigate the effects of two different types of exercise …
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Genetic Profiling in Soft Tissue Sarcoma
… that the gene fusion variants have distinct downstream effects. In Study III, 177 STS of mixed histopathological subtypes were profiled using cDNA microarrays. Distinct gene expression patterns were identified in subtypes with specific translocations or mutations. Herein, frequent …
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Screening for purine transporters in S. aureus
… an inability to transport purines but rather to downstream effects related to the toxicity of the purine biosynthesis inhibitors. A thorough understanding of S. aureus purine acquisition will allow for development of antimicrobials with prolonged effectiveness.
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Characterizing the landscape of aminoacyl-tRNA synthetase protein production in Bacillus subtilis
… Furthermore, linking changes in abundances with downstream effects on enzymatic output, pathway function, and ultimately cell fitness is unexplored in nearly all cases. Here I use a model enzyme family, the aminoacyl tRNA synthetases (aaRS), to explore how sensitive Bacillus subtilis are to …
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The developmental liver transcriptome of Rattus norvegicus
… development. The transcription factors and their downstream effects have been well studied in regards to early liver development, yet perinatal liver development is much less well understood. In an attempt to investigate this area of research, we developed a time course experiment including both …
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Defining interactions between Mycobacterium leprae and Langerhans cells
… cells interact and uptake M. leprae leading to downstream effects on T cell activation and overall immune responses. The hypothesis of this study is that M. leprae interacts with Langerhans cells via various cell surface receptors that influence a Th1 or Th2 immune response. This study …
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The influence the oceanographic variability has on the top predators of the sub-Antarctic domain
… a unique opportunity to study the fine-scale effects of thermal water column structure and upper ocean submesoscale processes on the diving behaviour and vertical foraging effort of SAFS. Seasonal and diel trends of foraging effort were investigated and compared to upper ocean thermal …
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Stochastic analysis of dense nonaqueous phase liquid dissolution in naturally heterogeneous subsurface systems
… concentration field to address both boundary and downstream effects. An extrapolation of the effective properties is performed for the large spatial variability of hydraulic and dissolution parameters. The extrapolation is evaluated using a unique two-zone model that simplifies the continuous …
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Caged phosphopeptides and phosphoproteins : agents in unraveling complex biological pathways
… burst of a specific species, allowing the downstream effects to be monitored without disrupting other aspects of the system. The syntheses and applications of caged phosphopeptides and phosphoproteins have been developed and detailed within this thesis. Two methods to synthesize …
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Caged phosphopeptides and phosphoproteins : probes to dissect the role of phosphorylation in complex signaling pathways
… of probes that enable researchers to observe the downstream effects of kinase-mediated phosphorylation in "real time" are presented in this thesis. The release of a physiologically-relevant concentration of a phosphopeptide with temporal and spatial control is accomplished by the photolysis of a …
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Interactions of shiga-like toxin-2 (Stx-2) from Escherichia coli O157:H7 and the Bcl-2 family of proteins during host cell programmed cell death
… select Bcl-2 family proteins, and outlined the effects that Stx-2 and a newly generated mutant of Stx-2 have on neutrophil apoptosis and necrosis rates as well as on caspase-8 and caspase-9 activation. Stx-2 did not bind to the select Bcl-2 family proteins examined nor did it consistently show …
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Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… Kinase 1 (Mnk1) relays signals to its major downstream target eIF4E. Activation of Mnk1 and subsequent phosphorylation of eIF4E results in changes in translation rates for subsets of mRNAs. Both the Erk1/2 and p38 MAPK pathways activate Mnk1 meaning that Mnk1 responds to growth signals …
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Liver fluke development: a target for parasite control?
… us to selectively deplete them and examine downstream effects. Using an RNA interference (RNAi) platform, the function of a key effector (fgfrA) was investigated and silenced juveniles exhibited a significant reduction in the number of EdU+ cells. The findings of this study highlight the …
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Revenge or Reconciliation? A Rejection-Based Model of Firm-Induced Relationship Termination
<p>This study is the first to examine the effects of firm-induced relationship termination on customer rejection perceptions and firm-related outcome behaviors. A research model is developed that focuses on several key issues with respect to the post-termination process. First, the study explores …
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