Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 4625 for “"Downstream"”.
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Optimization of Downstream Purification of Lucentis
A base case for the production and purification of the fragmented antibody, Lucentis, was explored and compared to several alternative cases that were hypothesized to optimize the purification process. The base case consisted of using a series of chromatography columns including anion exchange, …
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Should Oil-Producing Countries Go Downstream?
… already begun to vertically integrate into the downstream oil refining segment calls for a detailed examination of the implication of such investments. Oil-producing countries rely largely on the revenues from crude oil exports, while refining crude oil locally means increasing the use of crude …
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Transformación agile en el downstream de combustibles
La industria de los combustibles fósiles afronta una época de enormes desafíos relacionados a la transición energética, pero no es el único desafío que tiene por delante. Además de la electrificación de los automotores, otros cambios como las nuevas tecnologías enfocadas en la maximización de la …
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Supply chain practices in the petroleum downstream
… current supply chain practices in the petroleum downstream industry, using ExxonMobil as a case study. Based on the analysis of the literature and the interaction with industry experts, this work describes the main supply chain issues and challenges in the downstream sector. Moreover, supply …
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Downstream suspended sediment dynamics of reservoir sediment flushing
… of reservoirs and maintain sediment supply downstream of impounded rivers. Nevertheless, flushing of the accumulated sediments downstream of the dam also bears numerous negative impacts. In this study, first the most important downstream impacts of fine sediment releases of flushing were …
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FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
… that selective activation of signaling pathways downstream of a GPCR may lead to safer and more effective drug therapies. The dopamine D2 receptor is the main target in therapies for Parkinson’s disease and schizophrenia. First and second generation antipsychotic drugs antagonize dopamine D2 …
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Leveraging downstream data in the footwear/apparel industry
Retailers collect information regarding consumer purchases on a transactional basis. This data is not completely being leveraged by manufacturers in the footwear and apparel industry to increase on-shelf availability. However, certain apparel and consumer products companies have developed …
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Reynolds stress measurements downstream of a turbine cascade
… measure Reynolds stresses in the turbulent flow downstream of a large-scale linear turbine cascade. A rotatable X-wire hot-wire probe that allows redundant data to be taken with solution for mean velocities and turbulence quantities by least-squares fitting procedures was developed. This …
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Prkca: Identification of A Novel Downstream Target of Wt1
… in <em>WT1</em> result in dysregulation of downstream target genes, leading to aberrant kidney development and/or Wilms tumor. These downstream target genes are largely unknown, and identification is important for further understanding Wilms tumor development. Heatmap data of human Wilms …
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High-throughput Amplicon Sequencing Optimization for Downstream Prediction Purposes
… dataset produced with this project will supply downstream applications in pigmentation and facial morphology prediction modeling. This work also advances FDP toward wide-scale integration into forensic laboratories and demonstrates how SNP-based genotyping can extend investigative leads when …
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Surface triangulation and the downstream effects on surface flattening
… despite the reliance on the triangulation by the downstream application, there is very little work which has been focused on the inherent affects of the underlying triangulation on the performance or result of the application. Therefore, the impact of the triangulation on the downstream …
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Downstream Signal Transduction Pathway in Human Middle Ear Cholesteatoma
… In human middle ear cholesteatomas, the role of downstream signal transduction pathway through EGFR and PLC-γ1 seemed to be dominant for the proliferation and differentiation of the keratinocyte.
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Quality by design for the downstream processing of biopharmaceuticals
… is the most commonly used technology for downstream purification of biopharmaceuticals, tangential flow filtration (TFF) is probably the second most common unit operation in the manufacture of these products. To determine how QbD can be applied to TFF a case study is developed in applying …
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Precursors and downstream consequences of prediction in language comprehension
… I explore new avenues of research by examining downstream consequences of prediction during language comprehension on future recognition memory. Additionally, I test whether these consequences occur following any violation of predictions, or whether the semantic fit of the violation to the …
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Chronic activation and downstream mechanisms of programmed axon death
… pathway components, and explore the mechanisms downstream of SARM1 that drive axon degeneration. Using mice with graded levels of NMNAT2 protein, this thesis demonstrates that sub-heterozygous NMNAT2 expression reduces viability in a SARM1-dependent manner and partially activates SARM1 in …
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Streamwise vorticity enhanced compressible mixing downstream of lobed mixers
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1997.
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Flowfield Downstream of a Compressor Cascade with Tip Leakage
… with tip leakage was built. The flowfield downstream of the cascade was measured using four sensor hot-wire anemometers, from which the mean velocity field , the turbulence stress field and velocity spectra were obtained. Oil flow visualizations were done on the endwall underneath the blade …
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Turbulent flowfield downstream of a perpendicular airfoil--vortex interaction
… to document the turbulent flowfield produced downstream of an airfoil encountering an intense streamwise vortex. This type of perpendicular airfoil--vortex interaction commonly occurs in helicopter rotor flows. The experiments presented here thus provide useful information for the prediction …
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Downstream change in channel hydraulics along the River Severn, UK
… spaced at 1 km intervals between 4 km and 254 km downstream from the source. Channel hydraulic parameters showed considerable variability in both space and time, reflecting cross section geometry variation downstream. Mean velocity increased with distance downstream from 0.23 m s\(^{-1}\) to 1.72 …
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Local and downstream impacts of water reuse at power plants
This Thesis was approved for publication on 2015-11-23 at 10:31.
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