Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Doublecortin"”.
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Novel in vivo imaging approaches to study embryonic and adult neurogenesis in the mouse
… expressed in the neurogenic subpopulation of doublecortin positive cells. Tis21-GFP is inherited by the neurons and eventually degraded. Moreover, our data suggest that mitotic Tis21-GFP cells are an indicator of the levels of neurogenesis more accurate than doublecortin positive cells, in the …
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Chronic mild social stress increases neurogenesis in adolescent male rats
… proliferation or survival (evidenced by BrdU and Doublecortin (Dcx) immunohistochemistry respectively) of cells born at the beginning of the stress procedure. Compared to controls, BrdU-labeling showed chronic stress significantly increased proliferation of cells generated after the stressor had …
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The Role of Adult Neurogenesis in Cocaine Addiction
… as well as a 4 week delayed increase in doublecortin-positive (DCX+) immature neurons which were common to both rats in withdrawal or those continuing to self-administer cocaine. I next asked the question of the functional consequence of changes in adult hippocampal neurogenesis to the …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
… analyses using immunohistochemical staining for doublecortin (DCX), a marker expressed by immature neurons, revealed that DCX+ clusters co-express markers of neuronal cell migration (PSA-NCAM), GABAergic interneuron marker (GABA+), and specific transcription factors (SCGN+SP8+) associated with …
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Promoting Central Nervous System Regeneration by Targeting Intracellular Pathways
… stage. Four maturity markers were identified – doublecortin as an early maturity marker and 68-kDa neurofilament, calcitonin, tubulin-4a as late maturity markers. Some transcription factors showed promising results in rejuvenating primary cortical neurons. Further studies are needed to identify …
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Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
… vermehrt den immaturen neuronalen Marker Doublecortin (Dcx). Dieser Effekt ließ sich jedoch eher als Folge der TAT-Bcl-xL vermittelten Neuroprotektion auf NPC denn einer stimulierten neuronalen Differenzierung von NPC erklären. Eine Expression des neuronalen Markers NeuN konnte jedoch zu …
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Effects of Testosterone on the Spatial Ecology, Coloration, and Brain Regions in Western Fence Lizards, Sceloporus occidentalis
… MC, immature neurons, which express the protein doublecortin (DCX), migrate from the ventricles, through the inner plexiform layer and are integrated into the cell layer. Because DCX is only expressed in recently born, migrating neurons, it can be used to measure neurogenesis. In mammals and …
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Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus
The hippocampus (HPC) is important in spatial memory and navigation and also exhibits adult neurogenesis. In wild-living species, HPC volume and neurogenesis have been found to differ between the sexes and vary seasonally in tandem with spatial behaviours such as food-caching and mating. However, …
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Kidney tubulogenesis in human renal organoids: an investigation into the contribution of the microtubule-associated protein DCDC2
… course of MET, was completed. This highlighted doublecortin domain containing 2 (DCDC2) as a promising candidate. Based on a literature search DCDC2 is interesting because it acts as a MAP, it is highly upregulated in the epithelial portions of the human kidney and mutations in DCDC2 produce …
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Stereological Analysis of Oligodendrocyte Progenitor Cells In the Adult Mouse Brain
The main goal of this study was to further explore the hypothesis that experience-dependent neural network activity and neurotransmission can modulate adult OPC proliferation and differentiation. More specifically, we used stereology to establish whether extensive reference memory training and …
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ANALYSIS OF ADULT NEUROGENESIS AND HIPPOCAMPUS-DEPENDENT MEMORY IN MOUSE MODELS FOR AGING, ALZHEIMER’S DISEASE AND CRANIAL IRRADIATION-INDUCED NEUROINFLAMMATION
Aging in the brain is a complex process that affects every living being differently. Age-associated memory decline can be mild; however, memory can deteriorate quickly with in patients with mild cognitive impairment or a significant brain injury. Investigating therapeutics that support learning and …