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Showing 1 to 20 of 55 for “"Double-strand break repair"”.

  1. Double-Strand Break Repair Mechanisms in Human Embryonic Stem Cells

    Adams, Bret2015

    … most detrimental form of DNA damage is the DNA double-strand break (DSB), which is managed by cells through complex mechanisms, designated the DNA damage response. There are two major types of DSB repair; homologous recombination repair (HRR) and non-homologous end joining (NHEJ), both of which …

    vcu Repository record

  2. The Role of 53BP1 in DNA Double-Strand Break Repair

    Bothmer, Anne Helen

    <p>DNA double-strand breaks (DSBs) are dangerous insults to DNA integrity and can lead to genome instability if left unrepaired. However, the immune cell diversification reactions V(D)J recombination and Class Switch Recombination (CSR) require the formation of DSB intermediates, a process that is …

    rockefeller Repository record

  3. 53BP1 and double-strand break repair pathway choice in cancer

    Dev, Harveer SinghUniversity of Cambridge2019

    The cellular response to DNA double-strand breaks (DSB) is principally the result of two competing repair pathways. The Tumour Protein P53 Binding Protein 1 (TP53BP1) gene product plays a central role in DSB repair pathway choice, promoting non-homologous end-joining (NHEJ) and counteracting …

    cambridge Repository record

  4. DNA double-strand break repair studied by atomic force microscopy

    Zabolotnaya, EkaterinaUniversity of Cambridge2018

    DNA double-strand breaks (DSBs), where both strands of the DNA duplex are simultaneously fractured, are considered the most lethal type of DNA damage. The conserved Mre11-Rad50 DNA repair complex enables the catalytic activities of the Mre11 nuclease and the Rad50 ATPase to function together to …

    cambridge Repository record

  5. Double-Strand Break Repair Pathways In Dna Structure-Induced Genetic Instability

    Kha, Diem T2010

    … lead to genetic instability in the form of DNA double-strand breaks (DSBs) (1, 2). Our laboratory found that the stability of these non-B DNA structures was different in mammals versus Escherichia coli (E.coli) bacteria (1, 2). One explanation for the difference between these species may be a …

    uthsc Repository record

  6. Studies of site-specific DNA double strand break repair in plants

    Kuang, Xianyan2010

    … a site-specific DSB at the <i> Ds </i> locus for repair. Previous studies in maize and Arabidopsis showed that <i>Ac/Ds</i> excision can stimulate homologous recombination between tandem duplicated repeats and between ectopic homologies. In this study, we tested the efficacy of such <i>Ac/Ds</i> …

    iastate Repository record

  7. The role of linker histone variant in double strand break repair

    Arbon, Darren DUniversity of Birmingham2010

    … shown that linker histone variants inhibit the double strand break (DSB) repair pathway known as non-homologous end joining (NHEJ). NHEJ, in vivo, requires the KU complex, the DNA dependent protein kinase (DNA-PK) and the DNA ligase IV/XRCC4 (LX) complex. In vitro analysis has shown that several …

    birmingham Repository record

  8. Silencing, heterochromatin, and DNA double strand break repair in Saccharomyces cerevisiae

    Mills, Kevin D. (Kevin David), 1972-Massachusetts Institute of Technology1999

    Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.

    mit Repository record

  9. Single-molecule studies reveal mechanisms of human DNA double-strand break repair

    Myler, Logan RossThe University of Texas at Austin2018

    … complex pathways have evolved to recognize and repair these lesions. The most deleterious DNA damages are double-strand breaks (DSBs), and a single unrepaired DSB can lead to cell death. In human cells, there exist two canonical pathways of DSB repair: Non-Homologous End Joining (NHEJ) and …

    texas Repository record

  10. Cell-Cell Junction Signaling Regulating DNA Double-Strand Break Repair In Breast Cells

    ETHIRAJ, SINDUJA2015

    … epithelial cell malignancy in breast cancer. DNA double-strand break repair (DSBR) is one of the processes that get misregulated during breast cancer progression. In addition, radiation induced breaks such as those induced during radiation therapy to treat breast cancer patients are repaired by …

    vcu Repository record

  11. Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair

    Smith, Krissy Lynn

    <p>DNA double strand breaks (DSBs) are very deleterious events that occur in cells. Causes can include endogenous agents such as reactive oxygen and nitrogen species, exogenous agents such as ionizing radiation and ultraviolet light, or other sources such as processing of spontaneous DNA lesions or …

    south-carolina Repository record

  12. Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma

    Gil del Alcazar, Carlos Rodrigo2017

    … resistance to TMZ was due to the augmented repair of TMZ-induced DNA double strand breaks (DSBs). TMZ induces DNA replication-associated DSBs that are repaired primarily by the homologous recombination (HR) pathway. We found that cell lines from recurrent cultures exhibited faster resolution …

    utswmed Repository record

  13. DNA-PKcs/ Artemis Complex in DNA Double-Strand-Break Repair: Cryo-EM and Biochemical Studies

    Liang, ShikangUniversity of Cambridge2020

    … damage will thus have serious consequences. DNA double-strand breaks (DSB) are amongst the most lethal forms of DNA damage. One DSB can lead to catastrophic consequences including cancer and cell death. To fix it, there are two main mechanisms-- homologous recombination (HR) and non-homologous …

    cambridge Repository record

  14. Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae

    Omidi, KatayounCarleton University2017

    DNA Double Strand Break (DSB) is the most severe form of DNA lesion. Unrepaired DSBs and/or mutations in key DSB repair genes can lead to genomic instability, cancer or even cell death. DSBs can be repaired by two independent pathways; Homologous Recombination (HR) and Non-Homologous End Joining …

    carleton Repository record

  15. Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases

    Kruswick, Alex J.Massachusetts Institute of Technology2025

    DNA double strand breaks (DSBs) are considered to be the most lethal genotoxic lesion because they can result in chromosomal translocations or result in a major loss of genetic information if repaired incorrectly. To preserve genomic integrity, mammalian cells have evolved a set of complimentary …

    mit Repository record

  16. Study of mechanism of genetic death in Escherichia coli in response to A) dTTP starvation and B) combination of temperature sensitive defects in replication initiation and double strand break repair

    Rao, PrithaUniversity of Illinois at Urbana-Champaign2021

    … – dnaA in replication initiation and recBC, in double-strand-break repair. This lethality was discovered by Sharik Kahn, a Post-Doctoral researcher in this lab, and I continued to investigate this mysterious synthetic lethal combination. The first chapter presents a review of the phenomenon of …

    uiuc Repository record

  17. HMO2, a yeast HMGB protein that preferentially binds to DNA ends

    Ray, SreerupaBiological Sciences2022

    … remodeling complex INO80, which is involved in double strand break repair. I show here using DNA end-joining and exonuclease protection assays that HMO2 binds preferentially to DNA ends. While HMO2 binds DNA with both blunt and cohesive ends, the sequence of a single stranded overhang …

    lsu-thes Repository record

  18. Understanding angiosperm genome interactions and evolution: insights from sacred lotus (Nelumbo nucifera) and the carrot family (Apiaceae)

    Peery, Rhiannon MUniversity of Illinois at Urbana-Champaign2015

    … investigated included recombination and double-strand break repair, as evidenced by repeat DNA and the presence of transposable elements. The ‘China Antique’ plastome retains the ancestral gene synteny of Amborella and has no evidence of IGT. ‘China Antique’ has more smaller repeats in …

    uiuc Repository record

  19. Structural and biophysical analysis of Human DNA repair protein CtIP

    Morton, Christopher RobertUniversity of Cambridge2019

    … exogenous sources of DNA damage. The successful repair of DNA lesions is necessary for cellular survival and prevention of disease such as cancer. Therefore, complex molecular pathways have evolved to allow for accurate and timely DNA repair. It is now well-established that mammalian CtIP …

    cambridge Repository record

  20. Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer

    Lui, AllanUniversity of Cambridge2024

    … lethal with loss of OTUD5, a regulator of DNA double strand break repair and interferon signalling. Furthermore, ZNF703 overexpression favours error-free repair of CRISPR-Cas9-induced double strand breaks and confers increased dependency on homologous recombination. Interactomic and …

    cambridge Repository record

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