Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Double-Helix"”.
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Development of Three-Dimensional Super-Resolution Imaging Using a Double-Helix Point Spread Function
… of 3D-SMLM with novel techniques, including the double-helix point spread function (DHPSF). A bespoke microscope platform employing the DHPSF transformation was built, achieving ~10 nm lateral and ~20 nm axial localisation precision over a ~4 μm axial depth. Until recently, the DHPSF has been …
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Kinetics of Double Helix Formation With Homopolymers: Thermodynamic and Kinetic Studies of Dna-Ligand Interactions and Modified Dna
Made available in DSpace on 2014-12-10T23:01:36Z (GMT). No. of bitstreams: 1 7317585.pdf: 3628004 bytes, checksum: 84711905da6341d8329e58ba7d2e3308 (MD5) Previous issue date: 1973
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Industry dynamics within semiconductor value chain : IDM, foundry and fabless
… fabless companies. This analysis will utilize double helix [1] model with consideration of economics of scale, fixed cost and product life cycle. Furthermore, the cost and time-to-market factors involved in SoC (system-on-chip) and FPGA/PLD development will be explored. Based on the analysis, a …
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Model Calculations of Radiation Induced Damage in 1-Methylthymine:9-Methyladenine and in 1-Methyluracil:9-Ethyladenine.
… which are similar to the base pairs of the DNA double helix, are used in the study. Theoretical calculations are performed on the co-crystals 1-Methylthymine:9-Methyladenine and 1-Methyluracil:9-Ethyladenine and on the radicals observed in the experiment.The calculated aisotropic hyperfine …
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Using Synthetic Nanopores for Single -Molecule Analyses: Detecting SNPs, Trapping DNA Molecules, and the Prospects for Sequencing DNA
… nanopores, which are larger in diameter than the double helix of a DNA molecule but smaller in diameter than the DNA-protein complex. We relate the binding strength to the field threshold at which the complex dissociates. We also describe a method of measuring the transition from double-stranded …
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Okazaki Fragments
… <em>OF</em>’s guiding figure is the DNA double helix.</p>
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Advances in volumetric super-resolution microscopy and single-particle tracking
… 3D-SMLM techniques---such as the astigmatic and double-helix point spread functions (PSFs)---have been developed. These techniques encode the lateral and axial positions of single fluorophores into the PSF shape but at the cost of reduced spatial and temporal resolution. This limitation restricts …
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Reluctant Subjects: The Place of Gay Men in Canadian Media Discourse on HIV
… global health discourses are underpinned by the double helix of biopolitical and humanitarian imaginations, which I argue, require the production of morally worthy subjects for anchoring political and material responses to the pandemic. This is the case because biopolitical and humanitarian …
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Structural Studies of DNA Replication Machinery in Archaea
… of DNA replication is to separate the DNA double helix to generate a replication fork by exposing two single strands that serve as templates. Studies on the replication fork have identified large number of proteins involved in this process. The underlying mechanisms of DNA replication has …
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Supramolecular Assemblies: Dendrimers, Linear Arrays, and Polypseudorotaxanes
… (e.g., the tobacco mosaic virus and the DNA double helix) to the area of synthetic chemistry. As an example, the architecture of the double helix, perhaps the most well-known biological self-assembling structure, remarkably demonstrates the ability of biological systems to construct large …
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Investigation of Cdc45 function during helicase activation
… DNA replication initiation to unwind the DNA double helix and provide a ssDNA template for replicative DNA polymerases. Eukaryotic cells segregate helicase loading and activation events to ensure a single round of DNA replication per cell cycle. Upon entry into S-phase, Cdc45 and GINS …
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Synthesis of Metallic Nanowires Using Integrated DNA Molecules as Templates
The DNA double helix is inherently a nanoscale wire-like object, possessing a 2 nm diameter as well as a remarkable capability for molecular recognition and the interaction with other chemical compounds, thus making it an attractive material for biologically driven assembly of artificial …
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The combined AFM manipulation and fluorescence imaging of single DNA molecules
… by the termini or at specific sites along the double helix. These fixed and straightened strands could be overstretched laterally to ca. 1.6 times the original contour length. Chain rupture occurred at the tip position, but occasionally mid-strand rupture was also observed. An analysis of the …
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DNA Constraints for Rational Control of Macromolecular Conformation
The DNA double helix is stable and rigid, making it an ideal nanoscale construction element. Duplex DNA has been used as a static framework to organize DNA, proteins, or nanoparticles, and dynamic DNA nanomachines have been built. However, assemblies in which DNA controls the intramolecular states …
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Spontaneity to serendipity: from an enediyne core biosynthetic hypothesis to the hexadehydro-Diels-Alder reaction
… yield a diradical capable of scission of the DNA double helix. While the biological mechanism of action is well established, almost nothing is known about the biosynthesis of the enediyne core. Specifically, researchers have been unable to identify a cyclase enzyme capable of ring-closing acyclic …
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
Genomic DNA is organized around the double-stranded of B-form DNA, which is both durable and flexible enough to store and pass on genetic information. Once freed from the associations of an extended complimentary sequence, single stranded DNA and RNA can adopt a vast array of stable secondary …
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
Genomic DNA is organized around the double-stranded of B-form DNA, which is both durable and flexible enough to store and pass on genetic information. Once freed from the associations of an extended complimentary sequence, single stranded DNA and RNA can adopt a vast array of stable secondary …
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Development, Characterization, and Fundamental Studies on Molecular Ionic Composites and PBDT Hydrogels
… (PBDT), which forms a double helix, combined with imidazolium-based ionic liquids (ILs). The IL comprises 75-97 wt% of the final solid, even though the Young's modulus can reach ~ 2 GPa at 80 wt% IL. We propose that these properties are driven by a biphasic internal …
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The Effect of Spermidine on the Rate of Sex-Linked Recessive Lethals Caused by X-Ray in Drosophila Melanogaster
… heat denaturation of DNA by binding to the DNA double helix. The agent has also decreased the development of resistance of bacteria to a particular antibiotic. The major objective of this study was to determine if treatment to "Drosophila" with a given concentration of spermidine prior to X-ray …
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Facilitating Non-Covalent Interactions: 'Nanoglue' for DNA-CNT Nanohybrid Complexes
… to the possibility of intercalation into the DNA double-helix. This alternate binding mode was investigated. The second generation dendrimer exhibited slightly reduced binding ability relative to its cationic charge, in opposition to the increase in binding strength that would be expected due to …
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