Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Dose-Exposure-Response"”.
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Evaluation of Dose-Exposure-Response Relationships of Miltefosine and Discovery of Multicomponent Crystal Forms of Artesunate
… the drug is associated with differences in exposure patterns and cure rates among different population groups e.g. ethnicity and age (i.e., children v adults) in clinical trials. Artesunate (ATS), a BCS class II drug widely used for anti-malaria therapy, exhibits not only poor solubility but …
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Model-Based Dose-Exposure-Response Assessment for Lead and Backup Spectinamide in a Mouse Model of Tuberculosis
… in various in vitro and in vivo assessments. The dose-ranging and dose fractionation studies were designed to characterize the dose-exposure-response relationship for lead and backup spectinamide in a mouse model of Mycobacterium tuberculosis infection. In this current study, we used 26 and 23 …
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Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation in the Development of Spectinamides, a Novel Class of Anti-Tuberculosis Agents
… for spectinamides.</p> <p>To characterize the dose-exposure-response of Lee 1810, a dose-fractionation study was performed in BALB/c mice infected with a low dose aerosol of <em>(Mtb)</em>. Dosing with different dosing regimens was continued for 4 weeks with two blood samples obtained from each …