Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"Dose levels"”.
-
An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
… to different agents, and 3) higher achievable dose intensity by exploiting non-overlapping toxicities to the host. Even if the toxicity profile of each agent of a given combination is known, the toxicity profile of the agents used in combination must be established. Thus, caution is required …
-
Effects of Norharmane and Nicotine on the Conditioned Place Preference of Mice
… a weakly reinforcing substance at low and high dose levels. Due to this, other tobacco constituents, such as the monoamine oxidase inhibitor norharmane which is found in tobacco leaf and smoke, may be responsible for tobacco addiction by potentiating the rewarding properties of nicotine. Several …
-
Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure to 1,2:5,6 Dibenzanthracene in B6C3F1 Mice
… mice were administered DBA daily in corn oil at dose levels of 158, 500, 1580, and 5000 µglkg S.C. for 28 days. Immunosuppression was not observed at levels less than 5000 µgkg in the following immune parameters: NK cell activity, anti-CD3 antibody-mediated proliferation and mixed-leukocyte …
-
Dual task performance and antihistimine use
… that there are behavioral effects at therapeutic dose levels. Therefore, the objective of this research was to determine whether a complex cognitive and motor task (memory search and tracking combination) showed a performance deterioration under the influence of two antihistamines (benadry| and …
-
Comprehensive Calculation-Based Imrt Qa Using R&V Data, Treatment Records, and A Second Treatment Planning System
… detect uncertainties introduced by the initial dose calculation, the data transfer through the Record-and-Verify (R&V) system, and various aspects of the physical delivery.<strong> </strong></p> <p><strong>Methods: </strong>We recomputed the treatment plans in the patient geometry for 48 cases …
-
Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics
… been tested at various combinations of dose level, dosing frequency, and routes of administration in mouse models of Mtb infection and in healthy animals. Characterizing the disposition of a compound in the tissues of interest is important in understanding the pharmacology of novel …
-
Heavy-ion damage in copper, nickel and dilute nickel alloys
… element, irradiation temperature and ion dose on the probability of collapse of a displacement cascade, Cu, Ni, and dilute Ni alloys (Ni-Si and Ni-Al) have been irradiated with 50 and 100 keV heavy-ions (Kr$\sp+$ and Ni$\sp+$) at both 30 and 300K, and to doses ranging from …
-
FBS0701: un nuovo chelante orale nel trattamento del paziente con sovraccarico trasfusionale di ferro
… study was to assess the safety, tolerability and dose response of FBS0701, a novel oral iron chelator. Design and Methods This phase 2 study to assess the safety, tolerability, dose response of FBS0701, was conducted in 14 adult patients with iron overload consequent to transfusions.Two once-daily …
-
Postradiation sarcomas
… [2] to establish as accurately as possible dose levels at which the postradiation tumors have developed; and [3] to briefly describe possible risk factors such as a genetic predisposition to the development of malignancy, repeated courses of radiotherapy, surgery as part of the treatment of …
-
Reducing radiation dose for a linear slot scanning digital X-ray machine using a filtration technique
… digital X-ray system to reduce radiation dose to paediatric patients whilst preserving diagnostic image quality. The Statscan is an FDA approved, commercially available digital X-ray system commonly used for trauma and emergency patients. The Statscan provides significantly lower radiation …
-
Optimization of a High-Energy X-Ray Inline Phase Sensitive Imaging System for Diagnosis of Breast Cancer
… while reducing the risks of harmful radiation dose delivered to the patient. As a result, numerous advancements have been made over the last two decades which include the introduction of digital mammography (DM) and digital breast tomosynthesis (DBT). Numerous clinical trials have demonstrated …
-
Advanced characterization of the early-stage evolution of microstructures and mechanical properties in neutron-irradiated commercial steels
… Three temperature ranges and four neutron dose levels were investigated in this study. Utilizing transmission electron microscopy (TEM), atom probe tomography (APT) and energy dispersive X-ray spectroscopy (EDS), the nucleation, growth and stability of dislocation loops, G phase, α’ phase, …
-
A Novel Trajectory Vector Approach for Characterizing Dynamic Changes in the Performance-Load Representation of Cardiac State
… cardiac states and distinguish intervention dose levels, with minimal influences from the level of Impella support, is realized. With the ability to monitor shifts in performance-load relationship, a reflection of the heart’s current inotropic state, our technique can be applied in the clinic …
-
An Adaptive Dose Finding Design (DOSEFIND) Using A Nonlinear Dose Response Model
… trials are the first time that an NCE is dosed in human subjects, the designs used in these trials are unique and geared toward patient safety. We develop a method for obtaining the desired response using an adaptive non-linear approach. This method is applicable for studies in which MTD, …
-
Anti-diabetic properties of GUH
… were then treated with GUH at 5 different dose levels, metformin or rosiglitazone for twelve weeks. Food intake, liquid intake, weights, blood glucose, and insulin were monitored throughout the treatment period. An intravenous glucose tolerance test (IVGTT) was performed on representative …
-
Silicon Carbide - Nanostructured Ferritic Alloy Composites for Nuclear Applications
… of ion irradiation was recorded after particular dose levels (0-10 dpa) at 300oC and 450oC temperatures. NFA sample showed heavy dislocation damage at both 300oC and 450oC increasing gradually with dose levels (0-10 dpa). Cr3C2@SiC-NFA showed similar behavior as NFA at 300oC. However, at 450oC, …
-
IRON OVERLOAD AND BIRTH DEFECTS
Large, intravenous doses of iron-dextran are teratogenic in a number of laboratory species (M Phil). To elucidate the mechanism, studies were performed in rats and rabbits to identify possible maternal, placental and foetal sites of action. Maternal toxicity, manifested by bodyweight depression, …
-
Assessment of Collimator Jaw Optimization In Reducing Normal Tissue Irradiation With Intensity Modulated Radiation Therapy
… To evaluate normal tissue dose reduction in step-and-shoot intensity-modulated radiation therapy (IMRT) on the Varian 2100 platform by tracking the multileaf collimator (MLC) apertures with the accelerator jaws.</p> <p><strong>Methods: </strong>Clinical radiation treatment …
-
Estimate of radiation release from MIT reactor with low enriched uranium (LEU) core during maximum hypothetical accident
… the maximum hypothetical accident (MHA) dose implications for the two types of fuel. In this work, the dose levels at the site exclusion area boundary were calculated for the MITR MHA using both the HEU and LEU models of the MITR core. The core inventories from the reactor were calculated …
Page 1 of 3