Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Dose Response Modeling"”.
-
Efficient Design Of Biological Experiments For Dose-Response Modeling In Nanomaterial Toxicology Studies
… proposed design method adopts suitable nonlinear dose response curve and non-constant variance model in experimental modeling, which more adequately represents the desirable properties of bioassay-experiment. A multiple objective genetic algorithm were used to select best set of non-dominated …
-
Novel Approaches to Exposure Assessment and Dose Response to Contaminants in Drinking Water and Food
… novel methods for exposure assessments and dose responses to contaminants in drinking water and foods. Factors that greatly impact contaminant exposures and human dose response include: population susceptibility (i.e., healthy adults or children), different routes of exposures (i.e., …
-
Nonparametric Statistical Approaches for Benchmark Dose Estimation in Quantitative Risk Assessment
… of quantitative risk assessment involves dose-response modeling. Therein, an appropriate statistical model that approximately quantifies the relationship between exposure level (dose) and response (adverse endpoint) is fit to experimental data. The objective of this dissertation is to …
-
A Bayesian Approach to Dose-Response Assessment and Drug-Drug Interaction Analysis: Application to In Vitro Studies
… and minimizing or delaying drug resistance. Dose-response assessment and drug-drug interaction analysis play an important part in the drug discovery process, however analysis are often poorly done. This dissertation is an effort to notably improve dose-response assessment and drug-drug …
-
Infrastructure Development For Personalized Risk Prediction to Reduce Cardiovascular Disease In Childhood Cancer Survivors
… and this risk rises with higher mean heart doses and increased RT exposure to larger cardiac volumes. Since, the heart is a heterogeneous organ made up of several distinct substructures, RT dose received by the entire heart does not accurately represent the doses to the various cardiac …