Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Dosage regimen"”.
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Application of population pharmacokinetic-pharmacodynamic modelling evaluate and optimise aminoglycoside therapy in patients with cystic fibrosis
… of therapy and advise on current and future dosage regimens. The focus of this thesis was to use population pharmacokinetic methodologies to examine how aminoglycoside pharmacokinetic parameters change over time in this group of patients and to develop and evaluate dosing regimens and data …
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The efficacy and safety of artesunate suppositories in combination with other antimalarials in the treatment of severe malaria in Sudan.
… of this study revealed the efficacy of a novel dosage regimen of artesunate suppositories, and the comparative efficacy and safety of three combined antimalarials in preventing recrudescence. The modified HPLC-UV method used in the present study showed appropriate validation and provided …
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An Examination of the Safety and Efficacy of Aripo-Zika as a Zika Virus Vaccine Candidate
… of maternal antibodies, (ii) the optimal dosage regimen, (iii) anti-vector immunity to the ARPV backbone, and (iv) the effects of boosters on vaccine efficacy. We also evaluated AZ safety via a co-infection study. Our results show a near linear relationship between increased dose and …
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Paediatric Dexmedetomidine Pharmacology
… dexmedetomidine and blood pressure elucidated. Dosage regimens to achieve target concentrations are suggested. Dexmedetomidine pharmacokinetic parameters and their variability (between-subject variability, CV%) for children after cardiac surgery were estimated using non-linear mixed effects …
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Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
… to reverse the fibrosis. After the end of dosage regimen, the rats were euthanized and the analysis was performed for the liver fibrosis molecular markers. We found that the neutravidin PCBP2 siRNA nanocomplex successfully reversed the liver fibrosis by significantly reducing the molecular …
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Design of novel drug delivery system and optimal dosage regimens
… a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion of theophylline, could be obtained once information on the pharmacokinetics became available. The method was based on a two-compartment model of the human body. A module was …
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Challenges in the Pharmacokinetics of Therapeutic Proteins
… body weight should be considered during dosage regimen design, especially for pediatric patients who show a highly dynamic change in body size at early age.</p> <p>In summary, the findings in this dissertation have pointed out the weakness of the classical bioavailability estimation for …
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Development of novel antibody-targeted nanoparticle strategies for treatment of pancreatic cancer
… cancer treatment as part of the FOLFIRINOX regimen. <br/><br/>To improve antibody conjugation a novel N-hydroxysuccinamide endcapped polymer was employed to circumvent the need for in situ EDC functionalisation of carboxyl groups. This resulted in improved AMG 655 conjugation efficiency …
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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences
… in patients with SCCHN at the currently approved dosage regimen, and that the cetuximab PK parameters remained constant during prolonged therapy.</p> <p> Nonlinear eliminaton is a common characteristic of the PK of therapeutic mAbs. Accordingly, PK models with nonlinear elimination are commonly …
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Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation in the Development of Spectinamides, a Novel Class of Anti-Tuberculosis Agents
… critical role in identifying the optimum dosing regimen for new treatments. In this dissertation, I hypothesized that the application of translational PK/PD modeling and simulation techniques would facilitate rational dosage regimen design for spectinamides.</p> <p>To characterize the …