Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Dorsomedial Hypothalamus"”.
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Restriction of Food Intake by Dorsomedial Hypothalamus
… profile leptin responsive neurons in the hypothalamus and brain stem. In addition to identifying several known leptin responsive populations, we found that neurons in Dorsomedial Hypothalamus (DMH) expressing GSBS are activated in ob/ob mice and suppressed by leptin treatment. Because ob …
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Microdialysis in the study of GABA and other putative amino acid neurotransmitters in the dorsomedial hypothalamus
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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MOLECULAR MECHANISMS OF APPETITE AND ENERGY BALANCE
… hyperphagia. Deletion of ELKS in the dorsomedial hypothalamus, but not in other key feeding nuclei, also caused obesity and hyperphagia. Nkx2.1 neurons in the DMH are glutamatergic, co-express orexin-A, and project to brain reward centers. Synaptic transmission dynamics is crucial to …
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Induction of Interleukin-1(beta) Converting Enzyme in the Brain and Its Role in Anorexia Induced by Centrally Administered Lipopolysaccharide
… areas examined, but the hippocampus and the dorsomedial hypothalamus comprised a dense population of cells expressing ICE mRNA. These results provide further support for the role of IL-1beta in LPS-induced anorexia and indicate ICE may be a viable pharmacological target for inhibiting this …
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Mechanisms Involved in Human Thermogenesis
… homeostasis. GPR10-mediated signalling in the dorsomedial hypothalamus is necessary for the thermogenic effects of leptin. We have undertaken a detailed functional study of the mutations found from the whole exome and targeted resequencing of patients with severe early onset obesity, recruited …
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CHARACTERIZATION OF TRANSMEMBRANE PROTEIN 35 EXPRESSION: CONSIDERATIONS OF SEX AND OVARIAN HORMONES
… expression of TMEM35 in both the ventromedial hypothalamus (VMH) and the limbic circuit of the mouse brain. Due to the known functions of these two regions, this pattern of expression indicates possible roles of this neuropeptide in social behavior and reward processing. Interestingly, TMEM35 …
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Noninvasive Neuromodulation via Ultrasonic Activation of Endogenous and Exogenous Ion Channels
… by modulating the preoptic area (POA) of the hypothalamus. The depth and duration of this state can be precisely controlled by ultrasound parameters. This behavior change was found to be directly related to the ultrasound-induced neuronal activation in POA regions. These neurons act on the …
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Metabolic signalling and neuroendocrine stress responses in pregnancy
… lateral hypothalamic area (LPIA), ventromedial hypothalamus (VMH) and dorsomedial hypothalamus (DMH). Supraoptic and magnocellular PVN oxytocin responses to centrally administered NPY were reduced during late pregnancy. Endogenous opioids are involved in the attenuation of HPA axis responses to …
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Neurochemical and functional characterisation of the Melanin-concentrating hormone system in the rat brain
… immunohistochemistry within the rat hypothalamus. Of special interest is the neuroanatomical identification of other hypothalamic neuropeptides that are co-distributed with MCHR-1. A second part of this study deals with the examination of neuronal activation patterns after …
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A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… Specifically in the central amygdala (CEA), dorsomedial hypothalamus (DMH), ventromedial hypothalamus (VMH) and the nucleus accumbens (Acb). Excessive consumption palatable sucrose sucrose was was ameliorated in mutants by intraperitoneal administration of oxytocin (OT), a satiety promoting …